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ZosynPiperacillin / Tazobactam
PIPERACILLIN; TAZOBACTAM is a penicillin antibiotic. It is used to treat certain kinds of bacterial infections. It will not work for colds, flu, or other viral infections. Compare penicillin antibiotic / beta lactamase inhibitor combinations.
Prescription Settings
21 vials
piperacillin / tazobactam(generic)
21 vials

Zosyn Side Effects

What should I watch for?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Your doctor will monitor your condition and blood work as needed.

Do not treat diarrhea with over the counter products. Contact your doctor if you have diarrhea that lasts more than 2 days or if it is severe and watery.

This medicine can interfere with some urine glucose tests. If you use such tests, talk with your health care professional.


Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common


Less common

Bladder pain

bloating or swelling of the face, arms, hands, lower legs, or feet

blurred vision

burning upper abdominal or stomach pain

changes in urination

chest pain


dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

fever or sweating


inflammation or swelling at the injection site

lower back or side pain

nausea or vomiting

pain, tenderness, or swelling of the foot or leg

pain, warmth, or burning in the fingers, toes, and legs

problems with vision or hearing

skin rash

slow or fast heartbeat

troubled breathing


Abdominal or stomach cramps, pain, or tenderness


bone pain



cold sweats


deep or fast breathing with dizziness


diarrhea, watery and severe, which may also be bloody


dry mouth



itching of the vagina or genital area


muscle pain or cramps

muscle stiffness or twitching


numbness or tingling in the hands, feet, or lips

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

sore throat

sores, ulcers, or white spots on the lips, tongue, or inside the mouth

swollen glands

temporary blindness

thick, white vaginal discharge with no odor or with a mild odor

total body jerking

unexplained weight loss

unusual bleeding or bruising

Incidence not known

Back or leg pain

blistering, peeling, or loosening of the skin

high fever

joint or muscle pain

red skin lesions, often with a purple center

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Difficulty having a bowel movement (stool)

trouble sleeping

Less common

Acid or sour stomach

cracks in the skin at the corners of the mouth


irritation and redness of the skin

runny nose


stuffy nose

white patches in the mouth or on the tongue


Body aches or pain

burning feeling in the chest or stomach

change in taste or bad unusual or unpleasant (after) taste

feeling of constant movement of self or surroundings

sensation of spinning

severe sleepiness

tenderness in stomach area

vision changes

voice changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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