Commonly Used Brand Name(s)Thyrogen, Thytropar
Therapeutic ClassificationsDiagnostic Agent, Thyroid Function
Pharmacologic ClassificationsThyrotropin
QUICK LINKS
- Overview
- Proper Use
- Before Using
- Allergies
- Pediatric
- Geriatric
- Pregnancy
- Breast Feeding
- Drug Interactions
- Other Interactions
- Other Medical Problems
- Precautions
OverviewTOP
Thyrotropin alfa injection is a form of human thyroid stimulating hormone (TSH). It is used with or without radioactive iodine imaging to test the presence of thyroglobulin (Tg) in patients with thyroid cancer.
Thyrotropin alfa is also used with radioactive iodine to remove any remaining diseased thyroid tissue in patients with thyroid cancer who have had most or all of their thyroid gland removed.
This medicine is to be given only by or under the immediate supervision of your doctor.
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Proper UseTOP
Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
A nurse or other trained health professional will give you this medicine in a hospital or cancer treatment center. This medicine is given as a shot into a muscle of the buttocks.
For your doctor to properly treat your medical condition, you must receive 2 doses of this medicine. After the last dose, your doctor may want to perform certain tests that are very important.
Your doctor may have special instructions for you to get ready for your treatment. If you have not received such instructions or you do not understand them, check with your doctor ahead of time.
Before UsingTOP
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
AllergiesTOP
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
PediatricTOP
Appropriate studies have not been performed on the relationship of age to the effects of thyrotropin alfa injection in children younger than 16 years of age. Safety and efficacy have not been established.
GeriatricTOP
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of thyrotropin alfa injection in the elderly. However, elderly patients are more likely to have arrhythmia or heart problems which may require caution in patients receiving this medicine.
PregnancyTOP
| Pregnancy Category | Explanation | |
|---|---|---|
| All Trimesters | C | Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. |
Breast FeedingTOP
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug InteractionsTOP
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Other InteractionsTOP
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical ProblemsTOP
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Allergy to bovine thyroid stimulating hormone, or history of or
- Heart disease, history of or
- Metastatic cancer (cancer that has already spread to different parts of the body) or
- Nervous system disorder (e.g., hemiparesis, hemiplegia) or
- Significant residual thyroid tissue or
- Stroke, history of—Use with caution. May increase the risk for serious side effects.
- Kidney disease, end stage or
- Patients undergoing dialysis—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
PrecautionsTOP
It is very important that your doctor check you closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood tests may be needed to check for unwanted effects.
Call your doctor right away if you have an inability to move the legs or arms, or paralysis of one side of the body after receiving this medicine.
Tell your doctor right away if you have sudden, rapid, and painful enlargement of thyroid tumors, noisy breathing, shortness of breath, or voice changes. Your doctor may want you to receive glucocorticoids (steroids) before receiving this medicine.
