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Chlorzoxazone Coupon - Chlorzoxazone 500mg tablet

chlorzoxazone

Generic Lorzone
Used for Musculoskeletal Conditions
Used for Musculoskeletal Conditions

Chlorzoxazone, also known by the now discontinued brand name Lorzone, is a muscle relaxant used to treat sudden muscle pain in adults, along with rest and physical therapy. It's thought to work by calming nerve signals that cause muscles to tighten or cramp. The medication comes in tablet form, and you'll typically take a dose by mouth three or four times a day. Though chlorzoxazone is generally well tolerated, side effects can include drowsiness, dizziness, and feeling lightheaded.

Reviewed by:
reviewer
Allison Gourley, PharmD
reviewer
Daisy Chau, PharmD
Last reviewed on April 1, 2025
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Chlorzoxazone?

What is Chlorzoxazone used for?

  • Muscle pain and discomfort caused by acute (short-term) conditions

How Chlorzoxazone works

Chlorzoxazone is a muscle relaxant. Experts aren't exactly sure how it works, but it doesn't seem to act directly on the muscles. It's thought to help by calming the nerves that make your muscles tighten or cramp, which can reduce pain and discomfort.

When does Chlorzoxazone start working?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsLorzone (brand name no longer available)
Drug ClassMuscle relaxant
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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Avg retail price
$70.26(save 57.22%)
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$30.06
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What are the side effects of Chlorzoxazone?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Drowsiness
  • Dizziness
  • Feeling lightheaded
  • General discomfort or feeling ill

Other Side Effects

  • Rash or other skin reaction
  • Discolored urine
  • Overstimulation

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Liver damage: dark urine, yellowing of the skin or eyes, upper right stomach pain, loss of appetite
  • Severe allergic reaction: hives, rash, redness, itching, trouble breathing

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

Bloody or black, tarry stools

clay-colored stools

constipation

cough

dark urine

decreased appetite

difficulty swallowing

dizziness

fast heartbeat

fever

headache

hives

itching

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

loss of appetite

nausea and vomiting

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

severe stomach pain

shortness of breath

skin rash

swelling of the feet or lower legs

tightness in the chest

unusual tiredness or weakness

vomiting of blood or material that looks like coffee grounds

wheezing

yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Diarrhea

difficult or troubled breathing

drowsiness

general feeling of discomfort or illness

headache

irregular, fast or slow, or shallow breathing

lightheadedness

nausea

pale or blue lips, fingernails, or skin

sluggishness

vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

Bruising

large, flat, blue, or purplish patches in the skin

small red or purple spots on the skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Chlorzoxazone

thumbs-up

Pros

Relieves muscle pain and spasms

Not a controlled substance

Usually well tolerated

thumbs-down

Cons

Can cause dizziness and drowsiness

Needs to be taken multiple times a day

Interacts with alcohol and other medications that cause sleepiness

pharmacist-tips

Pharmacist tips for Chlorzoxazone

pharmacist

  • Chlorzoxazone is usually meant for short-term muscle pain. Don’t use it longer than your prescriber tells you to.

    • Take chlorzoxazone at the same times each day, and try to space your doses evenly. As your pain improves, your prescriber might lower your dose.

      • Keep resting your muscles and doing physical therapy if recommended. Chlorzoxazone works best when used along with other treatments, not as a replacement.

        • Rarely, chlorzoxazone can change the color of your urine. This is harmless and goes away after you stop the medication.

          • Chlorzoxazone can cause drowsiness or dizziness. Don’t drive or use heavy machines until you know how it affects you.

            • Avoid alcohol while taking chlorzoxazone as it can make side effects like drowsiness and dizziness worse.

              • Watch for signs of liver problems while taking chlorzoxazone. Stop taking it and call your prescriber if you feel nauseous, tired, have dark urine, yellowing skin or eyes, or upper right stomach pain.

                • Talk to your prescriber before using chlorzoxazone if you’re pregnant or planning to become pregnant. It’s not known if this medication is safe during pregnancy, so it should only be used if your prescriber believes the benefits outweigh the risks.

                  faqs

                  Frequently asked questions about Chlorzoxazone

                  Can I take chlorzoxazone after a gastric bypass surgery?
                  Always talk with your healthcare team before taking new medications after a gastric bypass surgery. A research study found that taking chlorzoxazone after this type of surgery can cause your body to absorb more of the medication than usual. This might happen because the surgery could change how your body breaks down certain medications. To lower your chance of side effects or other problems, ask your prescriber if chlorzoxazone is safe for you to take after surgery.
                  Is chlorzoxazone a narcotic?
                  Though chlorzoxazone is considered a painkiller, it's not a narcotic. Narcotics usually refer to opioids, a specific class of medications.
                  Is chlorzoxazone a controlled substance?
                  No, chlorzoxazone isn't a controlled substance. This means it doesn't have a high risk of misuse and addiction.
                  What chlorzoxazone interactions should I know about?
                  Chlorzoxazone can interact with many other medications, so it's important to make sure your prescriber and pharmacist have a full list of your medications before you start. Be extra careful if you're taking other medications that can make you sleepy, especially if you need to drive or do anything that requires focus. Combining these medications can be dangerous.
                  Can you drink alcohol while you're taking chlorzoxazone?
                  Drinking alcohol while taking chlorzoxazone can make side effects like dizziness and drowsiness worse. This could put you at risk if you need to drive or do anything that requires concentration. To stay safe, it’s best to avoid alcohol while using chlorzoxazone.
                  Can you take chlorzoxazone with ibuprofen?
                  Yes, you can usually take chlorzoxazone with ibuprofen. These two medications work in different ways —ibuprofen helps reduce inflammation and pain, while chlorzoxazone is a muscle relaxant that helps calm muscle spasms. In fact, they are often prescribed together for muscle pain. But you should still check with your prescriber, especially if you have other health conditions or are taking other medications that could interact.
                  How long does it take for chlorzoxazone to kick in?
                  Chlorzoxazone starts to show up in the blood within 30 minutes and reaches its highest levels around 1 to 2 hours after taking it. But pain relief can vary from person to person. Some people might feel better quickly, while others might take a little longer depending on their health, condition, or other medications they’re taking. If you’re not noticing improvement after a few doses, it’s a good idea to check in with your prescriber.
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                  What are the risks and warnings for Chlorzoxazone?

                  Chlorzoxazone can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                  risk-warning

                  Liver damage

                  Although rare, serious liver damage (including life-threatening cases) has been reported with chlorzoxazone. Stop taking it and contact your prescriber right away if you notice fever, rash, loss of appetite, nausea, vomiting, tiredness, upper right stomach pain, dark urine, or yellowing of your skin or eyes. Your prescriber might also check your liver enzymes during treatment.

                  risk-warning

                  Interaction with alcohol and other medications

                  • Risk factors: Drinking alcohol | Taking medications that cause sleepiness

                    Don’t drink alcohol or take medications that make you sleepy — like sleep aids, anxiety medications, or strong painkillers — while taking chlorzoxazone unless your prescriber says it’s okay. Taking them together can make you extra sleepy, dizzy, or even slow your breathing, which can be dangerous. Always check with your prescriber or pharmacist before combining medications.

                    risk-warning

                    Allergic reactions

                    Use chlorzoxazone carefully if you’ve ever had an allergic reaction to medications. If you notice itching, redness, or hives, stop taking the medication and call your prescriber right away.

                    dosage

                    Chlorzoxazone dosage forms

                    The average cost for 90 tablets of 500mg of Chlorzoxazone is $30.06 with a free GoodRx coupon. This is 57.22% off the average retail price of $70.26.
                    tablet
                    Tablet
                    DosageQuantityPrice as low asPrice per unit
                    250mg30 tablets$121.97$4.07
                    375mg90 tablets$50.72$0.56
                    500mg90 tablets$30.06$0.33
                    750mg90 tablets$71.24$0.79

                    Typical dosing for Chlorzoxazone

                    The typical starting dose is 250 mg to 500 mg by mouth three or four times a day. The maximum dose is 750 mg by mouth three to four times a day.

                    interactions

                    Interactions between Chlorzoxazone and other drugs

                    Chlorzoxazone may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Chlorzoxazone. Please note that only the generic name of each medication is listed below.

                    Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                    Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                    • St John's Wort
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                    How much does Chlorzoxazone cost?

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                    Chlorzoxazone (generic)
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                    alternatives

                    What are alternatives to Chlorzoxazone?

                    There are a number of medications that your doctor can prescribe in place of Chlorzoxazone. Compare a few possible alternatives below.
                    Chlorzoxazone
                    Used for:

                    • Muscle pain and discomfort caused by acute (short-term) conditions

                    $30.06 Lowest GoodRx priceView Prices
                    Carisoprodol (Soma)
                    Used for:

                    • Discomfort caused by painful muscle-related conditions (short-term only)

                    $13.83 Lowest GoodRx priceView Prices
                    Methocarbamol
                    Used for:

                    • Muscle pain and discomfort caused by acute (short-term) conditions

                    • Muscle problems due to tetanus - injection form only

                    $8.40 Lowest GoodRx priceView Prices
                    images

                    Chlorzoxazone images

                    Green Round 555 585 And Barr - Chlorzoxazone 500mg Tablet
                    This medicine is Green, Round, Scored Tablet Imprinted With "555 585" And "Barr".Green Round 555 585 And Barr - Chlorzoxazone 500mg Tablet
                    White Oblong 39 68 And Wpi - Chlorzoxazone 500mg Tablet
                    This medicine is White, Oblong, Scored Tablet Imprinted With "39 68" And "Wpi".White Oblong 39 68 And Wpi - Chlorzoxazone 500mg Tablet
                    White Oblong N085 - Chlorzoxazone 500mg Tablet
                    This medicine is White, Oblong, Scored Tablet Imprinted With "N085".White Oblong N085 - Chlorzoxazone 500mg Tablet

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                    References

                    Best studies we found

                    Endo USA, Inc. (2024). Chlorzoxazone tablet [package insert]. DailyMed.

                    MedlinePlus. (2023). Pain medications - narcotics.

                    Puris, E., et al. (2019). Laparoscopic Roux-en-Y gastric bypass surgery influenced pharmacokinetics of several drugs given as a cocktail with the highest impact observed for CYP1A2, CYP2C8 and CYP2E1 substrates. Basic & Clinical Pharmacology & Toxicology.

                    GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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