What should I watch for?
Do not take other medicines that contain aspirin, ibuprofen, or naproxen with this medicine. Side effects such as stomach upset, nausea, or ulcers may be more likely to occur. Many medicines available without a prescription should not be taken with this medicine.
This medicine can cause ulcers and bleeding in the stomach and intestines at any time during treatment. This can happen with no warning and may cause death. There is increased risk with taking this medicine for a long time. Smoking, drinking alcohol, older age, and poor health can also increase risks. Call your doctor right away if you have stomach pain or blood in your vomit or stool.
Side Effects to watch for
Side effects that you should report to your doctor or health care professional as soon as possible:
- allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
- breathing problems
- chest pain or chest tightness
- feeling faint or lightheaded
- redness, blistering, peeling or loosening of the skin, including inside the mouth
- signs and symptoms of kidney injury like trouble passing urine or change in the amount of urine
- signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin
- signs and symptoms of low magnesium like muscle cramps, pain, or weakness; tremors; seizures; or fast, irregular heartbeat
- signs and symptoms of low vitamin B-12 levels like shortness of breath; lightheaded; irregular heartbeat; muscle weakness; pale skin; feeling tired; changes in emotions or mood; and tingling or numbness
- signs of bleeding such as bloody or black, tarry stools; red or dark-brown urine; spitting up blood or brown material that looks like coffee grounds; red spots on the skin; unusual bruising of bleeding from the eye, gums, or nose
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
What may interact with this drug?
Do not take this medicine with any of the following medications:
- certain antiretrovirals for HIV or AIDS like atazanavir, nelfinavir, and rilpivirine
- St. John's Wort
This medicine may also interact with the following medications:
- certain medicines for blood pressure called ACE inhibitors and beta blockers
- certain medicines for diabetes
- certain medicines that treat or prevent blood clots like heparin and warfarin
- certain other antiretrovirals for HIV or AIDS
- high dose methotrexate
- NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
- valproic acid