Aminocaproic acid (Amicar) is a medication that's used to control serious bleeding in certain situations, such as after surgical or medical complications. It's available as a tablet and a liquid for people who have trouble swallowing. Aminocaproic acid (Amicar) can also be given as an infusion through the veins by a trained healthcare provider. Most people don't experience much side effects with this medication, but some possible ones include swelling, headache, nausea, and rash.
Control bleeding in certain situations, such as in surgical or medical complications
Aminocaproic acid (Amicar) is an antihemorrhagic medication. It prevents the breakdown of certain clotting proteins in your body. This helps you bleed less by allowing your blood to clot.
Source: DailyMed
Side effects that you should report to your care team as soon as possible:
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
Taken by mouth
Available as an oral solution, for those who don't like taking tablets
Generally well-tolerated
Taken every hour (up to 8 hours) until bleeding stops
Can cause blood clots (rare)
Not well-studied for use during pregnancy or breastfeeding
Aminocaproic acid (Amicar) tablets come in two different strengths. Make sure you know which one you have and how many tablets to take to get the right dose.
You can take aminocaproic acid (Amicar) with or without food. If it upsets your stomach, try taking it with some food to help.
Let your provider know if you experience muscle weakness or tiredness while taking aminocaproic acid (Amicar). Though rare, this medication can muscle breakdown, which can be dangerous.
If you're taking aminocaproic acid (Amicar) oral solution, use the measuring device provided to you to get the exact dose. If you don't have one at home, ask your pharmacy or provider's office for one. Don't use kitchen or measuring spoons to measure your dose, since they might not be accurate.
Store aminocaproic acid (Amicar) tablets and oral solution at room temperature.
Aminocaproic acid (Amicar) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk Factors: Long-term use of aminocaproic acid (Amicar)
In rare cases, muscle wasting and weakness has been reported with aminocaproic acid (Amicar), especially with long-term use. Usually, this will go away once you stop taking the medication. Report any unexplained muscle pain or weakness to your provider. Muscle damage can have serious effects on your heart and kidneys. Your provider can order lab tests to see if this is happening in your body.
Tablets: The typical starting dose is 5 grams by mouth during the first hour of the bleeding event, followed by 1 gram every hour for 8 hours or until bleeding is controlled.
Oral solution (0.25 grams/mL): The typical starting dose is 5 grams by mouth during the first hour of the bleeding event, followed by 1.25 grams every hour for 8 hours or until bleeding is controlled.
Active blood clotting in the bloodstream
Cause of bleeding is unknown
Control bleeding in certain situations, such as in surgical or medical complications
Heavy menstrual bleeding that happens during several menstrual cycles in a row
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Carnegie Pharmaceuticals, LLC. (2023). AMINOCAPROIC ACID tablet [package insert].
Centers for Disease Control and Prevention. (2020). Spoons are for soup, milliliters are for medicine.
Fanashawe, M. P., et al. (2001). Two cases of fatal thrombosis after aminocaproic acid therapy and deep hypothermic circulatory arrest.
Hospira, Inc. (2022). AMINOCAPROIC ACID injection, solution [package insert]. DailyMed.
Kaseer, H., et al. (2022). Aminocaproic acid. StatPearls.
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