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Cinacalcet

Cinacalcet Side Effects

Allison Gourley, PharmDKristianne Hannemann, PharmD
Reviewed by Allison Gourley, PharmD, Kristianne Hannemann, PharmD
Last reviewed on June 12, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Nausea (29-66%)
  • Vomiting (26-52%)
  • Diarrhea (21%)

Less Common Side Effects

  • Stomach pain
  • Muscle aches
  • Dizziness
  • Poor appetite
  • Headache
  • Back pain

Cinacalcet serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Very low levels of calcium: muscle pain and spasms, pins and needles sensation, seizures
  • Stomach bleed: vomiting that won't stop, blood in your vomit or stool, black, tarry stools, really bad stomach pain
  • Heart problems: abnormal heartbeats, trouble breathing, sudden weight gain or swelling of your arms and legs, feeling confused

Source: DailyMed

The following Cinacalcet side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Blurred vision

chest pain

dizziness

headache

nervousness

pounding in the ears

slow or fast heartbeat

Less common

Convulsions

cough or hoarseness

fever or chills

loss of bladder control

lower back or side pain

muscle spasm or jerking of all extremities

painful or difficult urination

sudden loss of consciousness

Incidence not known

Abdominal or stomach cramps

confusion

decreased urine output

difficulty with breathing

difficulty with moving

dilated neck veins

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

extreme fatigue

fainting

irregular breathing

irregular heartbeats

joint pain

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

low bone turnover

mood or mental changes

muscle aching or cramping

muscle cramps in the hands, arms, feet, legs, or face

muscle pains or stiffness

numbness and tingling around the mouth, fingertips, or feet

sweating

swelling of the face, fingers, feet, or lower legs

swollen joints

tightness in the chest

tremor

troubled breathing

unusual tiredness or weakness

weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Diarrhea

lack or loss of strength

loss of appetite

nausea

vomiting

weight loss

Incidence not known

Hives or welts, itching, rash

redness of the skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Allison Gourley, PharmD, is a kidney and pancreas transplant pharmacist at a teaching hospital in the San Francisco Bay Area. When she’s not educating patients about their immunosuppressants, she's actively involved in transplant research.
Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.

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