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Amikacin

Amikacin Side Effects

Robert Chad Hakim, PharmD, BCCCPAllison Gourley, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Allison Gourley, PharmD
Last reviewed on July 24, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Side effects aren't common. See Other Side Effects.

Less Common Side Effects

  • Rash
  • Fever
  • Headache
  • Tingling or "pins-and-needles" feeling
  • Tremor
  • Nausea
  • Vomiting
  • Joint pain
  • Low blood pressure
  • Low magnesium levels

Amikacin serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Side effects related to the nervous system: hearing problems, ringing in the ears, dizziness, numbness, tingling, muscle twitching, difficulty breathing, seizure
  • Serious kidney problems: tiredness, dry and itchy skin, low appetite, urinating less than usual, foamy or bloody urine, muscle cramps
  • C. difficile-related diarrhea: fever, stomach pain or cramps, foul-smelling diarrhea, frequent bowel movements (up to 15 times per day)
  • Serious allergic reaction: hives, rash, swelling of the lips or tongue, difficulty breathing

Source: DailyMed

The following Amikacin side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Incidence not known

Agitation

black, tarry stools

bloody or cloudy urine

bluish lips or skin

blurred vision

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chest pain

chills

coma

confusion

cough

decrease in the amount of urine

decreased urine output

depression

difficulty with breathing

difficulty with moving

dizziness

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

drowsiness

dry mouth

feeling of fullness in the ears

fever

headache

hearing loss

irritability

lethargy

loss of balance

loss or change in hearing

muscle pain or stiffness

muscle twitching

nausea

not breathing

pain in the joints

pain in the lower back or side

painful or difficult urination

pale skin

rapid weight gain

ringing or buzzing in the ears

seizures

shakiness in the legs, arms, hands, or feet

shortness of breath

sore throat

sores, ulcers, or white spots on the lips or in the mouth

stupor

sweating

swelling of the face, ankles, or hands

swollen glands

thirst

trembling or shaking of the hands or feet

trouble with hearing

troubled breathing with exertion

unusual bleeding or bruising

unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Skin rash

vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Robert Chad Hakim, PharmD, BCCCP, started his full-time career as a clinical pharmacist at UCLA Health in the general medicine, general cardiology, and ICU units after completing residency in 2016. He also was the preceptor for the general medicine rotation from 2017 to 2021, which was a required rotation for all pharmacy residents.
Allison Gourley, PharmD, is a kidney and pancreas transplant pharmacist at a teaching hospital in the San Francisco Bay Area. When she’s not educating patients about their immunosuppressants, she's actively involved in transplant research.

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