Azmiro
Azmiro (testosterone cypionate) is a prescription injection used to treat males with low testosterone. It's a type of testosterone replacement therapy that raises your testosterone levels to healthy levels and improves symptoms like low energy, reduced sex drive, mood changes, and muscle loss. The injection goes deep into the buttock muscle and is given by a healthcare professional, usually every 2 to 4 weeks. Some side effects include injection site reactions, headache, and higher red blood cell counts.
What is Azmiro (testosterone cypionate)?
What is Azmiro (testosterone cypionate) used for?
- Low testosterone (also called hypogonadism)
How Azmiro (testosterone cypionate) works
Azmiro (testosterone cypionate) is a testosterone replacement therapy that acts like the natural hormone testosterone. Testosterone helps support many male traits and functions, such as muscle and bone strength, sex drive, and sperm production.
Azmiro (testosterone cypionate) works by raising testosterone levels back to a normal and healthy range in males with low testosterone.
Drug facts
| Common Brands | Azmiro |
|---|---|
| Drug Class | Testosterone replacement |
| Controlled Substance Classification | Schedule III |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
Risks and warnings for Azmiro (testosterone cypionate)
Azmiro (testosterone cypionate) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Higher red blood cell count
Azmiro (testosterone cypionate) can raise your red blood cell count, which can lead to blood clots. Your prescriber will check your red blood cell levels before you start treatment and during it. If your levels get too high, you might have to stop the medication until they go back to normal.
Blood clots
Azmiro (testosterone cypionate) itself can cause life-threatening blood clots in your legs or lungs. If you notice leg pain, swelling, warmth, or redness, tell your prescriber right away, as these could be signs of a blood clot in your leg. If you suddenly have trouble breathing or chest pain, it could mean a clot has moved to your lungs. If this happens, you might have to stop taking the medication.
Worsening of enlarged prostate and risk of prostate cancer
- Risk factors: History of enlarged prostate
Taking Azmiro (testosterone cypionate) can worsen certain symptoms if you have an enlarged prostate, also called benign prostatic hyperplasia (BPH). Let your prescriber know if you notice changes in urination, such as going more often at night, feeling like you need to go right away, having trouble starting, leaking, or a weak stream.
Azmiro (testosterone cypionate) might also raise your risk of prostate cancer. Your prescriber might order blood tests or check your prostate before and during treatment to help keep you safe.
Higher blood pressure
- Risk factors: History of high blood pressure
Azmiro (testosterone cypionate) can raise your blood pressure. Having high blood pressure over time can raise your risk for heart problems, like heart attack or stroke.
Get emergency help right away if you have chest pain, cold sweats, left arm pain, trouble breathing, trouble walking, trouble speaking, or weakness on one side of the body. You should check your blood pressure often while you’re using this medication, especially if you already have high blood pressure.
Potential for misuse, addiction, and dependency
- Risk factors: Taking more Azmiro (testosterone cypionate) than prescribed | Taking Azmiro (testosterone cypionate) with other testosterones
Azmiro (testosterone cypionate) is a controlled substance because it can be misused or cause dependence, especially if you take higher doses than prescribed or combine it with other testosterone products.
Misusing Azmiro (testosterone cypionate) can lead to addiction. This medication is only approved by the FDA to treat low testosterone in men. Taking Azmiro (testosterone cypionate) for other reasons can cause serious heart and mental health problems. Always use it exactly as prescribed.
Lower sperm count
- Risk factors: Taking more Azmiro (testosterone cypionate) than prescribed
Azmiro (testosterone cypionate) can lower sperm count, which might make it harder to have a baby. This is more likely with higher doses, and the effect could be permanent. Tell your prescriber if you plan to have children before starting this medication.
Liver problems
Using certain forms of testosterone, such as methyltestosterone or testosterone enanthate intramuscular injection, for a long time can cause serious liver problems. This isn't a known risk of Azmiro (testosterone cypionate), but it's still important to look out for symptoms of liver damage. Let your prescriber know if you have stomach pain, pale stools, dark urine, or yellowing of your skin or eyes.
Swelling in the arms and legs (edema)
- Risk factors: History of heart, liver, or kidney conditions | Taking other medications that cause swelling like corticosteroids
Azmiro (testosterone cypionate) can make your body keep extra salt and water, which might lead to edema, or swelling in your arms and legs. This is more likely if you take other medications that cause swelling, like corticosteroids (e.g., prednisone, methylprednisolone). Swelling can be more serious if you have heart, liver, or kidney problems. Tell your prescriber if you notice these symptoms.
Breathing problems during sleep (sleep apnea)
- Risk factors: Obesity | History of lung problems
Azmiro (testosterone cypionate) can make sleep apnea, a condition that causes breathing problems during sleep, worse in some people. This is more likely if you have obesity or lung problems. Talk to your prescriber if you or your partner notice loud snoring, pauses in breathing during sleep, or if you feel very tired during the day.
Enlarged breasts
Some people using Azmiro (testosterone cypionate) might develop gynecomastia, which is swelling or enlargement of breast tissue in men. You might also feel soreness or pain in your chest area. Talk to your prescriber if you have questions about this side effect.
Changes in cholesterol levels
Testosterone treatments like Azmiro (testosterone cypionate) can affect your cholesterol levels. Your prescriber might need to adjust your dose or stop the medication if these changes happen. They will check your cholesterol regularly, especially when you first start using the medication.
High calcium levels
- Risk factors: History of cancer
Azmiro (testosterone cypionate) can raise calcium levels in your blood and urine, especially in people with cancer. High calcium levels can cause symptoms such as muscle weakness, frequent urination, thirst, stomach pain, and blood in the urine. Your prescriber might check your blood regularly during treatment to make sure your calcium levels stay normal.
Effects on growing bones in children
- Risk factors: Young children
Azmiro (testosterone cypionate) can affect bone growth in children. It can cause the bones to mature too quickly, which can make the growth plates close early. This can lead to a shorter adult height. The younger the child, the higher the risk. If your child is using this medication, their care team should check bone growth every 6 months by taking X-rays of the wrist and hand to make sure the bones are developing safely.
Side effects of Azmiro (testosterone cypionate)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Injection site reactions
- Higher red blood cell count
- Enlarged breasts
- Headache
- Depression
Less Common Side Effects
- Problems with erections
Azmiro (testosterone cypionate) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Heart attack: chest pain, cold sweats, left arm pain, difficulty breathing
- Stroke: face drooping, trouble seeing, walking, or speaking, weakness on one side of the body
- Blood clot in the legs: pain, swelling, warm to touch, redness
- Blood clot in the lungs: trouble breathing, chest pain, cough
- Liver damage: stomach pain, nausea, vomiting, yellowing of the skin, yellowing of the whites of the eyes, light-colored stools, dark urine, weight loss
- Withdrawal: depression, fatigue, craving, restlessness, irritability, lack of appetite, trouble sleeping, lowered sex drive, low testosterone
The following Azmiro (testosterone cypionate) side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Get emergency help immediately if any of the following symptoms of overdose occur:
Symptoms of overdose
Blurred vision
headache
seizures
slurred speech
sudden and severe inability to speak
temporary blindness
weakness in the arm or leg on one side of the body, sudden and severe
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Gum or mouth irritation
Less common
Bad, unusual, or unpleasant (after) taste
bleeding gums
blemishes on the skin
breast pain
change in taste
crying
depersonalization
discouragement
dizziness
dysphoria
enlarged breasts
euphoria
fear or nervousness
feeling sad or empty
gum pain or blisters
hoarseness
indigestion
irritability
itching skin
loss of appetite
loss of interest or pleasure
lower back or side pain
mouth ulcers
noisy breathing
painful or difficult urination
paranoia
passing of gas
pounding in the ears
quick to react or overreact emotionally
rapidly changing moods
redness and swelling of the gums
slow or fast heartbeat
stinging of the lips
stomach cramps, pain, fullness, or discomfort
swelling of the gums
swelling of the nose
tiredness
toothache
trouble concentrating
trouble sleeping
unusual tiredness or weakness
vomiting
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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Pros and cons of Azmiro (testosterone cypionate)
Pros
- Injected once every 2 to 4 weeks
- Comes as a vial or prefilled syringe
- Helps with energy, muscle mass, mood, and sex drive
Cons
- Must be injected by a healthcare professional
- Risk of heart and prostate problems
- Need regular lab tests
Pharmacist tips for Azmiro (testosterone cypionate)
- Azmiro (testosterone cypionate) is injected by a healthcare professional deep into your buttock muscle once every 2 to 4 weeks.
- Get all your lab tests done while you use Azmiro (testosterone cypionate). Your prescriber will check things like your testosterone level and red blood cell count to be sure the medication is safe and working well.
- Watch for signs of a blood clot while using Azmiro (testosterone cypionate), such as pain, swelling, or redness in your legs. Get medical help right away if you have chest pain or trouble breathing, as these could be signs of a clot in your lungs.
- Azmiro (testosterone cypionate) can raise your blood pressure, which might increase your risk for heart problems over time. You might want to check your blood pressure regularly. Let your care team know if it goes up because your blood pressure treatment might need to be adjusted.
- Azmiro (testosterone cypionate) can sometimes cause gynecomastia, or enlarged breasts in males. Tell your prescriber if you notice changes in your chest area.
- Azmiro (testosterone cypionate) can lower your blood sugar. If you have diabetes, you might need to check your blood sugar more often. Know how to manage low blood sugar if this happens.
- Azmiro (testosterone cypionate) can cause changes in your urination, especially if you already have an enlarged prostate. Tell your care team if you start urinating more at night, have trouble starting to urinate, or have a weak stream.
Azmiro (testosterone cypionate) dosage
Syringe| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 1ml of 200mg/ml | 4 syringes | $1,008.80 | $252.20 |
Interactions between Azmiro (testosterone cypionate) and other drugs
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Anisindione
- Bupropion
- Dicumarol
- Paclitaxel
- Paclitaxel Protein-Bound
- Phenprocoumon
- Warfarin
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Licorice
How much does Azmiro (testosterone cypionate) cost?
$1,008.80
Azmiro (testosterone cypionate) contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Azmiro (testosterone cypionate) will not be safe for you to take.
- Men with breast or prostate cancer
- Women who are pregnant
What are alternatives to Azmiro (testosterone cypionate)?
Azmiro (testosterone cypionate) images
