diphenhydramine / phenylephrine
Benadryl Plus Congestion is a combination of two medications: diphenhydramine (an antihistamine) and phenylephrine (a decongestant). It's an over-the-counter medication for adults and children that can treat symptoms of allergy and the common cold. This medication is taken by mouth, typically every 4 hours as needed. The combination of medications (diphenhydramine and phenylephrine) can also be found as generic tablets and liquid. Some side effects of Benadryl Plus Congestion (diphenhydramine / phenylephrine) include sleepiness, dizziness, and dry mouth.
What is Benadryl Plus Congestion (diphenhydramine / phenylephrine)?
What is Benadryl Plus Congestion (diphenhydramine / phenylephrine) used for?
Short-term relief of symptoms from allergies and the common cold:
Runny nose
Sneezing
Itchy nose or throat
Itchy, watery eyes
Stuffy nose (nasal congestion)
Sinus congestion and pressure
How Benadryl Plus Congestion (diphenhydramine / phenylephrine) works
Benadryl Plus Congestion (diphenhydramine / phenylephrine) is a combination of two medications that work together to relieve symptoms caused by allergies and the common cold.
Diphenhydramine is a first-generation antihistamine. It blocks a natural substance in your body called histamine. In doing so, diphenhydramine lowers inflammation (swelling) and relieves runny nose, itchy nose, and sneezing.
Phenylephrine is a decongestant. It's thought to work by narrowing the blood vessels in the nose to relieve sinus pressure.
Drug Facts
What are the side effects of Benadryl Plus Congestion (diphenhydramine / phenylephrine)?
Common Side Effects
- Sleepiness
- Restlessness
- Dizziness
- Dry mouth, nose, or throat
Other Side Effects
- Trouble urinating
- Nausea
- Vomiting
- Headache
Source:Â DailyMed
Pros and cons of Benadryl Plus Congestion (diphenhydramine / phenylephrine)
Pros
Combines two medications into one product for convenience
Can relieve multiple allergy and common cold symptoms
Available over the counter and as a generic tablet and liquid
Cons
Might need to take as often as every 4 hours for symptom relief
More difficult to customize the dose since Benadryl Plus Congestion (diphenhydramine / phenylephrine) is a fixed combination of two medications
Might not be a good choice for people over 65 years old or people with glaucoma, breathing problems, stomach problems, or urinary problems
Pharmacist tips for Benadryl Plus Congestion (diphenhydramine / phenylephrine)
The diphenhydramine in Benadryl Plus Congestion (diphenhydramine / phenylephrine) can make you feel sleepy or dizzy during the day. This can affect your ability to think or react. Don't drive or do any task that needs a lot of focus until you know how the medication affects you. Also, don't drink alcohol because it can make you more tired and dizzy.
Don't use Benadryl Plus Congestion (diphenhydramine / phenylephrine) to make your child sleepy. While this medication usually makes adults sleepy, it can have the opposite effect in children and make them hyper. If your child is having trouble sleeping, contact their pediatrician or pharmacist for other options.
Benadryl Plus Congestion (diphenhydramine / phenylephrine) is only meant to relieve cold symptoms temporarily. If your symptoms worsen or last longer than a week, or you start to have a fever or rash, let your healthcare team know. These might be signs that you need more medical attention.
Stop taking Benadryl Plus Congestion (diphenhydramine / phenylephrine) and contact your healthcare team if you experience dizziness, nervousness, or trouble sleeping. These might be side effects from the phenylephrine or other medications in Benadryl Plus Congestion (diphenhydramine / phenylephrine). Depending on how severe your symptoms are, your care team might ask you to consider alternative medications.
Don't start any new medications while taking Benadryl Plus Congestion (diphenhydramine / phenylephrine), especially other antihistamines or decongestants, without talking to your HCP or pharmacist first. Doing so can raise your risk of overdose and severe side effects, including seizures, hallucinations (seeing things that are not real), daytime sleepiness, dizziness, high blood pressure, or even death.
Don't take Benadryl Plus Congestion (diphenhydramine / phenylephrine) with a monoamine oxidase inhibitor (MAOI), such as selegiline, phenelzine (Nardil), or tranylcypromine (Parnate). This combination can cause high blood pressure. If you've taken an MAOI in the past 2 weeks, contact your prescriber for other options to treat your symptoms.
If you're pregnant or breastfeeding, don't take Benadryl Plus Congestion (diphenhydramine / phenylephrine) until you've talked to a HCP first about the risks and benefits of taking this medication. It's not clear how safe it is to take Benadryl Plus Congestion (diphenhydramine / phenylephrine) while pregnant or breastfeeding.
More tips for the Benadryl Plus Congestion (diphenhydramine / phenylephrine) liquid:
Store the Benadryl Plus Congestion (diphenhydramine / phenylephrine) liquid at room temperature. Keep it in the original bottle to protect it from light.
If you're using a liquid form of Benadryl Plus Congestion (diphenhydramine / phenylephrine), use the medication dose cup or syringe that came with the product to measure your dose. Don't use household spoons because they aren't accurate and might cause you to take the wrong dose.
Some Benadryl Plus Congestion (diphenhydramine / phenylephrine) liquids contain sodium. Ask a member of your care team if it's okay to use Benadryl Plus Congestion (diphenhydramine / phenylephrine) liquid if you're supposed to be on a low-sodium diet because of medical conditions like heart failure or kidney problems.
Frequently asked questions about Benadryl Plus Congestion (diphenhydramine / phenylephrine)
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What are the risks and warnings for Benadryl Plus Congestion (diphenhydramine / phenylephrine)?
Benadryl Plus Congestion (diphenhydramine / phenylephrine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Sleepiness
Risk factors: Alcohol use | Taking other medications that cause sleepiness | Age 65 or older
Benadryl Plus Congestion (diphenhydramine / phenylephrine) can make you very sleepy, which can affect your ability to focus, think, or react. This side effect is more likely to happen or be more intense if you're 65 years or older, drink alcohol while taking this medication, or take other medications that cause sleepiness (e.g., opioids, benzodiazepines, sleep medications). Don't drive or operate machinery until you know how Benadryl Plus Congestion (diphenhydramine / phenylephrine) affects you.
Worsening of medical conditions
Risk factors: Glaucoma | Heart disease or high blood pressure | Thyroid disease | High blood sugar (diabetes) | Breathing problems | Urinary problems
Benadryl Plus Congestion (diphenhydramine / phenylephrine) might worsen certain medical conditions. This medication might not be appropriate for you if you have certain medical conditions, such as glaucoma, high blood pressure, breathing problems, and urinary problems. This medication also might not be safe if you're taking certain medications, such as opioids, or other antihistamines and decongestants. Before taking Benadryl Plus Congestion (diphenhydramine / phenylephrine), let your healthcare professional know about what other medical conditions you have and ask if this medication is safe for you.
Accidental overdose
Benadryl Plus Congestion (diphenhydramine / phenylephrine) contains an antihistamine (diphenhydramine) and a decongestant (phenylephrine), which are all in many other over-the-counter products. Taking more than one medication containing an antihistamine or decongestant can lead to an accidental overdose, which can be life-threatening.
To prevent an accidental overdose, read the medication box and package labels carefully so you're aware of the ingredients, age-cut offs, and maximum dosing of your particular product. If you're not sure, ask your pharmacist to help you check for medication interactions.
Some signs of taking too much medication can include agitation or other behavior changes or high blood pressure. If you or your loved one experiences an accidental overdose, get medical help as soon as possible.
Benadryl Plus Congestion (diphenhydramine / phenylephrine) dosage forms
| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 25mg/10mg | 30 tablets | $10.49 | $0.35 |
Typical dosing for Benadryl Plus Congestion (diphenhydramine / phenylephrine)
Diphenhydramine / phenylephrine combinations are made by several manufacturers. Be sure to check the medication box or ask your pharmacist for specific instructions. Some examples are listed below.
Benadryl Allergy Plus Congestion: Each tablet contains 25 mg of diphenhydramine and 10 mg of phenylephrine.
Adults and children ages 12 years and older: The typical dose is 1 tablet by mouth every 4 hours while you're having symptoms. Don't use more than 6 tablets in a 24-hour period.
Children under 12 years old: Ask your child's pediatrician.
Children's Benadryl Allergy Plus Congestion: Each 5 mL contains 12.5 mg of diphenhydramine and 5 mg of phenylephrine.
Adults and children ages 12 years and older: The typical dose is 10 mL by mouth every 4 hours while you're having symptoms. Don't take more than 60 mL in a 24-hour period.
Children ages 6 to under 12 years old: The typical dose is 5 mL by mouth every 4 hours while you're having symptoms. Don't take more than 30 mL in a 24-hour period.
Children under 6 years old: Ask your child's pediatrician.
How much does Benadryl Plus Congestion (diphenhydramine / phenylephrine) cost?
Benadryl Plus Congestion (diphenhydramine / phenylephrine) contraindications
Currently take or have taken a monoamine oxidase inhibitor (MAOI) in the last 2 weeks
What are alternatives to Benadryl Plus Congestion (diphenhydramine / phenylephrine)?
Short-term relief of symptoms from allergies and the common cold:
Runny nose
Sneezing
Itchy nose or throat
Itchy, watery eyes
Stuffy nose (nasal congestion)
Sinus congestion and pressure
Runny nose
Sneezing
Itching of the nose or throat
Itchy or watery eyes
Nasal and sinus congestion
Runny nose
Sneezing
Itchy nose or throat
Itchy, watery eyes
Stuffy nose (nasal congestion)
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References
Best studies we foundGelotte, C. K., et al. (2015). Pharmacokinetics, safety, and cardiovascular tolerability of phenylephrine HCl 10, 20, and 30 mg after a single oral administration in healthy volunteers. Clinical Drug Investigation.
Hoeft, D. (2014). An overview of clinically significant drug interactions between medications used to treat psychiatric and medical conditions. Mental Health Clinician.
Johnson & Johnson Consumer Inc. (2024). Benadryl Allergy Plus Congestion- diphenhydramine hydrochloride and phenylephrine hydrochloride tablet, film coated [package insert]. DailyMed.
Johnson & Johnson Consumer Inc. (2024). Childrens Benadryl Allergy Plus Congestion- diphenhydramine hydrochloride and phenylephrine hydrochloride solution [package insert]. DailyMed.
Walgreen Company. (2024). Sinus PE Congestion- diphenhydramine hcl, phenylephrine hcl kit [package insert]. DailyMed.
Walgreens. (2023). Cold and Congestion Childrens Nighttime- diphenhydramine hci, phenylephrine hcl liquid [package insert]. DailyMed.
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