What is the main side effect of Xarelto?

Since Xarelto is a blood thinner, bleeding is the most common side effect when taking it. You may be at a greater risk of bleeding if you have a history of bleeding, have medical conditions such as high blood pressure, kidney disease, or diabetes, take other medications that make bleeding more likely, such as aspirin or certain antidepressants, or are over the age of 65. Bleeding from Xarelto is usually mild. Nose bleeds, light bruising, or bleeding from the gums while brushing your teeth are examples of mild bleeding. It’s best to let your prescriber know if you experience mild bleeding symptoms. They may decide to monitor you more often. Sometimes, bleeding from Xarelto can be severe or even life-threatening. Signs of serious bleeding include bleeding that doesn’t stop, bruising that happens without a known cause or covers a large area, blood in your urine, blood in your stool (either bright red or black, tarry stool), coughing up blood, or vomiting blood (may look like coffee grounds). Seek medical attention immediately if you experience any of these symptoms. There are treatments available to help reverse life-threatening bleeding, such as Andexxa (andexanet alfa). These treatments are given in a hospital setting.