Vivimusta (bendamustine) is a type of chemotherapy medication called an alkylating agent. It’s approved to treat some blood cancers like chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL). This medication is given as an infusion through a vein at a medical center or clinic. It’s given over about 20 minutes on the first 2 days of each treatment cycle. Side effects include nausea, tiredness, low blood cell counts, and a risk of infection.
Vivimusta (bendamustine) is a type of traditional chemotherapy known as an alkylating agent. It works by damaging fast-growing cells in the body, like cancer cells. The medication damages the cells’ DNA, which usually causes them to die. This helps fight cancer.
Vivimusta (bendamustine) is given as an infusion through a vein. This is also called an intravenous or IV infusion. Your nurse will probably use an IV access device, like a port, to give the medication. This helps keep the medication from leaking into nearby tissues and causing irritation. Each infusion usually takes around 20 minutes.
Vivimusta (bendamustine) is given on days 1 and 2 of each treatment cycle. If you have CLL, each cycle starts every 4 weeks and you can do up to 6 cycles. If you have NHL, each cycle starts every 3 weeks and you can do up to 8 cycles. Ask your oncologist about your personal treatment plan.
To get Vivimusta (bendamustine), you’ll need to go to a cancer center or infusion clinic. You can’t pick up this medication from a regular pharmacy. This is because a nurse or other trained healthcare professional will give you the infusion safely through an IV. They will also watch you and help if you have side effects like nausea or an infusion reaction. Talk to your oncology care team about setting up your Vivimusta (bendamustine) appointments.
Common side effects of Vivimusta (bendamustine) include nausea, vomiting, and feeling tired. It’s also common to have low blood cell counts, which can make it easier for you to get sick or bruise. To help with nausea, your oncologist can give you antiemetic medications. Be sure to drink plenty of fluids to stay hydrated and eat small meals throughout the day to help calm your stomach. Also wash your hands often and avoid large crowds to prevent getting sick. Call your care team right away if you get a fever because it could be the only sign that you’re sick. If you notice any side effects that are too hard for you to handle, tell your care team so they can help you. Ask your care team about other side effects to look out for too.
Vivimusta (bendamustine) doesn’t usually cause hair loss. If you notice any hair thinning or shedding, let your oncology care team know. They can talk to you about possible causes and help you manage hair loss.
Skin rash isn’t common with Vivimusta (bendamustine), but it’s possible. In rare cases, it can cause very serious skin reactions that can be life threatening. The risk might be higher if you take allopurinol (Zyloprim) at the same time as Vivimusta (bendamustine). Get medical help right away if you notice a rash, painful blisters, sores on the skin, peeling skin, or fever during treatment. These can be signs of a serious skin reaction that needs urgent care.
Yes. If you can become pregnant, use an effective form of birth control while taking Vivimusta (bendamustine). Keep using birth control for 6 months after your last infusion. If you’re a man who can get someone pregnant, also use birth control, like condoms, during treatment and for 3 months after your last dose. This is important because Vivimusta (bendamustine) might harm an unborn baby. Tell your oncologist right away if you or your partner becomes pregnant during treatment.
Vivimusta and Bendeka are brand-name versions of bendamustine. They treat the same blood cancers and are given as an infusion through the vein. The main differences are their formulations and how long each infusion takes. Each Vivimusta infusion is given over about 20 minutes. But each Bendeka infusion takes about 10 minutes. Talk to your oncologist to see which one is right for you.
Your oncologist will find the right dose for you. It’s based on your body size or body surface area (BSA), which is calculated in units of m². To figure this out, your oncologist will use your height and weight to calculate how much medication you need.
CLL: The typical dose is 100 mg/m² given as an infusion through the vein (an intravenous or IV infusion). It’s given over 20 minutes on days 1 and 2 of each 28-day cycle for up to 6 cycles.
B-cell NHL: The typical dose is 120 mg/m² given as an IV infusion. It’s given over 20 minutes on days 1 and 2 of a 21-day cycle for up to 8 cycles.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Vivimusta (bendamustine) will not be safe for you to take.