Local anesthetic / nonsteroidal anti-inflammatory drug (NSAID) combinations are used to treat post-surgical pain, osteoarthritis, and acute musculoskeletal pain. These medications work by combining the numbing effect of a local anesthetic with the anti-inflammatory properties of an NSAID, which helps to reduce pain and swelling. These medications come in different forms, including topical gels and injectable solutions. Examples include diclofenac / lidocaine (Diclona Gel), diclofenac / menthol / methyl salicylate (Fenovar, Varophen), and bupivacaine / meloxicam (Zynrelef). You can discuss with your healthcare team which option might be right for you.