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Tibsovo Medicare coverage

Used for Leukemia

Tibsovo Coupon - Tibsovo 250mg tablet

Tibsovo (ivosidenib) is a targeted therapy for cancer called an IDH1 inhibitor. It's used to treat adults with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), or bile duct cancer (cholangiocarcinoma). This medication is FDA approved only for people who have the IDH1 mutation in their cancer. Tibsovo (ivosidenib) is a tablet that you take by mouth once a day. But it can cause side effects like nausea, diarrhea, and tiredness. It can also cause a serious reaction called differentiation syndrome in people with AML or MDS.

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Annual Notice of Change (ANOC):

The Medicare Annual Notice of Change (ANOC) is a letter for people enrolled in Medicare Advantage plans and anyone with Medicare Part D prescription coverage. People with Medicare Advantage or original Medicare (Part A and/or Part B) can have Part D plans. The ANOC informs enrollees about any changes to their benefits for the coming coverage year. By law, Medicare Advantage and Part D plans must send the ANOC to enrollees by September 30 — which is before the annual Medicare open enrollment period of October 15 to December 7. Even if you have the same plan, your benefits could change year to year.

Premium:

A premium is the cost of having a health insurance plan and is usually paid monthly. Medicare enrollees may pay several premiums. Most people don’t pay anything for Part A hospital insurance, but some people do depending on how long they worked and paid taxes. For outpatient and preventive coverage, the Part B standard premium is $185 a month in 2025, but people with higher incomes pay more. Your premium for Medicare Advantage plans will vary, but even so-called “zero premium” plans require you to pay your Part B premium. Part D premiums range in price, but the average is about $47 a month in 2025. If you have original Medicare and a Medigap supplement plan, you have an additional premium for that coverage.

Deductible:

A deductible is the amount you pay out of pocket before your Medicare plan begins cost-sharing. In 2025, the Part A deductible is $1,676 per benefit period. The Part B deductible is $257 for the year, but you can access certain preventive care — including some vaccines — without meeting your deductible. Medicare Advantage deductibles vary and your Part D deductible can’t exceed $590 in 2025.

Out-of-pocket limit:

Original Medicare has no annual out-of-pocket maximum. Medicare Advantage plans have out-of-pocket limits. In 2025, they are $9,350 for in-network covered services and $14,000 for in-network and out-of-network covered services combined.

Medicare Prescription Payment Plan:

Starting January 1, 2025, anyone with Part D coverage had the option to use the Medicare Prescription Payment Plan for their out-of-pocket medication costs instead of paying upfront at the pharmacy. This plan doesn’t provide savings, but allows you to spread prescription costs — including your deductible — over the year. Making payments can be particularly helpful for people who may skip or delay picking up prescriptions because of high costs early in the year. Also in 2025, the Part D out-of-pocket limit dropped to $2,000.

Initial coverage phase:

After a Medicare enrollee meets the Part D deductible (if the plan has one), the health insurance begins cost sharing. The initial coverage phase means you pay coinsurance or a copay for covered prescriptions.

Catastrophic phase:

When you reach the $2,000 out-of-pocket maximum, your Part D plan pays for 100% of covered medications for the rest of the year.

Medication ready
How to save on drugs with Medicare

Medicare Part D is the part of Medicare that helps cover prescription medications, including both brand name and generic. It also includes coverage for certain vaccines that aren’t covered by Part B, as well as some medical supplies.

Even with Medicare Part D coverage, you may still have out-of-pocket costs such as premiums, deductibles, copayments, and coinsurance. As of 2025, Medicare Part D plans include a $2,000 annual out-of-pocket cap. Once you reach this limit, your plan covers the full cost of your covered medications for the rest of the year.

Still, there are several ways to reduce your prescription medication cost. From GoodRx coupons to patient assistance programs, here are ways you can save money on the medications you need.

1. See if you qualify for Medicare’s Extra Help program

The Medicare Extra Help/Low-Income Subsidy program is a federally funded program for people covered under a Medicare Part D plan. It helps reduce enrollees’ out-of-pocket costs by limiting their deductibles and copays. To qualify, your income and assets fall below a certain limit.

If you’re eligible, you may receive:

  • No monthly premiums for Medicare Part D

  • No Medicare Part D deductible

  • Low copays for prescription medications

2. Use GoodRx coupons

You can’t combine GoodRx coupons with Medicare, but you can choose to use a coupon instead of your insurance if it results in a lower price.

Here’s how to download a GoodRx coupon:

  1. Go to the GoodRx website, or download the GoodRx app on your phone.

  2. Search for your prescription medication.

  3. Enter your prescribed dose and quantity, then set your location.

  4. Compare prices across different pharmacies in your area.

  5. Click “Find the lowest prices” or press “Enter.”

  6. You can have the coupon sent by text or email, or print it out.

  7. To apply the discount, show the coupon at the pharmacy when you fill your prescription. Ideally, this is done at drop-off before the prescription is filled.

3. Consider the Medicare Prescription Payment Plan

The Medicare Prescription Payment Plan is a new program that can help make paying for medications more manageable. It’s open to anyone with a standalone Part D plan or those with Medicare Advantage plans that offer prescription medication coverage.

There is no cost to participate in the Medicare Prescription Payment Plan and participation is voluntary. Instead of paying for the total cost of your medications up front at the pharmacy, the payment plan allows you to spread the cost into smaller payments during the year. If you join, you will continue to pay your premium every month as well as an additional monthly amount on your payment plan. It’s a good idea to review how the Medicare Prescription Payment Plan works to determine if it’s right for you.

4. Compare Part D plans during open enrollment

Medicare open enrollment, which takes place every year from October 15 to December 7, is your chance to switch plans if another option offers better prescription medication coverage or lower costs. Plan costs and coverage details can change each year, so it’s important to review your options.

Here are some steps to help you compare plans:

  1. Make a list of all your medications and what dosages you take.

  2. Enter the names of your prescription medications to see which plans offer the best coverage.

  3. Look at premiums, deductibles, and medication costs for each plan. Plans usually change their formularies, premiums, and copays annually.

  4. Check if your preferred pharmacy is in each plan's network.

5. Get a 90-day supply

Opting for a 90-day supply instead of a monthly refill of your medication might help reduce your long-term out-of-pocket costs. Many insurance plans offer lower copays or bulk pricing for 3-month prescriptions.

If your medication is covered under your plan, see if your insurer’s mail-order or specialty pharmacy provides savings on a 90-day supply. If they do, ask your prescriber to write a prescription for a 90-day quantity to take advantage of these potential savings.

6. Ask about the generic version of your medication

Some medications have a generic version, and they generally cost less than the brand-name prescriptions. Generic medications are just as safe and effective as brand-name medications, so it’s an option worth considering to reduce your cost. Ask your prescriber about switching to a generic version of your medication to save money.

7. Consider lower-cost alternative medications

There may be other medications that help manage your condition, and they may cost less. If your medication is costly or not covered by your insurance, talk to your prescriber about lower-cost alternatives that might be a good option for you. Alternatives might have better insurance coverage or lower costs.

8. Learn more about patient assistance programs

Patient assistance programs (PAPs) offer free or low-cost medications to uninsured and low-income consumers. These programs, which primarily offer savings on brand-name medications, are usually run by private pharmaceutical companies or nonprofit organizations. You must meet certain qualifications and complete paperwork to receive savings from PAPs. However, some PAPs exclude Medicare recipients, so it’s important to review the program’s rules and requirements carefully.

9. Check state-funded resources

Depending on where you live, your state may offer programs to help you navigate prescription medication costs. A good place to start is your local Department of Aging. This U.S. Department of Health and Human Services office can help you find the best Medicare plan for the coverage you need.

Some states even have their own cost-saving programs for older adults. For example, Pennsylvania runs PACE and PACENET. These programs help eligible residents get prescription medications at reduced costs.

Alternatively, you can find out if your state has a State Pharmaceutical Assistance Program by using Medicare’s search tool. These programs are state-run and help qualifying residents pay for prescription medications.

10. Use a health savings account to pay for prescription medications

Although you can’t contribute to a health savings account (HSA) after enrolling in Medicare, you can still use any remaining funds in your account to pay for qualified medical expenses. An HSA allows you to use tax-free dollars to pay for eligible prescription medications. The money in your account does not expire so you can use your funds at any time to reduce your out-of-pocket medication costs.

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Frequently asked questions about Tibsovo

No, Tibsovo isn’t a traditional chemotherapy medication. Traditional chemotherapy works by attacking cells in the body that are growing quickly, such as cancer cells. Tibsovo works in a more specific way, so it’s considered a type of targeted therapy. Tibsovo is an IDH1 inhibitor. It finds and attaches to the mutated version of the IDH1 protein in certain cancer cells. This stops these cancer cells from growing and spreading as well.

No. Tibsovo works very specifically by blocking the IDH1 protein. So, the medication is recommended for use only in people whose cancer has an IDH1 mutation. Talk to your oncologist about other treatment options that are more appropriate for you (like chemotherapy) if you’ve been diagnosed with AML, MDS, or bile duct cancer without an IDH1 mutation.

Tibsovo can be used off-label for certain brain cancers that have an IDH1 mutation. The National Comprehensive Cancer Network (NCCN) lists Tibsovo as a treatment option for certain IDH1-mutated gliomas after other therapies (e.g., surgery). The NCCN recommendations are based on studies showing that some people with these types of brain cancers had clinical benefits with Tibsovo even though the medication isn’t FDA approved for this purpose. Talk with your oncologist about whether Tibsovo can be used for your specific cancer.

Yes, Tibsovo can cause joint pain. In studies, 36% of people with relapsed or refractory AML who took Tibsovo reported joint pain. This included back pain, neck pain, or stiffness. During treatment, it might help to keep a journal of any instances of pain, the type of pain, and anything that makes it better or worse. Then, you can talk with your oncologist about options for pain management.

Some people who take Tibsovo can have abnormal heart rhythm. This abnormal heart rhythm can be caused by a delay in the time it takes the heart to recharge after it beats (called QT prolongation). Before you start Tibsovo and also during treatment, your oncologist will check your risk for QT prolongation and abnormal heart rhythm through an electrocardiogram (EKG). Get medical help immediately if you have an irregular heartbeat, have chest pain, feel dizzy, or pass out. These can be signs of an abnormal heart rhythm.

Avoid taking other medications that can cause abnormal heart rhythm with Tibsovo. These medications include amiodarone (Pacerone) and levofloxacin, among others. Tibsovo can affect your heart rhythm and taking other medications that have a similar effect on the heart can raise your risk even more. In addition, don’t take certain seizure medications like carbamazepine (Tegretol) with Tibsovo because the cancer medication might work less well if they’re taken together. Also avoid other medications, like clarithromycin or diltiazem (Cardizem). They might put you at higher risk for side effects from the cancer medication. Share an up-to-date list of your medications with your prescribers and pharmacists. They can check for any dangerous drug interactions and give recommendations on any treatment changes to keep you safe.

It’s best not to drink alcohol while you’re taking Tibsovo. There aren’t any known interactions between Tibsovo and alcohol. But drinking alcohol could make side effects like tiredness more intense. Also, regularly drinking large amounts of alcohol could harm your liver. This could make it harder for your body to get rid of Tibsovo from your system, leading to a higher risk of side effects. Speak with your oncologist about your drinking habits.

How long you take Tibsovo depends on several things. In general, your oncologist will recommend that you keep taking Tibsovo as long as it’s working for you and as long as you don’t have bothersome or serious side effects from it. Your oncologist will check results from your blood tests, biopsies, and scans to see how well the medication is working to treat your cancer. For people with AML or MDS, it can sometimes take at least 6 months of treatment to see a noticeable improvement in your test results. Your oncology team will also ask about side effects during your regular visits. Tell your care team if you have severe side effects such as diarrhea, nausea, or weakness. Don’t stop taking Tibsovo without first discussing with your oncologist.