Medicare: Your GoodRx guide
Learn the ins and outs of Medicare with our comprehensive guide that covers eligibility, coverage, costs, and more.
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Common Medicare glossary terms
The Medicare Annual Notice of Change (ANOC) is a letter for people enrolled in Medicare Advantage plans and anyone with Medicare Part D prescription coverage. People with Medicare Advantage or original Medicare (Part A and/or Part B) can have Part D plans. The ANOC informs enrollees about any changes to their benefits for the coming coverage year. By law, Medicare Advantage and Part D plans must send the ANOC to enrollees by September 30 — which is before the annual Medicare open enrollment period of October 15 to December 7. Even if you have the same plan, your benefits could change year to year.
A premium is the cost of having a health insurance plan and is usually paid monthly. Medicare enrollees may pay several premiums. Most people don’t pay anything for Part A hospital insurance, but some people do depending on how long they worked and paid taxes. For outpatient and preventive coverage, the Part B standard premium is $185 a month in 2025, but people with higher incomes pay more. Your premium for Medicare Advantage plans will vary, but even so-called “zero premium” plans require you to pay your Part B premium. Part D premiums range in price, but the average is about $47 a month in 2025. If you have original Medicare and a Medigap supplement plan, you have an additional premium for that coverage.
A deductible is the amount you pay out of pocket before your Medicare plan begins cost-sharing. In 2025, the Part A deductible is $1,676 per benefit period. The Part B deductible is $257 for the year, but you can access certain preventive care — including some vaccines — without meeting your deductible. Medicare Advantage deductibles vary and your Part D deductible can’t exceed $590 in 2025.
Original Medicare has no annual out-of-pocket maximum. Medicare Advantage plans have out-of-pocket limits. In 2025, they are $9,350 for in-network covered services and $14,000 for in-network and out-of-network covered services combined.
Starting January 1, 2025, anyone with Part D coverage had the option to use the Medicare Prescription Payment Plan for their out-of-pocket medication costs instead of paying upfront at the pharmacy. This plan doesn’t provide savings, but allows you to spread prescription costs — including your deductible — over the year. Making payments can be particularly helpful for people who may skip or delay picking up prescriptions because of high costs early in the year. Also in 2025, the Part D out-of-pocket limit dropped to $2,000.
After a Medicare enrollee meets the Part D deductible (if the plan has one), the health insurance begins cost sharing. The initial coverage phase means you pay coinsurance or a copay for covered prescriptions.
When you reach the $2,000 out-of-pocket maximum, your Part D plan pays for 100% of covered medications for the rest of the year.
How to save on drugs with Medicare
Medicare Part D is the part of Medicare that helps cover prescription medications, including both brand name and generic. It also includes coverage for certain vaccines that aren’t covered by Part B, as well as some medical supplies.
Even with Medicare Part D coverage, you may still have out-of-pocket costs such as premiums, deductibles, copayments, and coinsurance. As of 2025, Medicare Part D plans include a $2,000 annual out-of-pocket cap. Once you reach this limit, your plan covers the full cost of your covered medications for the rest of the year.
Still, there are several ways to reduce your prescription medication cost. From GoodRx coupons to patient assistance programs, here are ways you can save money on the medications you need.
1. See if you qualify for Medicare’s Extra Help program
The Medicare Extra Help/Low-Income Subsidy program is a federally funded program for people covered under a Medicare Part D plan. It helps reduce enrollees’ out-of-pocket costs by limiting their deductibles and copays. To qualify, your income and assets fall below a certain limit.
If you’re eligible, you may receive:
No monthly premiums for Medicare Part D
No Medicare Part D deductible
Low copays for prescription medications
2. Use GoodRx coupons
You can’t combine GoodRx coupons with Medicare, but you can choose to use a coupon instead of your insurance if it results in a lower price.
Here’s how to download a GoodRx coupon:
Go to the GoodRx website, or download the GoodRx app on your phone.
Search for your prescription medication.
Enter your prescribed dose and quantity, then set your location.
Compare prices across different pharmacies in your area.
Click “Find the lowest prices” or press “Enter.”
You can have the coupon sent by text or email, or print it out.
To apply the discount, show the coupon at the pharmacy when you fill your prescription. Ideally, this is done at drop-off before the prescription is filled.
3. Consider the Medicare Prescription Payment Plan
The Medicare Prescription Payment Plan is a new program that can help make paying for medications more manageable. It’s open to anyone with a standalone Part D plan or those with Medicare Advantage plans that offer prescription medication coverage.
There is no cost to participate in the Medicare Prescription Payment Plan and participation is voluntary. Instead of paying for the total cost of your medications up front at the pharmacy, the payment plan allows you to spread the cost into smaller payments during the year. If you join, you will continue to pay your premium every month as well as an additional monthly amount on your payment plan. It’s a good idea to review how the Medicare Prescription Payment Plan works to determine if it’s right for you.
4. Compare Part D plans during open enrollment
Medicare open enrollment, which takes place every year from October 15 to December 7, is your chance to switch plans if another option offers better prescription medication coverage or lower costs. Plan costs and coverage details can change each year, so it’s important to review your options.
Here are some steps to help you compare plans:
Make a list of all your medications and what dosages you take.
Visit Medicare’s plan finder tool.
Enter the names of your prescription medications to see which plans offer the best coverage.
Look at premiums, deductibles, and medication costs for each plan. Plans usually change their formularies, premiums, and copays annually.
Check if your preferred pharmacy is in each plan's network.
5. Get a 90-day supply
Opting for a 90-day supply instead of a monthly refill of your medication might help reduce your long-term out-of-pocket costs. Many insurance plans offer lower copays or bulk pricing for 3-month prescriptions.
If your medication is covered under your plan, see if your insurer’s mail-order or specialty pharmacy provides savings on a 90-day supply. If they do, ask your prescriber to write a prescription for a 90-day quantity to take advantage of these potential savings.
6. Ask about the generic version of your medication
Some medications have a generic version, and they generally cost less than the brand-name prescriptions. Generic medications are just as safe and effective as brand-name medications, so it’s an option worth considering to reduce your cost. Ask your prescriber about switching to a generic version of your medication to save money.
7. Consider lower-cost alternative medications
There may be other medications that help manage your condition, and they may cost less. If your medication is costly or not covered by your insurance, talk to your prescriber about lower-cost alternatives that might be a good option for you. Alternatives might have better insurance coverage or lower costs.
8. Learn more about patient assistance programs
Patient assistance programs (PAPs) offer free or low-cost medications to uninsured and low-income consumers. These programs, which primarily offer savings on brand-name medications, are usually run by private pharmaceutical companies or nonprofit organizations. You must meet certain qualifications and complete paperwork to receive savings from PAPs. However, some PAPs exclude Medicare recipients, so it’s important to review the program’s rules and requirements carefully.
9. Check state-funded resources
Depending on where you live, your state may offer programs to help you navigate prescription medication costs. A good place to start is your local Department of Aging. This U.S. Department of Health and Human Services office can help you find the best Medicare plan for the coverage you need.
Some states even have their own cost-saving programs for older adults. For example, Pennsylvania runs PACE and PACENET. These programs help eligible residents get prescription medications at reduced costs.
Alternatively, you can find out if your state has a State Pharmaceutical Assistance Program by using Medicare’s search tool. These programs are state-run and help qualifying residents pay for prescription medications.
10. Use a health savings account to pay for prescription medications
Although you can’t contribute to a health savings account (HSA) after enrolling in Medicare, you can still use any remaining funds in your account to pay for qualified medical expenses. An HSA allows you to use tax-free dollars to pay for eligible prescription medications. The money in your account does not expire so you can use your funds at any time to reduce your out-of-pocket medication costs.
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Frequently asked questions about Relyvrio
Relyvrio comes in packets of powder that need to be mixed with 8 oz (or 1 cup) of room-temperature water before taking your dose. Don't take the medication directly from the packet without mixing it with water first. Once mixed with water, make sure to take your dose within 1 hour. The mixture can be taken by mouth or through a feeding tube. Relyvrio is best taken before a snack or meal.
No. There's currently no cure for ALS, but there are medications, like Relyvrio, available that might slow the worsening of symptoms. These medications can help people with ALS have a better quality of life. Unfortunately, Relyvrio won't bring back any motor function you've already lost. Discuss the different treatment options with your provider.
At the end of a 6-month study of 137 people with ALS, people treated with Relyvrio had better daily functioning than people who took a placebo. Characteristics of daily functioning that were studied included people's abilities to talk, swallow, write by hand, cut food, walk, and more. Additionally, the study suggests that Relyvrio might give people with ALS more time to live, but more research is needed. There's a study that's currently going on looking at how safe the medication is and how well Relyvrio works to treat ALS in a larger group of people. This larger study is expected to end in 2024.
Relyvrio can interact with aluminum-based antacids (e.g., Mylanta, Gaviscon). These antacids can can lower how much Relyvrio your body absorbs. This could cause Relyvrio to work less well for you. It's recommended that you avoid aluminum-based antacids while you're taking Relyvrio. Other antacids, like Tums, aren't known to interact with Relyvrio. It's important to tell your pharmacist or provider about all of your medications before starting treatment and before taking anything new. They can help check if your medications are safe to take together with Relyvrio. If you need to take an antacid while you're taking Relyvrio, ask your pharmacist for recommendations that are safe for you.
It's recommended to only mix Relyvrio in room temperature water for your dose. But the medication can have a bitter aftertaste. To help with this aftertaste, there are a few things you can try. You could try using a mint-flavored mouth spray right before or after taking your dose. You could also drink milk or eat some honey right after taking your dose. It's recommended to eat a snack or meal right after your dose, which could help with the aftertaste too. But avoid drinking fruit juice right after your dose since this could actually make the bitter aftertaste of Relyvrio worse.
Relyvrio commonly causes stomach side effects, like diarrhea, nausea, and stomach pain. But there are a few things you can do to help manage them. If you have diarrhea or feel nauseous and end up vomiting, make sure to drink plenty of fluids. This helps prevent dehydration that can happen if you have episodes of diarrhea or vomiting. Avoiding spicy or fried foods and eating a meal after your dose can help with stomach upset. You can also try ginger or peppermint to help with nausea, if your provider says it's okay to do so. In clinical studies, these side effects occurred more often during the first 3 weeks of treatment. This suggests they might get better over time. If you're having bothersome side effects, talk with your provider about ways to help manage them.
Always discuss your medical history with your provider so they can make sure Relyvrio is safe for you to take. In general, you can take Relyvrio if you have mild kidney or liver problems. But if you have moderate or severe kidney or liver problems, it's recommended that you avoid this medication. Discuss the risks and benefits of taking Relyvrio with your provider. In some cases, they might be able to check your liver and kidney health during treatment.
Both medications help slow the worsening of ALS, but there are some differences. For one, Relyvrio is only available as a powder that you mix with water and take by mouth or through a feeding tube. On the other hand, Radicava (edaravone) is available in two forms: a liquid that can be taken by mouth or through a feeding tube and an injection through the veins (intravenous, IV). Also, Relyvrio is generally taken twice a day, whereas Radicava (edaravone) is taken once a day. Additionally, Radicava (edaravone) is taken in treatment cycles with two-week breaks in between each cycle, but Relyvrio is typically taken continuously without any breaks. Follow up with your provider for more information on ALS treatments. They can help find the best treatment option for you.
