What should you avoid while taking Xarelto?

Xarelto (rivaroxaban) can interact with other medications that raise your bleeding risk. This includes other blood thinners, nonsteroidal anti-inflammatory drugs (NSAIDs), and some antidepressants. It’s best to avoid taking Xarelto with these medications unless your prescriber OKs it. Other Xarelto interactions include ketoconazole, Norvir (ritonavir), and Paxlovid (nirmatrelvir / ritonavir). These medications can increase Xarelto levels in the body, which can raise your risk of bleeding. Some anti-seizure medications and supplements like St. John’s wort can make Xarelto less effective, which can raise your risk of blood clots.