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Pyrimethamine

Pyrimethamine Side Effects

Dalga Surofchy, PharmD, APhCydnee Ng, PharmD
Reviewed by Dalga Surofchy, PharmD, APh, Cydnee Ng, PharmD
Last reviewed on July 15, 2021

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Loss of appetite
  • Vomiting

Less Common Side Effects

  • Anemia (low red blood cell count)
  • Getting sick often
  • Bleeding more easily
  • Changes or swelling to tongue
  • Blood in urine
  • Changes to heart rhythm

Pyrimethamine serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Allergic reaction

Source: DailyMed

The following Pyrimethamine side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

Chest pain

dry cough

fever

rapid or trouble breathing

skin rash

unusual tiredness or weakness

Incidence not known

Black, tarry stools

bleeding gums

blistering, peeling, or loosening of the skin

blood in the urine or stools

chills

cough

diarrhea

difficulty swallowing

dizziness

fainting spells

fast or irregular heartbeat

hives, itching

irritation or soreness of the tongue

joint or muscle pain

lower back or side pain

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

painful or difficult urination

pale skin

pinpoint red spots on the skin

red, irritated eyes

red skin lesions, often with a purple center

sore throat

sores, ulcers, or white spots on the lips or in the mouth

swollen glands

tightness in the chest

unusual bleeding or bruising

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Loss of appetite

vomiting

weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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