Calcium channel blocker-statin combinations are used to treat high blood pressure, high cholesterol, and angina (chest pain). These medications work by combining the effects of calcium channel blockers, which relax your blood vessels to lower blood pressure, and statins, which reduce cholesterol levels. These combinations are available in oral form. An example of this type of medication is amlodipine / atorvastatin (Caduet). This combination helps you manage multiple cardiovascular conditions with a single pill.