11 Hereditary Angioedema Treatments: Berinert, Orladeyo, and More
Hereditary angioedema is a rare genetic disorder. Hereditary angioedema treatment may involve C1-INH replacement therapy and medications for related symptoms.
Andembry
Used for Hereditary Angioedema
Used for Hereditary Angioedema
Andembry (garadacimab or garadacimab-gxii) is an injectable medication used to help prevent hereditary angioedema (HAE) attacks in adults and children 12 years and older. It works as a factor XIIa inhibitor to block the pathway that causes HAE attacks in your body. Andembry (garadacimab) is injected under the skin using a prefilled syringe or autoinjector. After a one-time "loading” dose, it's given once a month. Common side effects include runny or stuffy nose and stomach pain. Injection site reactions like redness or itching can also happen.
What is Andembry (garadacimab)?
What is Andembry (garadacimab) used for?
- Prevention of hereditary angioedema (HAE) attacks in people 12 years and older
How Andembry (garadacimab) works
Andembry (garadacimab) is a type of monoclonal antibody called a factor XII inhibitor. It blocks a protein in the body called activated factor XII (FXIIa).
In people with HAE, this protein helps start a chain reaction that leads to too much bradykinin. Bradykinin is a natural chemical that causes swelling and pain during an HAE attack.
By blocking FXIIa, Andembry (garadacimab) helps stop this chain reaction from happening. This lowers bradykinin levels and helps prevent HAE attacks.
When does Andembry (garadacimab) start working?Time passed since treatment started:
Drug facts
| Common Brands | Andembry |
|---|---|
| Drug Class | Factor XII inhibitor |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
Side effects of Andembry (garadacimab)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Symptoms of an upper respiratory tract infection (e.g., runny nose, sneezing, stuffy nose; 21%)
- Stomach pain (8%)
Less Common Side Effects
- Injection site reactions (e.g., bruising, redness, itchiness, rash)
- Changes in blood clotting test results
When do Andembry (garadacimab) possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Injection site reaction
The following Andembry (garadacimab) side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Pain, redness, irritation, or bruising at the injection site
- Runny or stuffy nose
- Sneezing
- Sore throat
- Stomach pain
Get your GoodRx coupon
N/A
GoodRx discount
$60477.40
Pros and cons of Andembry (garadacimab)
Pros
- Given once a month
- Can self inject at home after training
- Option of autoinjector or prefilled syringe devices
Cons
- Not for treating an HAE attack once it starts; you’ll still need rescue medication on hand
- Must give as an injection under the skin
- Not approved for children under 12 years old
Pharmacist tips for Andembry (garadacimab)
- Andembry (garadacimab) helps prevent HAE attacks. It doesn't treat an attack once it starts. Always keep your on‑demand “rescue” treatment with you and use it if you have an HAE attack. This is especially important if you have swelling in your throat and you have trouble breathing.
- Before using Andembry (garadacimab), your healthcare professional will teach you how to give the injection. Be sure to read the Instructions for Use. Ask your care team if you have any questions.
- Inject Andembry (garadacimab) under the skin once a month. Choose an “Andembry day” that's easy for you to remember. It can be helpful to set reminders on your phone or calendar. Staying on schedule can help you stay protected from attacks.
- If you miss a dose of Andembry (garadacimab), inject the medication as soon as you remember. Then, continue with your monthly injections.
- You might have some redness, itching, or bruising where you inject Andembry (garadacimab). These reactions are usually mild and go away within a few days. If you need to, you can hold a cold pack where you injected the medication for a few minutes to help. Let your care team know if the reaction is severe, gets worse, or doesn't go away.
- Keep track of every Andembry (garadacimab) injection and any HAE symptoms in a diary. This helps your prescriber confirm it’s working for you and adjust your care plan if needed.
- Tell the care team that's ordering any blood tests or giving you surgery that you use Andembry (garadacimab). This medication can affect some blood clotting test results. Letting them know ahead of time can help prevent confusion and avoid repeat testing.
- If you’re pregnant, planning pregnancy, or breastfeeding: Let your care team know. There’s limited safety information for Andembry (garadacimab) in these situations. Because of this, your prescriber can discuss the risks and benefits and help you choose a safe option.
- How to store Andembry (garadacimab): Keep the medication refrigerated (36ºF to 46°F), but don’t let it freeze. Keep the medication in the original carton to protect it from light. Once it’s at room temperature for use, don’t put it back in the fridge.
How to inject Andembry (garadacimab) under the skin
- Wash your hands and gather your supplies.
- Before each Andembry (garadacimab) injection: Take the medication out of the fridge and let it warm up for 30 minutes on a flat surface. This can help make the injection more comfortable. Don’t microwave it, run it under hot water, or put it in direct sunlight because this can damage the medication. Also check that the medication is brownish-yellow to yellow and slightly shimmery to clear. Don't use it if it has particles in it or is discolored. Air bubbles are normal.
- Where to inject Andembry (garadacimab): Choose and clean your injection site with an alcohol pad. You can inject into your belly (at least 1 inch from the belly button) or thigh. A caregiver can also help inject it into the back of your upper arm. Pick a different spot for each injection. Avoid areas that are tender, bruised, red, or hard. Rotating sites and avoiding these areas help lower the chance of skin irritation.
- For the Andembry (garadacimab) autoinjector: Remove the cap and gently pinch your skin. Place the autoinjector flat against your skin at a 90º angle and press it down. Hold it in place until you hear 2 clicks, then keep holding for 5 more seconds. Don't tilt or rotate the autoinjector during the injection. The injection is done when the yellow plunger fills the viewing window and stops moving.
- For the Andembry (garadacimab) prefilled syringe: Hold the syringe in the middle and remove the needle cap. Gently pinch your skin and insert the needle at a 45º to 90° angle. Keep your skin pinched and push the plunger all the way down with your thumb. Then, slowly lift your thumb from the plunger before removing the syringe from your skin. The needle will automatically retract into the syringe.
- If needed, gently press on the injection site with gauze to stop any bleeding. Don't rub the area.
- After each Andembry (garadacimab) injection: Don’t reuse syringes or autoinjectors. Place your used autoinjector or syringe into an FDA‑cleared sharps container right away. Don't put them in the regular trash. This helps protect you and others from needle injuries.
Andembry (garadacimab) dosage
The average cost for 1 autoinjector of 1.2ml of 200mg/1.2ml of Andembry (garadacimab) is $60,477.40 with a free GoodRx coupon.
Autoinjector
Autoinjector| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 1.2ml of 200mg/1.2ml | 1 autoinjector | $60,477.40 | $60,477.40 |
Typical dosage for Andembry (garadacimab)
The typical loading dose is 400 mg (two 200 mg injections) under the skin on the first day.
After that, the typical maintenance dose is 200 mg injected under the skin once a month.
How much does Andembry (garadacimab) cost?
To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Andembry (brand)
$60,477.40
What are alternatives to Andembry (garadacimab)?
There are a number of medications that your doctor can prescribe in place of Andembry (garadacimab). Compare a few possible alternatives below.
News about Andembry (garadacimab)
