Supprelin LA (histrelin) helps prevent early puberty in children 2 years of age and older. The medication works well to delay puberty, but it's an implant that is placed under your skin during a minor surgical procedure.
Supprelin LA (histrelin) is a hormone similar to one your body naturally makes called gonadotropin-releasing hormone (GnRH). It lowers reproductive hormone levels, estrogen and testosterone, which are a part of the process of puberty.
| Common Brands | Supprelin LA |
|---|---|
| Drug Class | Gonadatropin releasing hormone (GnRH) agonist |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Contact your healthcare provider immediately if you experience any of the following.
Side effects that you should report to your care team as soon as possible:
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
Supprelin LA (histrelin) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Supprelin LA (histrelin) is an artificial hormone similar to one your body makes, called gonadotropin-releasing hormone (GnRH). Supprelin LA (histrelin) can cause worsening of puberty symptoms when first started. These symptoms should go away within the first 4 weeks of therapy.
Supprelin LA (histrelin) is contained within an implant, which requires a surgical procedure to insert it and remove it. Talk to your healthcare provider about risks of the implant and the minor surgery.
People taking medications similar to GnRH, like Supprelin LA (histrelin), may have difficulty controlling emotions. Symptoms of emotional changes include crying, irritability, impatience, anger, and aggression (anger). As a parent, watch your child for changes in behaviors and emotions.
People taking medications similar to GnRH, like Supprelin LA (histrelin), may experience convulsions. If you experience tight muscles, uncontrollable movements, or painful cramping, call your healthcare provider right away.
This medication is a 50 mg implant that is placed under your skin during a minor surgical procedure once every 12 months. The implant is placed in the inside area of your upper arm above the elbow.
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This is when children have signs of sexual development (breast growth, penis growth, vaginal bleeding, or pubic hair) younger than normally seen. Children with early sexual development younger than the age of eight (girls) or nine (boys) years should be seen by their healthcare provider.
In multiple studies, the most common side effect reported was discomfort, bruising, soreness, pain, tingling, itching, or swelling of the arm where the medication was implanted (placed).
Supprelin LA is placed once every 12 months. It's removed when your child reaches an appropriate age for puberty to begin based on their gender.
The arm with the implanted medication should stay dry for at least 24 hours so avoid bathing or swimming. Also, it's best to avoid a lot of exercise, especially involving the arm with the implant. The surgical strips should not be removed; they are designed to fall off on their own after a few days.
Some people taking Supprelin LA might experience more crying, anger, irritability, or restlessness (impatience). If you have a history of emotional or psychiatric problems, let your healthcare provider know before starting this medication.
