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Thymoglobulin

antithymocute globulin
Used for Organ Transplant

Thymoglobulin is an intravenous (IV) medication that you might receive once you get a kidney transplant. It belongs to the drug class called depleting polyclonal antibodies. This medication lowers the activity of your immune system to prevent it from rejecting your new organ. It's typically used in addition to other immunosuppressants. Thymoglobulin can cause many infusion reactions and side effects like fever, chills, headache, low blood cell count, and high potassium levels. Because it weakens your immune system, the medication puts you at high risk for developing infections.

Reviewed by:Last reviewed on March 7, 2024
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What is Thymoglobulin?

What is Thymoglobulin used for?

  • To prevent rejection in people who've just had a kidney transplant
  • To treat rejection in people who've had a kidney transplant

How Thymoglobulin works

Thymoglobulin is a type of protein called a depleting polyclonal antibody. It works by depleting (or wiping out) the white blood cells (T cells and B cells) that would otherwise work to reject your transplanted organ. This is thought to help prevent and treat organ rejection.

Drug facts

Common BrandsThymoglobulin
Drug ClassDepleting polyclonal antibody
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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Thymoglobulin dosage

Typical dosage for Thymoglobulin

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What are alternatives to Thymoglobulin?

There are a number of medications that your doctor can prescribe in place of Thymoglobulin. Compare a few possible alternatives below.
Thymoglobulin
Used for:
  • To prevent rejection in people who've just had a kidney transplant
  • To treat rejection in people who've had a kidney transplant
Used for:
  • Prevention of kidney transplant rejection

References

Best studies we found

Bamoulid, J., et al. (2016). Anti-thymocyte globulins in kidney transplantation: Focus on current indications and long-term immunological side effects. Nephrology Dialysis Transplantation.

Genzyme Corporation. (2024). Thymoglobulin (anti-thymocyte globulin)- rabbit injection, powder, lyophilized, for solution [package insert]. DailyMed.

Karuthu, S., et al. (2012). Common infections in kidney transplant recipients. Clinical Journal of the American Society of Nephrology.

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