Is Sotyktu the same as Otezla?

No. Sotyktu (deucravacitinib) is not the same as Otezla (apremilast). Both are oral medications that can treat plaque psoriasis. But Otezla can also treat psoriatic arthritis and mouth sores that are caused by Behçet’s disease. Sotyktu and Otezla also belong to different medication classes. Sotyktu is a type of Janus kinase (JAK) inhibitor called a tyrosine kinase 2 (TYK2) inhibitor. Otezla is a phosphodiesterase-4 (PDE-4) inhibitor. Each medication blocks different proteins that contribute to inflammation.