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Diclona

diclofenac / lidocaine
Used for Pain
Used for Pain

Diclona Gel (diclofenac / lidocaine) is applied to the skin to relieve aches and pains temporarily from arthritis, sore muscles, and joints. It's a combination of two topical medications which can be found over-the-counter (OTC) individually (lidocaine and diclofenac). This combination is only available as a brand-name prescription medication, so it can be expensive.

Last reviewed on September 1, 2022
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What is Diclona Gel (diclofenac / lidocaine)?

What is Diclona Gel (diclofenac / lidocaine) used for?

Pain, discomfort, and soreness caused by:

  • Arthritis

  • Backache

  • Cramps

  • Neckache

  • Sprains

  • Strains

How Diclona Gel (diclofenac / lidocaine) works

Diclona Gel (diclofenac / lidocaine) is a combination of two different topical medications. Diclofenac is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking proteins called cyclooxygenase 1 and 2 (COX-1 and COX-2) enzymes from making chemicals called prostaglandins. Prostaglandins play many roles in your body, including causing pain and swelling where you get injured. By blocking your body from making prostaglandins, this medication eases joint pain and swelling.

Diclona Gel (diclofenac / lidocaine) also contains lidocaine, which eases pain by numbing the nerves and making them less sensitive to pain or irritation. Lidocaine is a local anesthetic, meaning it only lowers pain in the area of skin closely around or directly in contact with the medication.

Are you looking for information on diclofenac topical products, lidocaine topical products, or dicloxacillin (Dynapen) instead?

Drug Facts

Common BrandsDiclona Gel
Drug ClassLocal anesthetic / NSAID
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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Avg retail price
$1079.68(save 30.44%)
GoodRx discount
$750.98
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What are the side effects of Diclona Gel (diclofenac / lidocaine)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Application site reactions:
  • Burning sensation
  • Blisters
  • Bruising
  • Discoloration or white/light spots on skin
  • Skin irritation
  • Swelling
  • Itching
  • Small raised bumps
  • Abnormal sensation on skin

Other Side Effects

  • Weakness
  • Dizziness
  • Headache
  • Metallic taste in your mouth
  • Changes in your sensations
  • Nausea
  • Nervousness
  • Blurred vision
  • Flushing

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Heart attack: dizziness, tiredness, cold sweat, trouble breathing, chest pain or tightness, anxiety
  • Stroke: tiredness, lightheadedness, blurred vision, difficulty speaking, difficulty walking, weakness on one side of the body
  • Serious allergic or skin reaction: fever, body aches, cough, peeling skin, rash, swelling of the face, painful blisters all over your body
  • Blood problems (methemoglobinemia): Seizures, loss of consciousness, fast heart beat, trouble breathing, feeling dizzy or faint, feeling tired, skin color turning blue or pale
  • Too much lidocaine in your body: Drowsiness, confusion, slow heartbeat, trouble breathing, difficulty controlling muscle movements

Source: DailyMed

pros-and-cons

Pros and cons of Diclona Gel (diclofenac / lidocaine)

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Pros

Can be applied directly to the painful area

Combines two different topical pain medications

Clothing can be worn over where you applied the medication

Can be used up to 4 times a day

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Cons

Can cause eye irritation if it makes contact with the eyes

Should avoid sun exposure during treatment

Might not be safe for people with serious liver problems

Can cause a skin reaction where applied

pharmacist-tips

Pharmacist tips for Diclona Gel (diclofenac / lidocaine)

pharmacist
  • Clean and dry the affected area before applying Diclona Gel (diclofenac / lidocaine). Clothing can be worn over the area of application.

    • If irritation or a burning sensation occurs when applying Diclona Gel (diclofenac / lidocaine), wash the medication off and don't reapply it until the irritation goes away.

      • Ask your provider before using Diclona Gel (diclofenac / lidocaine) with other topical pain relievers or local anesthetics. It's possible to absorb too much medication, giving you a higher risk of side effects when Diclona Gel (diclofenac / lidocaine) is used with other topical medications.

        • Diclona Gel (diclofenac / lidocaine) is flammable (meaning it can easily catch fire). Keep this medication away from open flames.

          • Avoid using heating pad or electric blankets on an area treated with Diclona Gel (diclofenac / lidocaine). This can cause you to absorb too much of the medication leading to a higher risk of side effects.

            • Wash hands well after applying Diclona Gel (diclofenac / lidocaine) to avoid spreading it to other areas of the body or getting it in your eyes where it can cause irritation.

              faqs

              Frequently asked questions about Diclona Gel (diclofenac / lidocaine)

              Where can I apply Diclona Gel (diclofenac / lidocaine)?
              You should only apply Diclona Gel (diclofenac / lidocaine) to skin that's not broken or damaged. Applying this medication to broken or inflamed skin can cause you to absorb more of the medication and raise your chance of experiencing side effects, such as skin irritations. You should also avoid getting Diclona Gel (diclofenac / lidocaine) in your eyes as this can cause serious eye irritation.
              Does Diclona Gel (diclofenac / lidocaine) make you more sensitive to the sun?
              You're recommended to avoid the sun when using Diclona Gel (diclofenac / lidocaine). Though rare, the diclofenac in this medication can make your skin more sensitive to the sun. This can result in redness, irritation, or rash after sun exposure.
              Can I take ibuprofen (Advil) tablets along with Diclona Gel (diclofenac / lidocaine)?
              You're not recommended to use ibuprofen (Advil) tablets with Diclona Gel (diclofenac / lidocaine), unless your provider instructs you to do so. Both Ibuprofen (Advil) and the diclofenac in Diclona Gel (diclofenac / lidocaine) are nonsteroidal anti-inflammatory drugs (NSAIDs). Using these medications together puts you at higher risk for side effects, such as blood clots and swelling in the hands and feet. If Diclona Gel (diclofenac / lidocaine) alone isn't enough to treat your pain, discuss with your provider about other options for you. Please be aware that NSAIDs are found in many common over-the-counter and prescription pain medications. They sometimes appear in combination with other medications to treat different conditions, such as the common cold or trouble sleeping. Talk with your healthcare provider or pharmacist if you're not sure whether you're already taking an NSAID.
              Does Diclona Gel (diclofenac / lidocaine) interact with any other medications?
              Yes, Diclona Gel (diclofenac / lidocaine) could potentially interact with certain medications. Ask your provider before using Diclona Gel (diclofenac / lidocaine) if you're taking medications to correct a heart rhythm problem. Certain heart rhythm medications, like mexiletine, can raise your chance of having serious side effects from Diclona Gel (diclofenac / lidocaine). Diclona Gel (diclofenac / lidocaine) also shouldn't be used with other local anesthetics, like benzocaine. Using multiple local anesthetics can raise your risk of serious side effects like methemoglobinemia, a problem in which your blood can't carry enough oxygen to the cells in your body.
              Can I use Diclona Gel (diclofenac / lidocaine) if I have a liver problem?
              Diclona Gel (diclofenac / lidocaine) might not be safe for people with serious liver problems. This is because the liver is responsible for breaking down lidocaine in the body. For this reason, lidocaine levels might get too high if this medication is used by people with liver problems. This can result in a higher risk for side effects from Diclona Gel (diclofenac / lidocaine).
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              What are the risks and warnings for Diclona Gel (diclofenac / lidocaine)?

              Diclona Gel (diclofenac / lidocaine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Blood problems (methemoglobinemia)

              • Risk factors: History of methemoglobinemia | History of low glucose-6-phosphate dehydrogenase (G6PD) | Heart or lung problems | Age 6 months or younger | Exposure to other oxidizing agents, such as chlorine and hydrogen peroxide

                Diclona Gel (diclofenac / lidocaine) can cause a condition known as methemoglobinemia where your blood can't get enough oxygen to your body. This is linked to the lidocaine in this product and it can be life-threatening. Your risk is higher if you have low G6PD, a condition passed down from parent to child, where your red blood cells tend to burst or break apart. Be careful using Diclona Gel (diclofenac / lidocaine) if you're around oxidizing chemicals, such as chlorine and hydrogen peroxide. These chemicals might be present in common household products like cleaning supplies and hair dye. Methemoglobinemia can occur immediately or within hours of using Diclona Gel (diclofenac / lidocaine). Earliest signs include headache, tiredness, and your skin turning blue. Get medical help right away to avoid more serious and life-threatening side effects like seizures, loss of consciousness, and heart rhythm problems (fast heart beat, dizziness, shortness of breath).

                risk-warning

                Heart attack and stroke

                • *Risk factors: Using Diclona Gel (diclofenac / lidocaine) for a long period of time *

                  Nonsteroidal anti-inflammatory drugs (NSAIDs), like the diclofenac in Diclona Gel (diclofenac / lidocaine), can raise your risk of having blood clots, heart attacks, or strokes. This can happen early during treatment, but people using NSAIDs for a long time have a higher risk of this happening. That’s why it’s important to use the lowest possible dose for the shortest possible time. If you have heart problems, talk to your healthcare provider before starting this medication. Call 911 or get immediate medical help if you experience chest pain, trouble breathing, weakness on one side of your body, or trouble speaking or walking.

                  risk-warning

                  Serious skin reactions

                  NSAIDs, such as diclofenac, might cause sudden, very serious, and sometimes life-threatening allergic and skin reactions. Symptoms include fever, body aches, rash, peeling skin, painful blisters all over your body, and swelling of the face. Stop Diclona Gel (diclofenac / lidocaine) and get help right away if you experience these symptoms.

                  risk-warning

                  Heart failure and swelling of your arms and legs

                  • Risk factors: Heart failure

                    The diclofenac in Diclona Gel (diclofenac / lidocaine) can cause your body to hold onto more water. This can lead to new or worsening existing heart failure and swelling of your arms and legs. Let your provider know if you notice any changes in your blood pressure or experience symptoms, such as trouble breathing, tiredness, swelling in your body, or sudden weight gain.

                    risk-warning

                    Harm to unborn babies

                    • Risk factors: Currently in second or third trimester of pregnancy

                      Don't use Diclona Gel (diclofenac / lidocaine) or other NSAIDs starting around the third trimester of pregnancy because doing so can lead to serious heart or kidney problems in your unborn baby. If you want to use Diclona Gel (diclofenac / lidocaine) in your second trimester, talk with your provider first to see if the benefit of pain relief is greater than the risk of kidney problems in your unborn baby. If you do need to use Diclona Gel (diclofenac / lidocaine) during your second trimester, make sure to use the lowest dose for the shortest period of time. If you're pregnant or thinking of getting pregnant, talk to your provider about the risks and benefits of using Diclona Gel (diclofenac / lidocaine).

                      dosage

                      Diclona Gel (diclofenac / lidocaine) dosage forms

                      The average cost for 1 tube of 99g of 4.5%/1% of Diclona Gel (diclofenac / lidocaine) is $1002.54 with a free GoodRx coupon. This is 7.14% off the average retail price of $1079.68.
                      carton
                      Carton
                      DosageQuantityPrice as low asPrice per unit
                      15 patches of 4.5%/1.25%1 carton$750.98$750.98
                      tube of gel
                      Tube of gel
                      DosageQuantityPrice as low asPrice per unit
                      99g of 4.5%/1%1 tube$1002.54$1002.54

                      Typical dosing for Diclona Gel (diclofenac / lidocaine)

                      The typical dose is to apply a thin film of Diclona Gel (diclofenac / lidocaine) to the affected area, up to 4 times daily.

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                      How much does Diclona Gel (diclofenac / lidocaine) cost?

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                      contraindications-icon

                      Diclona Gel (diclofenac / lidocaine) contraindications

                      Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Diclona Gel (diclofenac / lidocaine) will not be safe for you to take.
                      • History of sensitivity to local anesthetics or diclofenac

                      • Coronary artery bypass graft (CABG) surgery

                      alternatives

                      What are alternatives to Diclona Gel (diclofenac / lidocaine)?

                      There are a number of medications that your doctor can prescribe in place of Diclona Gel (diclofenac / lidocaine). Compare a few possible alternatives below.
                      Diclona Gel (diclofenac / lidocaine)
                      Used for:

                      Pain, discomfort, and soreness caused by:

                      • Arthritis

                      • Backache

                      • Cramps

                      • Neckache

                      • Sprains

                      • Strains

                      $750.98 Lowest GoodRx priceView Prices
                      Used for:
                      • Minor burns

                      • Sunburns

                      • Minor cuts

                      • Scrapes

                      • Insect bites

                      • Minor skin irritations

                      • Joint and muscle pain

                      • Hemorrhoids and other irritations in the anal area

                      • Tattoos, piercings, microblading, and other skin procedures

                      $22.03 Lowest GoodRx priceView Prices
                      Used for:
                      • Pain from osteoarthritis of the knees - topical solutions and 1% gel

                      • Pain from osteoarthritis of small joints, such as hands and wrists - 1% gel only

                      $12.17 Lowest GoodRx priceView Prices

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