IDH1 inhibitors are used to treat acute myeloid leukemia (AML), cholangiocarcinoma (bile duct cancer), and myelodysplastic syndromes. These medications work by targeting and inhibiting mutated isocitrate dehydrogenase-1 (IDH1) enzymes, which helps to slow the growth of cancer cells. IDH1 inhibitors are available in oral form, making them convenient to take. Examples include Tibsovo (ivosidenib) and Rezlidhia (olutasidenib).