Sulfonylurea / biguanide combinations are used to treat Type 2 diabetes. They work by combining two types of diabetes treatments: a sulfonylurea and a biguanide. Sulfonylureas help your pancreas produce more insulin. Biguanides decrease the amount of glucose (sugar) your liver makes and improve your body's response to its natural insulin. These combinations are available as oral tablets. Examples include glyburide / metformin and glipizide / metformin. You can discuss with your healthcare team which option might be right for you.