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Acetazolamide

Acetazolamide Side Effects

Allison Gourley, PharmDCydnee Ng, PharmD
Reviewed by Allison Gourley, PharmD, Cydnee Ng, PharmD
Last reviewed on July 19, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Tiredness
  • Headache
  • Nausea
  • Vomiting
  • Diarrhea

Less Common Side Effects

  • Numbness or tingling of the face, arms, or legs
  • Dizziness
  • Drowsiness
  • Blurred vision
  • Loss of appetite
  • Blurred vision
  • Changes in taste
  • Ringing in the ears (tinnitus)
  • Urinating more often

Acetazolamide serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Allergic reaction or severe skin reactions: hives, peeling or blistering skin, fever, trouble breathing, swelling of the face or lips
  • Electrolyte or acid-base imbalance: nausea, muscle cramps, tiredness, weakness, rapid breathing, or confusion

Source: DailyMed

The following Acetazolamide side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

Shortness of breath or trouble in breathing

Check with your doctor as soon as possible if any of the following side effects occur:

More common

Unusual tiredness or weakness

Less common

Blood in urine

difficult urination

mental depression

pain in lower back

pain or burning while urinating

sudden decrease in amount of urine

Rare

Bloody or black, tarry stools

clumsiness or unsteadiness

convulsions (seizures)

darkening of urine

fever

hives, itching of skin, skin rash, or sores

pale stools

ringing or buzzing in the ears

sore throat

trembling

unusual bruising or bleeding

yellow eyes or skin

Symptoms of too much potassium loss

Dryness of mouth

increased thirst

irregular heartbeats

mood or mental changes

muscle cramps or pain

nausea or vomiting

unusual tiredness or weakness

weak pulse

Also, check with your doctor if you have any changes in your vision (especially problems with seeing faraway objects) when you first begin taking this medicine.

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Diarrhea

general feeling of discomfort or illness

increase in frequency of urination or amount of urine (rare with methazolamide)

loss of appetite

metallic taste in mouth

nausea or vomiting

numbness, tingling, or burning in hands, fingers, feet, toes, mouth, lips, tongue, or anus

weight loss

Less common or rare

Constipation

dizziness or lightheadedness

drowsiness

feeling of choking or lump in the throat

headache

increased sensitivity of eyes to sunlight

loss of taste and smell

nervousness or irritability

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Allison Gourley, PharmD, is a kidney and pancreas transplant pharmacist at a teaching hospital in the San Francisco Bay Area. When she’s not educating patients about their immunosuppressants, she's actively involved in transplant research.
Cydnee Ng, PharmD
Reviewed by:
Cydnee Ng, PharmD
Cydnee Ng, PharmD, is a drug information pharmacist at GoodRx, where she lends her expertise to providing reader-friendly, accessible content about medications. She holds her pharmacist license in California.

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