FDA Approves New Injection for Osteoarthritis

Roni Shye
Roni Shye, PharmD BCGP BCACP, is a licensed pharmacist in the states of Florida, Ohio, and Pennsylvania.
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Osteoarthritis, also known as degenerative joint disease or OA, is the most common form of arthritis. It can cause severe and debilitating pain as the cartilage begins to wear away.

OA can be treated with over-the-counter oral medications like Tylenol (acetaminophen) or Motrin (ibuprofen). It can also be treated with prescription pain medications, and we have a new one to add to the list—Zilretta.

What is Zilretta indicated for?

Zilretta is an extended-release synthetic corticosteroid injection for the management of osteoarthritis pain of the knee.

Who is at risk for osteoarthritis?

Anyone can be at risk for OA, but females, individuals with joint injuries or bone deformities, older adults, or those with a genetic predisposition may have a higher chance of developing OA.

How does Zilretta work?

You will receive Ziretta as a single intra-articular injection into the knee by your healthcare provider. Zilretta works by slowly releasing the medicine over a period of 12 weeks. It is not intended for repeated administration.

Zilretta is the first and only extended-release, intra-articular injection for osteoarthritis knee pain. Using an injection like Zilretta for osteoarthritis knee pain offers an innovative non-opioid therapy, proven to deliver pain relief over 12 weeks.

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What are the most common side effects associated with Zilretta?

The most common side effects include sinusitis, cough, and bruised skin.

Are there any other similar injections?

Kind of. There are other injections available for osteoarthritis of the knee. However, they are not expected to last as long as Zilretta. Other injections include Hyalgan, Synvisc and Euflexxa.

For more information on Zilretta, see the press announcement from the manufacturer here, and the website for Zilretta here.

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