Typhim Vi
Typhim Vi is an inactivated vaccine that helps protect people ages 2 and older from typhoid fever, a life-threatening bacterial infection. The vaccine isn't routine for everyone — it's only recommended for certain people at high risk of coming into contact with the typhoid bacteria. It's given as a single injection into the muscle to provide protection for 2 years. The most common side effects are pain and tenderness at the injection site.
What is Typhim Vi?
What is Typhim Vi used for?
Prevention of typhoid fever in adults and children 2 years or older
How Typhim Vi works
Typhim Vi is an inactivated vaccine that protects you from typhoid fever. It works by helping your immune system make antibodies that can recognize and fight off the typhoid bacteria if it ever enters your body.
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What are the side effects of Typhim Vi?
Common Side Effects
- Tenderness at injection site (up to 98%)
- Pain at injection site (up to 41%)
- Feeling unwell (up to 24%)
- Headache (up to 20%)
- Hardening of skin at injection site (up to 15%)
- Nausea (up to 8%)
- Muscle pain (up to 7%)
- Redness at injection site (up to 5%)
Other Side Effects
- Fever
- Vomiting
- Diarrhea
Serious Side Effects
- Serious allergic reactions: hives, rash, shaking, itching, nausea, flushing, dizziness, shortness of breath, chest pain
Source: DailyMed
The following side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
More common
general feeling of discomfort or illness
pain, redness, swelling, tenderness or a lump at the place of injection
unusual tiredness or weakness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Pros and cons of Typhim Vi
Pros
Only 1 dose needed before potential exposure
Can be given to children as young as 2 years old
No significant interactions with other medications
Cons
Only available as an injection into the muscle
Must be given by a healthcare professional at a provider’s office, clinic, or pharmacy
Only provides protection for up to 2 years
Pharmacist tips for Typhim Vi
If you travel often to places where typhoid fever is a risk, you should get another dose of Typhim Vi every 2 years to keep you protected.
Even after getting Typhim Vi, practice safe eating and drinking habits. This vaccine helps prevent typhoid fever, but isn't 100% effective. Get medical help right away if you develop symptoms of typhoid fever like fever, weakness, stomach pain, and loss of appetite.
Typhim Vi helps to prevent typhoid fever but doesn't treat it. If you get typhoid fever, you'll likely be prescribed antibiotics for treatment. Take them exactly as directed and finish the full course, even if you feel better.
It's not known if Typhim Vi harms unborn babies when given during pregnancy. It should only be used if absolutely necessary. Discuss with your OB-GYN provider about the risks and benefits before getting the vaccine.
If you experience a severe reaction to Typhim Vi, you or your care team can report it to the vaccine adverse event reporting system (VAERS) online or by calling 1-800-822-7967.
Frequently asked questions about Typhim Vi
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What are the risks and warnings for Typhim Vi?
Typhim Vi can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Avoid contaminated food and water
Just like all vaccines, receiving Typhim Vi doesn't guarantee that you won't get typhoid fever. For the best protection, you should get a typhoid vaccine, such as Typhim Vi, and take precautions to avoid contaminated food and drinks. Some examples include avoiding raw foods, street food, bushmeat (wild game not commonly eaten in the U.S.), tap water, fountain drinks, ice, and freshly squeezed juice.
Severe allergic reactions
As with any vaccine, there's a small chance that you could have a severe allergic reaction to Typhim Vi. Your prescriber might ask you to stay at the pharmacy or clinic for a short time after getting the vaccine to make sure you can get proper care if needed. Sometimes, these reactions can happen after you leave. Get medical help right away if you have symptoms of a severe allergic reaction, such as swelling of the face, closing of the throat, trouble breathing, hives, rash, dizziness, shaking, nausea, or chest pain.
Fainting
Some people have fainted after receiving Typhim Vi, and it can happen with all vaccines. While fainting isn't usually serious, falling or other accidents can cause injuries. To keep you safe, your prescriber or pharmacist should have procedures in place to prevent falls and handle fainting reactions if they happen.
Weakened immune system might affect vaccine response
Risk factors: Medical conditions that weaken the immune system | Taking medications that lower your immune system
Typhim Vi might not work as well if you have a weakened immune system, which could put you at a higher risk of typhoid fever, even after getting vaccinated. If you have certain medical conditions like HIV or cancer, take medications that weaken your immune system (e.g., high-dose corticosteroids, transplant medications, cancer treatments), or are receiving or have undergone radiation therapy, talk to your healthcare professional before getting Typhim Vi.
Typhim Vi dosage forms
Typical dosing for Typhim Vi
The dose is 1 injection (0.5 mL) into the muscle at least 2 weeks before potential exposure to the bacteria.
Adults: The vaccine is typically injected into the shoulder muscle.
Children: The vaccine is typically injected into the shoulder or outer thigh muscle.
Interactions between Typhim Vi and other drugs
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
How much does Typhim Vi cost?
What are alternatives to Typhim Vi?
Prevention of typhoid fever in adults and children 2 years or older
Prevention of typhoid fever in people ages 6 years or older
Typhim Vi images
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References
Best studies we foundCenters for Disease Control and Prevention. (2019). Typhoid vaccine VIS.
Centers for Disease Control and Prevention. (2023). Food and drink considerations when traveling.
Centers for Disease Control and Prevention. (2024). About typhoid fever and paratyphoid fever.
Centers for Disease Control and Prevention. (2024). Fainting and vaccines.
Centers for Disease Control and Prevention. (2024). Preventing typhoid fever and paratyphoid fever.
Centers for Disease Control and Prevention. (2024). Symptoms of typhoid fever and paratyphoid fever.
Cox, J. E., et al. (2006). Egg-based vaccines. Pediatrics in Review.
Hughes, M., et al. (2024). Typhoid & paratyphoid fever. Centers for Disease Control and Prevention.
Sanofi Pasteur Inc. (2023). Typhim Vi- salmonella typhi ty2 vi polysaccaride antigen injection, solution [package insert]. DailyMed.
World Health Organization. (2020). How do vaccines work?
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