Brinsupri
Brinsupri (brensocatib) is the first FDA approved medication to treat a life-long lung condition called non-cystic fibrosis bronchiectasis (NCFB) in people 12 years and older. It’s a dipeptidyl peptidase 1 (DPP-1) inhibitor that works to lower swelling and flare ups. It comes as a tablet that you take by mouth once a day. Common side effects include headache, upper respiratory tract infection, and rash.
What is Brinsupri (brensocatib)?
What is Brinsupri (brensocatib) used for?
- Non-cystic fibrosis bronchiectasis (NCFB) in people 12 years and older
How Brinsupri (brensocatib) works
Brinsupri (brensocatib) is a DPP-1 inhibitor, meaning it blocks an enzyme called dipeptidyl peptidase 1 (DPP-1). This enzyme normally “switches on” certain proteins in the lungs that can cause inflammation, extra mucus, and long‑term lung damage.
By stopping DPP‑1, Brinsupri (brensocatib) helps keep these proteins from becoming active. This can reduce inflammation in the lungs and lowers the chances of flare‑ups.
Drug facts
| Common Brands | Brinsupri |
|---|---|
| Drug Class | DPP-1 inhibitor |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
Side effects of Brinsupri (brensocatib)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Upper respiratory tract infection (27-29%)
- Headache (7-9%)
- Rash (4-6%)
- High Blood Pressure (2-5%)
- Dry skin (3-4%)
- Thickened skin (1-3%)
Less Common Side Effects
- Hair loss
- Higher liver enzyme levels
Brinsupri (brensocatib) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Skin problems: new rash, new lump, spot or growth on skin
- Dental problems: tooth or gum problems
The following Brinsupri (brensocatib) side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
Pros and cons of Brinsupri (brensocatib)
Pros
- Only taken once a day
- Safe for people 12 years and older
- First FDA-approved medication for NCFB
Cons
- May take several months to fully work
- Common side effects include headache, rash and dry or thickened skin
- Might interact with some medications
Pharmacist tips for Brinsupri (brensocatib)
- You can take Brinsupri (brensocatib) with or without food, as long as it’s taken at the same time each day. Food won't affect how it works in your body.
- If you ever miss a dose of Brinsupri (brensocatib), take your next dose at the regular time the next day. Don’t double the dose to make up for the missed one. It can help you remember to take your medications if you use a pill box, set alarms, or always take it with the same meal everyday.
- It’s not known whether getting a live vaccine while taking Brinsupri (brensocatib) will change how safe the vaccine is or how well it works. Talk to your prescriber before getting any vaccines while taking this medication.
- Brinsupri (brensocatib) can raise the risk of gum or tooth problems. See your dentist regularly during treatment. It’s also important to follow a daily oral care routine, which can include brushing your teeth at least twice a day, flossing regularly, and cleaning your tongue as well.
- Brinsupri (brensocatib) can cause skin problems, including rash or dry, flaky or thickened skin. If you notice a new rash or other skin problems, tell your prescriber. They might refer you to see a dermatologist for
- Brinsupri (brensocatib) can interact with certain medications, including over-the-counter products, vitamins, and herbal supplements. Let your prescriber know about everything you take so they can make sure it’s safe for you.
- Pregnancy: It’s not known if Brinsupri (brensocatib) is safe in pregnancy. Talk to your prescriber if you’re pregnant or plan to become pregnant while taking this medication.
- Store Brinsupri (brensocatib) in its original container in a cool dry area at room temperature.
Risks and warnings for Brinsupri (brensocatib)
Brinsupri (brensocatib) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Skin problems
Brinsupri (brensocatib) can cause skin problems, including rash, dry skin, and thickened skin. Watch for any new rashes or skin problems and let your prescriber know. They might refer you to a dermatologist for further treatment.
Dental problems
Brinsupri (brensocatib) can cause dental problems, which includes gum or teeth issues. That’s why it’s important to see your dentist regularly while taking this medication. Follow a good daily oral health routine, such as brushing at least twice a day, flossing, and brushing your tongue as well.
Vaccines
You should avoid live vaccines while taking Brinsupri (brensocatib) because it’s not known how they might interact. It’s a good idea to check with your prescriber before getting any vaccines while taking this medication.
Brinsupri (brensocatib) dosage
Typical dosage for Brinsupri (brensocatib)
The typical dose is one tablet (10 mg or 25 mg) by mouth once a day.
Brinsupri (brensocatib) images
