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Rezira

hydrocodone / pseudoephedrine
Used for Cold Symptoms, Cough, Nasal Congestion

Rezira (hydrocodone / pseudoephedrine) is a combination medication used to treat cough and stuffy nose. It shouldn't be used in children under the age of 18 because of the risk of overdose. It should be used with caution in adults because of the risk of serious breathing problems. This medication is no longer available on the market.

Reviewed by:
reviewerShifali Patel, PharmD
reviewerMichelle Nguyen, PharmD
Last reviewed on January 9, 2022
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What is Rezira (hydrocodone / pseudoephedrine)?

Drug facts

Common BrandsRezira(brand no longer available)
Drug ClassOpioid / Decongestant
Controlled Substance ClassificationSchedule II
Generic StatusNo lower-cost generic available
AvailabilityDiscontinued
Common questions about Rezira

Common questions about Rezira

Rezira is a combination medication used to treat symptoms of a common cold, such as cough and stuffy nose. Hydrocodone is an opioid that works on the cough center in your brain to prevent coughing. Pseudoephedrine (Sudafed) is a decongestant that relieves stuffiness in your nose. Rezira should be used carefully because it can become habit-forming and lead to life-threatening breathing problems and overdose, especially when combined with alcohol.

No. Rezira is no longer available as a brand or generic medication in the United States.

It's unknown why Rezira was discontinued. According to the U.S. Food and Drug Administration (FDA), Rezira wasn't discontinued because it was unsafe or didn't work well. It's possible that it was removed from the market due to the availability of other medications to treat cough and stuffy nose.

If you used Rezira in the past or if you currently have a cough or stuffy nose, discuss other options with your healthcare provider. Depending on the nature of your symptoms and your medical history, your provider will help guide you to a medication that's best for you.

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Rezira (hydrocodone / pseudoephedrine) dosage

Typical dosage for Rezira (hydrocodone / pseudoephedrine)

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Interactions between Rezira (hydrocodone / pseudoephedrine) and other drugs

Rezira (hydrocodone / pseudoephedrine) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Rezira (hydrocodone / pseudoephedrine). Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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