Winrevair Dosages for Pulmonary Arterial Hypertension: Your GoodRx Guide

Winrevair (sotatercept-csrk) is a prescription-only medication that was approved in 2024 to treat pulmonary arterial hypertension (PAH) in adults. It’s the first approved medication in a new class called activin signaling inhibitors. Winrevair may be added onto your other PAH medications to improve your ability to exercise. It can also lower the risk of events associated with PAH getting worse.

Winrevair comes as an injection that you may be able to administer at home after being properly trained. How much you’ll inject is determined by your body weight. Below, we break down typical Winrevair dosages and what to expect when you first start treatment.

What to expect when starting treatment with Winrevair

When you start treatment with Winrevair, you’ll be required to take blood tests to ensure it’s safe for you to receive the injections. Expect to have these tests done before at least the first five doses and periodically during treatment. The blood tests will check your levels of hemoglobin (a protein in red blood cells) and platelets (blood clotting cells).

If your platelets are below a certain level before your first dose, you’ll have to wait to start receiving injections. And if they drop below a certain level during treatment, your doses may be delayed until your platelets are in a safe range. This is also the case if your hemoglobin, which can increase during treatment, is too high. These steps are taken to ensure that it’s safe for you to receive Winrevair. 

Winrevair comes as a subcutaneous (under the skin) injection that’s initially administered by a healthcare professional. After proper training, you (or a caregiver) may be able to administer Winrevair at home.

Winrevair comes in single-dose vials and needs to be combined with sterile water before administration. When you fill your prescription, you’ll receive the medication in an injection kit. Each kit contains either one or two vials and one or two syringes filled with sterile water. Your healthcare team will show you how to prepare your dose and administer it correctly.

What’s the typical Winrevair dosage?

Typical Winrevair dosages for PAH are based on body weight. Your prescriber will calculate your dosage for you and tell you how much to inject. You’ll likely inject doses every 3 weeks (or as otherwise directed by your prescriber).

The usual starting Winrevair dosage is 0.3 mg per kilogram of body weight, injected every 3 weeks. Your prescriber will determine when, and if, your dosage can be increased. The recommended target dosage is 0.7 mg per kilogram of body weight, injected every 3 weeks.

As described above, your doses may need to be delayed based on your blood test results. If this happens, your prescriber will likely recheck your levels at 3-week intervals until they’re in a safe range. If you’ve missed at least 3 doses (9 weeks), they may have you go back to the starting dosage and work your way up.

EXPERT PICKS: WHAT TO READ NEXT

• Guide to pulmonary arterial hypertension (PAH): Experts break down the different symptoms, causes, and treatments of PAH.

• How they compare: There are many medications that help manage PAH. Learn about the different types of PAH medications and how they stack up.

• Portable oxygen therapy: Oxygen therapy can help with PAH symptoms such as shortness of breath. Learn more about portable oxygen options that allow you to use oxygen outside the home.

What happens if you miss a dose of Winrevair?

If you miss a dose of Winrevair, administer it as soon as possible. If 3 days or more have passed since the date the dose was scheduled for, contact your prescriber. Your dosage schedule may need to be adjusted to maintain the recommended 3-week interval.

If you inject Winrevair at home and are regularly missing your scheduled doses, there are tools available to help. For example, you can set up a calendar alert or use a medication reminder app on your smartphone to stay on track. 

If you’re receiving Winrevair in a medical office, be sure to go to all of your scheduled appointments. And contact the office right away if you’re unable to make an appointment.

What should you do if you take too much Winrevair?

After you’ve added sterile water to a Winrevair vial, double check that you’re drawing up the correct amount of medication for your dose. Otherwise, you might accidentally inject too much (or too little) Winrevair. 

If you think you may have injected too much Winrevair, speak with your healthcare team right away. If your team is unavailable, another option is to call Poison Control at 1-800-222-1222. You can call Poison Control for free, and someone is available 24 hours a day, 7 days a week. 

High Winrevair dosages have been associated with increased hemoglobin levels, resulting in high blood pressure. If you’ve injected too much, your healthcare team may want to closely monitor you for these effects.

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Written by:

Brian Leonard, PharmD, BCACP, BCGP

Brian Leonard earned his doctorate in pharmacy from the University of Florida College of Pharmacy and is board certified in Ambulatory Care and Geriatric Pharmacy.

Edited by:

Alyssa Billingsley, PharmD

Alyssa Billingsley, PharmD, is the director of pharmacy content for GoodRx. She has over a decade of experience as a pharmacist and has worked in clinical, academic, and administrative roles.

Reviewed by:

Austin Ulrich, PharmD, BCACP

Austin Ulrich, PharmD, BCACP, is a board-certified ambulatory care clinical pharmacist. In his early career, he provided direct patient care in a variety of settings, including hospital and community pharmacies, and in a primary care clinic as a clinical pharmacist.

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