Key takeaways
Melatonin and Ambien (zolpidem) are both used to help with insomnia (trouble sleeping). But melatonin is a supplement that’s available over the counter, and Ambien is prescription only. Melatonin may help with sleep issues like jet lag and short-term insomnia, and it has fewer side effects than Ambien. Ambien is a controlled substance that works quickly to help you fall asleep, but comes with more serious risks (such as sleepwalking) and potential for dependence and misuse. Melatonin supplements aren’t regulated by the FDA so it’s important to know how to choose a supplement that’s high-quality.
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