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NANOPARTICLE ALBUMIN-BOUND PACLITAXEL (Na no PAHR ti kuhl al BYOO muhn-bound PAK li TAX el) is a chemotherapy drug. It targets fast dividing cells, like cancer cells, and causes these cells to die. This medicine is used to treat advanced breast cancer and advanced lung cancer. Compare microtubule inhibitors.
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Abraxane Side Effects

What should I watch for?

Your condition will be monitored carefully while you are receiving this medicine. You will need important blood work done while you are taking this medicine.

This medicine can cause serious allergic reactions. If you experience allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue, tell your doctor or health care professional right away.

In some cases, you may be given additional medicines to help with side effects. Follow all directions for their use.

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.

Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

Men are advised not to father a child while receiving this medicine.

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Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Black, tarry stools

bloating or swelling of the face, arms, hands, lower legs, or feet

blurred or double vision

chest pain

chills

cough

fever

loss of taste

lower back or side pain

painful or difficult urination

pale skin

rapid weight gain

sneezing

sore mouth, tongue, or throat

tightness in the chest

tingling of the hands or feet

troubled breathing with exertion

ulcers, sores, or white spots in the mouth

unusual bleeding or bruising

unusual weight gain or loss

unusual tiredness or weakness

Less common

Anxiety

bleeding

blood in the urine or stools

burning, tingling, numbness or pain in the hands, arms, feet, or legs

confusion

difficulty with swallowing

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

fast, pounding, slow, or irregular heartbeat or pulse

general feeling of discomfort or illness

inability to move the arms, legs, or facial muscles

inability to speak

pain in the chest, groin, or legs, especially the calves

pinpoint red spots on the skin

rapid, shallow breathing

sensation of pins and needles

severe, sudden headache

skin itching, rash, or redness

slurred or slow speech

stabbing pain

sudden loss of coordination

sudden, severe weakness or numbness in the arms or legs

sudden, unexplained shortness of breath

sweating

swelling of the face, throat, or tongue

thickening of bronchial secretions

trouble thinking or walking

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Cracked lips

decreased appetite

diarrhea

difficulty with moving

headache

lack or loss of strength

loss of hair

muscle pain or stiffness

nausea

pain in the joints

swelling

vomiting

Less common

Bleeding, blistering, burning, coldness, discoloration of the skin, a feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

Rare

Nail changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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