Advate
Newer factor VIII recombinant products, such as Advate, are infused through the veins to treat or prevent bleeds in people with a certain blood condition called hemophilia A. These products are different from the older first-generation factor VIII products, such as Hemofil M, because the newer products are made with technology that don't use human plasma. In addition, the newer factor VIII recombinant products can be used on a regular basis to prevent bleeds, whereas older factor VIII products are typically only used during surgery or procedures.
What is Advate (factor VIII)?
What is Advate (factor VIII) used for?
- To treat or prevent bleeds in people with hemophilia A
How Advate (factor VIII) works
Advate (factor VIII) is a clotting factor replacement for people who are missing special blood-clotting proteins called factor VIII (FVIII) due to hemophilia A. By replacing the missing clotting factor (FVIII, or antihemophilic factor) in people who naturally don't have it, bleeding episodes can be reduced or treated.
Drug facts
| Common Brands | Advate, Kogenate FS, Xyntha, Eloctate, Afstyla, Novoeight, Esperoct, Nuwiq, Altuviiio |
|---|---|
| Drug Class | Coagulation factor replacement |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
Side effects of Advate (factor VIII)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
The side effects below were reported by people who used Advate during clinical trials. If you're using a product besides Advate, the side effects you experience and your risk of side effects might be different.
- Fever (16%)
- Headache (13%)
- Cough (13%)
- Sore throat, runny nose, and other symptoms of the common cold (7-12%)
Less Common Side Effects
- Joint pain
- Vomiting
- Injury in the arms or legs
- Stuffy nose
- Diarrhea
- Pain, rash, or irritation at injection site
- Ear pain, trouble hearing, and other symptoms of an ear infection
Advate (factor VIII) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious allergic reaction (anaphylaxis): difficulty breathing, hives, itching, fast heartbeat, nausea, stomach pain, dizziness, lightheadedness, swelling in the face or tongue
The following Advate (factor VIII) side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Less common or rare
Changes in facial skin color
chills
fast or irregular breathing
puffiness or swelling of the eyelids or around the eyes
sensation of burning, warmth, heat, numbness, tightness, or tingling
tightness in the chest
trouble breathing
unusual tiredness or weakness
Incidence not known
Bluish color of the fingernails, lips, skin, palms, or nail beds
blurred vision
chest pain or discomfort
confusion
deep or fast breathing with dizziness
difficult or labored breathing
difficulty with swallowing
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
fast, pounding, or irregular heartbeat or pulse
noisy breathing
numbness of the feet, hands, and around the mouth
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
slow or irregular heartbeat
sweating
swelling of the face, throat, or tongue
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Headache
Less common
Burning, stinging, or swelling at the injection site
dizziness or lightheadedness
dry mouth or bad taste in the mouth
lack or loss of strength
nosebleed
redness of the face
vomiting
Rare
Change in taste
loss of taste
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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Pharmacist tips for Advate (factor VIII)
- If your provider thinks it's safe for you to use Advate (factor VIII) or any other factor VIII recombinant products at home, make sure that you get the training that you need before you start. Usually, your provider or your home infusion center staff can train and make sure you're comfortable doing your own infusions. If you have any questions, please talk with your provider.
- Before giving yourself a Advate (factor VIII) or other factor VIII recombinant product infusion, make sure to check your vial of medication to see that it's clear and doesn't have any specks floating in it. If it isn't clear and you notice specks, don't use that vial of medication.
- If you're giving yourself the infusion, only mix Advate (factor VIII) (or whichever factor VIII recombinant product you're using) when you're ready to give yourself the infusion. Once mixed, these products typically need to be used within 3 hours or less. Please look at your product's package insert to find out the time frame you have to inject your medication.
- Advate (factor VIII) infusions can cause your pulse rate to rise. Take your pulse before and regularly during your infusion. If your pulse goes up or if you experience any discomforts during the infusion, let your provider know because they might need to slow down your infusions. Also, ask your provider if there is anything that can be done before your next infusion to ease these side effects.
Risks and warnings for Advate (factor VIII)
Advate (factor VIII) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Serious allergic reaction
- Risk factors: Hamster or mouse protein allergy (except for Eloctate and Nuwiq)
Though rare, serious allergic reactions, including anaphylaxis, can happen with Advate (factor VIII) and other factor VIII products. Make sure to tell your provider all of your allergies before receiving treatment. If you experience rash, chest tightness, trouble breathing, or swelling in your lips, tongue, or throat after receiving Advate (factor VIII), get medical help right away.
Development of antibodies against FVIII
There's a chance that Advate (factor VIII) or other factor VIII products will stop working well for you even though it worked well in the beginning. This is because people who receive medications with FVIII can sometimes develop antibodies, also known as inhibitors, against FVIII. The inhibitors block FVIII, causing it to not work well. Let your provider know if bleeding becomes difficult to control even after receiving Advate (factor VIII). They might need to check whether or not you have antibodies and make changes to your treatment.
Advate (factor VIII) dosage
Kit| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| single dose of 250iu | 1 kit | $513.05 | $513.05 |
| single dose of 500iu | 2 kits | $2,025.05 | $1,012.53 |
| single dose of 1000iu | 4 kits | $8,073.05 | $2,018.26 |
| single dose of 1500iu | 24 kits | $67,296.39 | $2,804.02 |
| single dose of 2000iu | 2 kits | $8,073.05 | $4,036.53 |
| single dose of 3000iu | 2 kits | $8,932.94 | $4,466.47 |
Interactions between Advate (factor VIII) and other drugs
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
How much does Advate (factor VIII) cost?
$513.05
Advate (factor VIII) contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Advate (factor VIII) will not be safe for you to take.
- Allergy to hamster protein or any other inactive ingredients
