Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Advair vs. Trelegy Ellipta

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Fluticasone/salmeterol (Advair) and fluticasone/umeclidinium/vilanterol (Trelegy Ellipta) are both inhaled medications used for the maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD). They both contain fluticasone, an inhaled corticosteroid, which helps reduce inflammation in the lungs. However, they differ in their composition and usage. Advair combines fluticasone with salmeterol, a long-acting beta agonist (LABA), while Trelegy Ellipta includes fluticasone, umeclidinium (a long-acting muscarinic antagonist or LAMA), and vilanterol (another LABA). Advair is available in both Diskus and HFA forms and is typically taken as 1 to 2 puffs twice daily, whereas Trelegy Ellipta is taken as one inhalation once daily. Advair is available in generic form, but Trelegy Ellipta is only available as a brand-name medication. Common side effects of Advair include upper respiratory infections and sore throat, while Trelegy Ellipta may cause headaches and back pain. Both medications require you to rinse your mouth after use to prevent fungal infections, and they should not be used for sudden breathing problems.

  • Advair (fluticasone / salmeterol)
    Trelegy ellipta
  • Advair (fluticasone / salmeterol)
    Trelegy ellipta

  • Summary of Advair vs. Trelegy Ellipta

    Summary for ICS / LABA combo
    Prescription only

    Advair is a combination inhaler that contains fluticasone (an inhaled corticosteroid) and salmeterol (a long-acting beta agonist, or LABA). Advair Diskus is used for maintenance treatment of chronic obstructive pulmonary disease (COPD) and asthma in adults and children, where as Advair HFA is for asthma only. Advair (fluticasone / salmeterol) is inhaled through the mouth, typically 1 to 2 puffs twice daily. Some common side effects of this medication include upper respiratory tract infection, sore throat, and headache.

    Summary for ICS / LAMA / LABA
    Prescription only

    Trelegy Ellipta is a combination maintenance inhaler used to treat adults with chronic obstructive pulmonary disease (COPD) and asthma. It contains three active ingredients: fluticasone (a corticosteroid), umeclidinium (a long-acting muscarinic antagonist), and vilanterol (a long-acting beta agonist). Together, these help reduce airway inflammation, relax airway muscles, and help keep your airways open. The typical dose is one puff inhaled through the mouth once a day. Common side effects include headache, cough, and back pain.

  • Indications of Advair vs. Trelegy Ellipta

    Indications for
    •Maintenance treatment of asthma
    •Maintenance treatment of COPD - Advair Diskus 250/50 only
    Indications for
    •Maintenance treatment of asthma
    •Maintenance treatment of chronic obstructive pulmonary disease (COPD)

  • Pros and Cons of Advair vs. Trelegy Ellipta

    Pros and Const for ICS / LABA combo
    Pros
    •Works well to lower the risk of asthma or COPD symptoms
    •Combines two medications into a single inhaler for convenience
    •Available as two different types of inhalers (Advair Diskus and Advair HFA)
    Cons
    •Can cause fungal infections (thrush) in your mouth and throat
    •Advair Diskus contains lactose, so it might not be safe for people with severe milk protein allergies
    •Doesn't replace your rescue inhaler
    Pros and Const for ICS / LAMA / LABA
    Pros
    •Only need to inhale one puff once a day
    •Combination of three medications within a single inhaler
    •Approved for both COPD and asthma
    Cons
    •Common side effects include headache and cough
    •Can't use if severely allergic to milk proteins because it contains lactose
    •Need to rinse your mouth after each dose to prevent oral thrush

  • Common Side Effects of Advair vs. Trelegy Ellipta

    Common Side Effects for

    Advair Diskus:

    •Upper respiratory infection (up to 27%)
    •Sore throat (up to 13%)
    •Headache (up to 13%)
    •Bronchitis (up to 8%)
    •Cough (up to 6%)
    •Nausea and vomiting (up to 6%)
    •Hoarseness (up to 5%)

    Advair HFA:

    •Upper respiratory infection (up to 24%)
    •Headache (up to 21%)
    •Throat irritation (up to 9%)
    •Muscle and bone pain (up to 7%)
    •Nausea and vomiting (up to 5%)
    Common Side Effects for

    COPD:

    •Headache (4%)
    •Back pain (4%)
    •Changes in taste (2%)
    •Diarrhea (2%)

    Asthma:

    •Common cold symptoms (up to 17%)
    •Headache (up to 9%)
    •Upper respiratory tract infection (up to 7%)
    •Bronchitis (up to 5%)
    •Sinus infection (up to 3%)
    •Back pain (up to 3%)

  • Warnings of Advair vs. Trelegy Ellipta

    Common Side Effects for
    •Not for use in asthma attack or for worsening breathing
    •Fungal infection in the mouth
    •Narrowing of your airways (bronchospasm)
    •Higher risk of infections
    •Altered stress hormone levels
    •Delayed growth in children
    •Eye and vision problems
    •Heart problems
    •Low potassium levels in the blood
    •Allergic reactions
    Common Side Effects for
    •Worsening symptoms or sudden flare-ups
    •Overdose
    •Oral thrush
    •Pneumonia
    •Risk of infection
    •Changes in stress hormone levels
    •Sudden narrowing of the airways
    •Serious allergic reaction
    •Heart problems
    •Weaker bones
    •Eye problems
    •Trouble urinating
    •Worsening of certain health conditions
    •Low potassium and high blood sugar

  • Prices with our coupons for Advair vs. Trelegy Ellipta

    Learn more about Advair
    Learn more about Trelegy ellipta

Compare other Asthma and COPD drugs

Advair vs AlbuterolAdvair vs PulmicortAdvair vs Trelegy ElliptaAirduo vs AdvairAtrovent vs AdvairBreo Ellipta vs AdvairBreztri Aerosphere vs AdvairDulera vs AdvairFlovent vs AdvairQvar vs AdvairSingulair vs AdvairSpiriva vs AdvairSymbicort vs AdvairTheophylline vs AdvairWixela Inhub vs AdvairXopenex vs AdvairAlvesco vs FloventDulera vs FloventFlovent vs AlbuterolFlovent vs AllegraFlovent vs Arnuity ElliptaFlovent vs AsmanexFlovent vs FlonaseFlovent vs FlunisolideFlovent vs NasonexFlovent vs PulmicortFlovent vs Pulmicort FlexhalerFlovent vs QnaslFlovent vs SymbicortQvar vs Flovent
View More

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.