Who makes Attruby (acoramidis)?

Attruby (acoramidis) is made by [BridgeBio Pharma Inc](https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshot-attruby).

When was Attruby (acoramidis) approved?

The FDA approved Attruby (acoramidis) in [November 2024](https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-drug-heart-disorder-caused-transthyretin-mediated-amyloidosis). It helps treat an inherited heart condition in adults called [ATTR-CM](https://www.heart.org/en/health-topics/cardiomyopathy/what-is-cardiomyopathy-in-adults/transthyretin-amyloid-cardiomyopathy-attr-cm). ATTR-CM is short for cardiomyopathy of transthyretin-mediated amyloidosis.

How long does Attruby (acoramidis) take to work?

Attruby (acoramidis) takes time to work in your body. Studies show that it starts to work best [almost 1 month](https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=913552ef-875d-4cb7-bf05-a7d20a394c38&type=display#section-12:~:text=was%20observed%20as%20early%20as%20Day%2028) after you begin treatment. But generally, it [works over a long time](https://www.nejm.org/doi/10.1056/NEJMoa2305434?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed) to improve symptoms. This includes helping you walk farther before getting out of breath and slowing [symptoms](https://www.heart.org/en/health-topics/cardiomyopathy/what-is-cardiomyopathy-in-adults/transthyretin-amyloid-cardiomyopathy-attr-cm), like shortness of breath, from getting worse. It might take [months](https://pmc.ncbi.nlm.nih.gov/articles/PMC11875408/) or even a couple years to notice overall benefit, including a lower risk of hospital stays or death due to heart problems. Keep following up with your heart specialist or prescriber. They can check how well Attruby (acoramidis) is working. Ask them if you have questions about what to expect.

What's the difference between Attruby and Vyndamax?

[Attruby (acoramidis)](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=913552ef-875d-4cb7-bf05-a7d20a394c38) and [Vyndamax (tafamidis)](https://www.goodrx.com/vyndaqel/what-is) are both [treatment options](https://www.goodrx.com/conditions/hereditary-transthyretin-mediated-amyloidosis/hereditary-attr-amyloidosis-treatment) for [ATTR-CM](https://www.heart.org/en/health-topics/cardiomyopathy/what-is-cardiomyopathy-in-adults/transthyretin-amyloid-cardiomyopathy-attr-cm), an inherited heart condition. They belong to the same drug class called [TTR stabilizers](https://www.goodrx.com/classes/ttr-stabilizers), meaning they work in similar ways. But they do have a few key differences, such as how often they're taken. Attruby is taken by mouth twice a day, whereas Vyndamax is taken by mouth once a day. Talk to a heart specialist to compare the medications and decide which is best for you.

Attruby

acoramidis

Used for Hereditary Transthyretin-Mediated Amyloidosis

Attruby (acoramidis) is approved for adults to treat a heart muscle condition called cardiomyopathy caused by wild‑type or variant transthyretin‑mediated amyloidosis (ATTR‑CM). It helps lower the risk of death and hospitalizations related to heart problems. Attruby (acoramidis) works as a transthyretin stabilizer. This medication comes as tablets that you take by mouth twice a day. Common side effects include diarrhea and upper stomach pain.

Reviewed by:

Kristianne Hannemann, PharmD

Cydnee Ng, PharmD

Last reviewed on February 9, 2026

What is Attruby (acoramidis)?

What is Attruby (acoramidis) used for?

Transthyretin amyloid cardiomyopathy (ATTR‑CM) in adults

How Attruby (acoramidis) works

Attruby (acoramidis) is a transthyretin (TTR) stabilizer. It works by attaching to proteins called transthyretin, which are shaped abnormally in people with ATTR-CM. This helps stop the abnormal proteins from building up in the heart walls. With less deposits in the heart walls, it makes it easier for the heart to pump blood through the body.

When does Attruby (acoramidis) start working?Time passed since treatment started:

HOURS

DAYS

WEEKS

Initial effect

MONTHS

Full effect

Drug facts

Common Brands	Attruby
Drug Class	TTR stabilizer
Controlled Substance Classification	Not a controlled medication
Generic Status	No lower-cost generic available
Availability	Prescription only

Common Brands

Attruby

Drug Class

TTR stabilizer

Controlled Substance Classification

Not a controlled medication

Generic Status

No lower-cost generic available

Availability

Prescription only

Side effects of Attruby (acoramidis)

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Diarrhea (12%)
Upper stomach pain (6%)

Less Common Side Effects

Change in kidney function tests

Source: DailyMed

The following Attruby (acoramidis) side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

Diarrhea
Stomach pain

Pros and cons of Attruby (acoramidis)

Pros

Can take at home
Side effects are usually mild
Shown to lower the risk of heart-related hospitalization and death

Cons

Need to take twice a day
Can cause diarrhea and stomach pain
Not approved for children

Pharmacist tips for Attruby (acoramidis)

Take Attruby (acoramidis) twice a day exactly as prescribed. Each tablet contains 356 mg of acoramidis. So, you'll need to take two tablets each time for a full dose of 712 mg.
Swallow Attruby (acoramidis) tablets whole with water. Don’t cut, crush, or chew them. This is because it can affect how the tablets release medication and how the medication works.
You can take Attruby (acoramidis) with or without food. If it upsets your stomach, try taking it with a snack next time to make it easier on your gut.
Diarrhea and stomach pain can happen while taking Attruby (acoramidis). If this happens, be sure to drink plenty of fluids to stay hydrated. Avoiding spicy or fried foods might help too. Call your care team if these side effects don't go away or are severe. They can provide more help, like suggesting medications for diarrhea. These tips can help you feel better and stay on track with your treatment.
Tell your care team about all the medications and supplements you take. They can check for any drug interactions with Attruby (acoramidis). Some medications, like certain seizure medications and St. John's wort, can lower the amount of Attruby (acoramidis) in the body. This can make it work less well. If needed, you might need to avoid certain medications or switch to other safer options.
Keep the Attruby (acoramidis) tablets in the original blister card until you need to take them. This helps protect the tablets from moisture. Store the medication at room temperature (68°F to 77°F).

Common questions about Attruby

Attruby is made by BridgeBio Pharma Inc.

The FDA approved Attruby in November 2024. It helps treat an inherited heart condition in adults called ATTR-CM. ATTR-CM is short for cardiomyopathy of transthyretin-mediated amyloidosis.

Attruby takes time to work in your body. Studies show that it starts to work best almost 1 month after you begin treatment. But generally, it works over a long time to improve symptoms. This includes helping you walk farther before getting out of breath and slowing symptoms, like shortness of breath, from getting worse. It might take months or even a couple years to notice overall benefit, including a lower risk of hospital stays or death due to heart problems. Keep following up with your heart specialist or prescriber. They can check how well Attruby is working. Ask them if you have questions about what to expect.

No, you shouldn't cut Attruby in half. You also shouldn't crush or chew the tablets. The medication is meant to be swallowed whole so that it works as it should. If you have trouble swallowing the tablets whole, speak with your prescriber.

If you're pregnant or thinking of becoming pregnant, talk to your prescriber. There isn't enough information to know if Attruby is safe during pregnancy. Your prescriber can help explain the risks and benefits of treatment. If you become pregnant while taking this medication, call your prescriber. Your can also call the manufacturer at 1-844-550-2246 to report your pregnancy.

If you're breastfeeding or want to breastfeed, speak with your prescriber. We don't know if Attruby can pass into breast milk. We also don't know what effects it could have on milk supply or a breastfed baby. Talk to your prescriber or a lactation expert about safe feeding options.

Attruby and Vyndamax (tafamidis) are both treatment options for ATTR-CM, an inherited heart condition. They belong to the same drug class called TTR stabilizers, meaning they work in similar ways. But they do have a few key differences, such as how often they're taken. Attruby is taken by mouth twice a day, whereas Vyndamax is taken by mouth once a day. Talk to a heart specialist to compare the medications and decide which is best for you.