Commonly Used Brand Name(s)Ethyol
Therapeutic ClassificationsCytoprotective Agent
Amifostine is to be given only by or under the immediate supervision of your doctor.
A nurse or other trained health professional will give you this medicine in a hospital or cancer treatment center. This medicine is given through a needle placed in one of your veins.
Drink plenty of fluids during the 24 hours before receiving amifostine.
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of amifostine in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of amifostine in the elderly. However, elderly patients are more likely to have age-related heart, liver, or kidney disease, which may require an adjustment of dose in patients receiving amifostine.
|All Trimesters||C||Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical ProblemsTOP
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Congestive heart failure or
- Heart attack, history of, or
- Heart disease or
- Heart rhythm problems or
- Kidney disease or
- Stroke, history of, or
- Transient ischemic attacks (TIA or mini-stroke), history of—Use with caution. May cause side effects to become worse.
- Dehydration or
- Low blood pressure—Should not be used in patients with these conditions.
It is very important that your doctor check your progress at regular visits to allow for changes in your dose. Blood tests may be needed to check for any unwanted effects.
Low blood pressure (hypotension) may occur with this medicine. Check with your doctor right away if you have the following symptoms: blurred vision; confusion; severe dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly; sweating; or unusual tiredness or weakness.
Serious skin reactions can occur with this medicine. Check with your doctor right away if you have a rash on the lips or mouth; red skin lesions on the palms of the hands or soles of the feet; sores or ulcers on the skin; or fever or chills while you are receiving this medicine.
This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; trouble breathing; any swelling of your hands, face, or mouth; or chest pain after you receive this medicine.
This medicine may cause nausea and/or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects.