What should I watch for?
Visit your doctor or health care professional for regular check ups. Tell your doctor if your symptoms do not improve or if you get new symptoms. If you get a skin rash, stop taking your medicine and contact your doctor right away.
Do not get pregnant while taking this drug. Talk to your doctor about effective birth control methods.
You may need to take folinic acid while you are taking this medicine. Talk to your health care professional.
Common and Rare Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Black, tarry stools
blood in urine or stools
cough or hoarseness
fever or chills
irritation or soreness of tongue
lower back or side pain
painful or difficult urination
pinpoint red spots on skin
unusual bleeding or bruising
Bleeding or crusting sores on lips
chest pain or discomfort
muscle cramps or pain
redness, blistering, peeling, or loosening of skin
sores, ulcers, and/or white spots in mouth
unusual tiredness or weakness
Frequency not known
Blood in urine
fast, slow, or irregular heartbeat
joint or muscle pain
pounding or rapid pulse
puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
red, irritated eyes
red skin lesions, often with a purple center
shortness of breath
tightness in chest
unexplained bleeding or bruising
Symptoms of overdose
Abdominal or stomach pain
vomiting (severe and continuing)
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.