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ProQuad

measles, mumps, rubella, and varicella vaccine
Used for Chickenpox, Measles
Used for Chickenpox, Measles

ProQuad (MMRV vaccine) is a combination live-attenuated vaccine. It offers protection against measles, mumps, rubella, and varicella (MMRV) in children age 1 through 12 years old. ProQuad (MMRV vaccine) is given as an injection under the skin or into the muscle. The dosing schedule is made up of 2 injections at specific ages. Common side effects include pain, tenderness, and soreness at the injection site and fever.

Last reviewed on January 13, 2025
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What is ProQuad (MMRV vaccine)?

What is ProQuad (MMRV vaccine) used for?

How ProQuad (MMRV vaccine) works

ProQuad (MMRV vaccine) is a live-attenuated vaccine. It's made from weakened versions of the measles, mumps, rubella, and varicella (MMRV) viruses. The vaccine helps your body's immune system make antibodies against the viruses. These antibodies attack the viruses if they get into the body to help protect against severe illness.

Are you looking for information on MMR II (measles, mumps, and rubella vaccine) instead?

Drug Facts

Common BrandsProQuad
Drug ClassVaccine
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only

More on ProQuad (MMRV vaccine) essentials

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What are the side effects of ProQuad (MMRV vaccine)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Pain, tenderness, or soreness at the injection site (up to 21%)
  • Fever (up to 20%)
  • Redness at the injection site (up to 12%)
  • Swelling at the injection site (up to 9%)

Other Side Effects

Note: Side effect data from children who got ProQuad (MMRV vaccine) injected under the skin. Side effects might differ for injections given into the muscle.

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious allergic reaction: hives, rash, shaking, itching, nausea, flushing, dizziness, shortness of breath, chest pain
  • Febrile seizure (fever with seizures): eye rolling, stiff arms and legs, passing out, shaking of arms and legs
When do ProQuad (MMRV vaccine) possible side effects begin and end?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Reaction at the injection site (e.g., pain, tenderness, soreness)

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of ProQuad (MMRV vaccine)

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Pros

Combination vaccine that protects against 4 viruses

Full vaccination requires just 2 injections

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Cons

Must be given by a healthcare professional as an injection under the skin or into the muscle

Not recommended by CDC as the vaccine of choice for the first dose of the series to protect against MMRV in children age 1 to under 4 years

Might not be a safe choice for people with an allergy to eggs

pharmacist-tips

Pharmacist tips for ProQuad (MMRV vaccine)

pharmacist
  • Read the vaccine information statement for more information on ProQuad (MMRV vaccine). Keep in mind that ProQuad (MMRV vaccine) might not guarantee 100% protection from measles, mumps, rubella, and varicella infection, but it helps prevent severe illness. Ask a healthcare professional (HCP) if you have any questions.

    • Side effects like pain, tenderness, and soreness at the injection site are common within a few hours after your child gets vaccinated with ProQuad (MMRV vaccine). Try using warm compresses or ice packs or moving the limb around to help with these side effects. They typically go away in 1 to 2 days. But contact an HCP if the side effects last longer or if they're severe.

      • Don't give your child aspirin to help with fever or pain for at least 6 weeks after they get vaccinated with ProQuad (MMRV vaccine). It's best not to give them aspirin even after this time, unless recommended by an HCP. Aspirin raises the risk for Reye's syndrome in children under 18 years of age.

        • You should reschedule your child's vaccination with ProQuad (MMRV vaccine) if your child is sick with a fever that's higher than 101.3 degrees Fahrenheit. Wait until they recover so that their immune system can work its best to provide protection against MMRV. Ask your child's HCP if it's okay to get the vaccine if your child is mildly sick, such as with a cold or low-grade fever.

          • Make sure to keep a record of all your child's immunizations and show it to their HCP before they receive any vaccine, including ProQuad (MMRV vaccine). The HCP can make sure your child is getting all their vaccinations on schedule.

            • You can report any severe reactions to ProQuad (MMRV vaccine) to the vaccine adverse event reporting system (VAERS) by visiting their website or by calling 1-800-822-7967.

              faqs

              Frequently asked questions about ProQuad (MMRV vaccine)

              What is in ProQuad (MMRV vaccine)?
              ProQuad (MMRV vaccine) contains four active ingredients: the live, but weakened, forms of measles, mumps, rubella, and varicella virus. It helps the immune system make antibodies against these viruses to provide protection from severe illness that they can cause. There are also several inactive ingredients that have different purposes for manufacturing and stability. Examples include the stabilizer called gelatin and a small amount of the antibiotic called neomycin to prevent the vaccine from getting germs in it.
              Is ProQuad (MMRV vaccine) a live vaccine?
              Yes, ProQuad (MMRV vaccine) is a live-attenuated vaccine. This means that the vaccine is made by using live, but weakened, forms of the measles, mumps, rubella, and varicella viruses. Live vaccines have the advantage of providing strong and long-lasting protection. But live vaccines aren't generally safe for children with a weakened immune system. This is because they might be more likely to get sick from the weakened forms of the viruses in the vaccine itself. Make sure the healthcare team knows about all of your child's medical conditions and medications before they get vaccinated with ProQuad (MMRV vaccine). The care team can make sure ProQuad (MMRV vaccine) is safe for your child.
              How is ProQuad (MMRV vaccine) administered?
              ProQuad (MMRV vaccine) is an injection that's given either into the muscle or under the skin. It's administered by a trained healthcare professional (HCP) at a local pharmacy or medical office.
              What is the age limit for ProQuad (MMRV vaccine)?
              ProQuad (MMRV vaccine) is approved for children who are 12 months through 12 years of age. The first dose of ProQuad (MMRV vaccine) is recommended at 12 to 15 months of age. And the second dose is recommended at 4 to 6 years of age. Keep in mind that vaccination with ProQuad (MMRV vaccine) can be started anytime before your child turns 13 years old, as long as the two doses are at least 3 months apart. Speak with your child's healthcare professional if you have more questions about when to get your child vaccinated with ProQuad (MMRV vaccine) and for help with scheduling.
              Can ProQuad (MMRV vaccine) be given to adults?
              No, ProQuad (MMRV vaccine) isn't approved for adults. It's only approved for use in children 12 months through 12 years of age. Children age 13 years and older and adults who need catch-up vaccination against measles, mumps, rubella, and varicella to get the MMR vaccine and Varivax (varicella vaccine) as two separate vaccines. Talk to a member of your care team about your options if you need catch-up vaccination for MMRV.
              How common is it to get a rash after ProQuad (MMRV vaccine)?
              It's not very common to get a rash after you get vaccinated with ProQuad (MMRV vaccine). Across multiple studies, no more than 5% of children who received ProQuad (MMRV vaccine) had rash. If a mild rash does appear shortly after your child gets vaccinated with ProQuad (MMRV vaccine), you can typically help manage the itchiness with cool compresses. Ask a healthcare professional (HCP) first about using anti-itch lotions like calamine or a children's form of an over-the-counter antihistamine like cetirizine (Zyrtec). They can make sure these products are safe for your child. Also speak with an HCP if the rash doesn't go away on its own or if it's severe because it can be a sign of many other medical issues.
              How do you reduce a fever after ProQuad (MMRV vaccine)?
              A fever is one of the most common side effects from ProQuad (MMRV vaccine). Some things you can do to help reduce a fever or try to make it more comfortable for your child include cool compresses using warm water and keeping the room cool. Also have your child wear light clothing and try to encourage them to drink plenty of fluids throughout the day. Ask a healthcare professional first about whether it's safe to give your child the children's version of acetaminophen (Tylenol) or ibuprofen (Advil) to help reduce the fever. Don't give your child aspirin unless a healthcare professional recommends it because of the risk of a serious condition called Reye's syndrome.
              What's the difference between the MMR and MMRV vaccines?
              The MMR vaccine and MMRV vaccine (also called ProQuad) both protect against measles, mumps, and rubella. ProQuad (MMRV vaccine) also protects against chickenpox (varicella). The MMR vaccine is available for anyone 1 year or older, including adults. But ProQuad (MMRV vaccine) is only approved for children between 1 and 12 years old. The CDC recommends that children age 1 to under 4 years get the MMR vaccine and chickenpox vaccine as separate vaccine series for their first dose against MMRV. Studies showed that children who got ProQuad (MMRV vaccine) were more likely to have a fever or febrile seizure than those who got the MMR vaccine and Varivax (varicella vaccine) separately. Febrile seizures are usually harmless but can be scary and hard for parents to recognize. Ask a healthcare professional about differences between the MMR vaccine and ProQuad (MMRV vaccine).
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              What are the risks and warnings for ProQuad (MMRV vaccine)?

              ProQuad (MMRV vaccine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Risk of severe allergic reaction if allergic to eggs

              • Risk factors: Severe allergy to eggs or egg products

                Let the healthcare professional (HCP) know if your child has a severe allergy to eggs. ProQuad (MMRV vaccine) contains egg protein. People with a severe allergy to eggs or egg products might be at higher risk of an allergic reaction to this vaccine. The HCP will weigh the risks and benefits for your child to get ProQuad (MMRV vaccine).

                Call 911 right away if you notice symptoms of a severe allergic reaction, like feeling faint, swelling of the face, closing of the throat, difficulty breathing, hives or rash, dizziness, shaking, nausea, or chest pain.

                risk-warning

                Risk of fever and febrile seizure

                • Risk factors: Personal or family history of febrile seizure | Children age 1 to 2 years old who haven't been vaccinated against MMRV or who haven't had these infections

                  Although rare, children age 1 to 2 years old might be at risk for fever with or without seizures (febrile seizures) within the first 2 weeks after they've gotten the first dose of ProQuad (MMRV vaccine). Let your child's pediatrician, primary care provider, or HCP know if your child has ever had a febrile seizure before they get vaccinated with ProQuad (MMRV vaccine). If so, the HCP might recommend that your child get the MMR vaccine and Varivax (varicella vaccine) as separate vaccines to lower the risk of fever with or without seizures.

                  risk-warning

                  Avoid use in people with a weakened immune system

                  • Risk factors: Weakened immune system from medical conditions or medications

                    Let the HCP know if your child has a weakened immune system, like from a genetic condition or from human immunodeficiency virus (HIV). In general, the CDC's immunization guidelines don't recommend ProQuad (MMRV vaccine) for these immunocompromised people. People with a weakened immune system might get seriously sick from the weakened viruses in the vaccine. Talk with your child's pediatrician or primary care provider if you're not sure whether your child can get vaccinated with ProQuad (MMRV vaccine).

                    risk-warning

                    Rare risk of spreading varicella (chickenpox) virus to others

                    Although rare, it's possible for your child to spread MMRV (particularly varicella, the chickenpox virus) to other people after they get vaccinated with ProQuad (MMRV vaccine). This typically isn't a concerning problem for most people. But some people, like pregnant people who've never had chickenpox, premature newborns, and people with a weak immune system, might be at higher risk for infection. If this happens, though, most cases are mild without any complications.

                    To be safe, children who get ProQuad (MMRV vaccine) should try to avoid close contact with high-risk people for up to 6 weeks after vaccination. Talk with your child's healthcare team about your options if avoiding close contact with high-risk people isn't possible.

                    risk-warning

                    Low platelet count

                    • Risk factors: History of having a low platelet count | Previously had a drop in platelet levels after receiving a dose of a measles, mumps, and rubella-containing vaccine

                      Some people have had low platelet counts within 4 to 6 weeks after they've gotten a measles, mumps, and rubella vaccine. Typically, this drop in platelet count is temporary.

                      For most people, the brief drop in platelet count won't cause problems. But let the HCP if your child has a medical condition that causes them to have a low platelet count. The healthcare professional can weigh the risks and benefits of using ProQuad (MMRV vaccine) for your child's vaccination.

                      Call your child's pediatrician or primary care provider if you notice that your child has bleeding that's difficult to stop, bruises that don't go away, dizziness, or confusion. These can be symptoms of a low platelet count.

                      risk-warning

                      Specific spacing needed between immune globulin therapy or blood transfusions and ProQuad (MMRV vaccine)

                      Let the HCP know whether your child has gotten a blood transfusion or received other blood products like immune globulins recently. These products can affect your child's immune response to ProQuad (MMRV vaccine). The HCP will follow specific guidelines on when it's safe for your child to get ProQuad (MMRV vaccine) before or after immune globulin therapy or a blood transfusion.

                      dosage

                      ProQuad (MMRV vaccine) dosage forms

                      The average cost for 1 dose of 0.5ml of ProQuad (MMRV vaccine) is $282.55 with a free GoodRx coupon. This is 13.5% off the average retail price of $326.64.
                      dose
                      Dose
                      DosageQuantityPrice as low asPrice per unit
                      0.5ml1 dose$282.55$282.55

                      Typical dosing for ProQuad (MMRV vaccine)

                      Each dose of the vaccine is 1 injection (0.5 mL) given under the skin or into the muscle. It's given by a trained healthcare professional (HCP).

                      • Dose 1: The first dose is typically given between 12 and 15 months of age.

                      • Dose 2: The second dose is typically given between 4 and 6 years of age.

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                      How much does ProQuad (MMRV vaccine) cost?

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                      contraindications-icon

                      ProQuad (MMRV vaccine) contraindications

                      Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because ProQuad (MMRV vaccine) will not be safe for you to take.
                      • History of allergy to previous dose of ProQuad; MMR II; Varivax; or any other vaccine against measles, mumps, rubella, or varicella

                      • History of allergy to gelatin

                      • History of anaphylaxis to neomycin

                      • Have a weakened immune system due to medical conditions or medications

                      • Sick with a fever greater than 101.3 degrees Fahrenheit

                      • Active untreated tuberculosis (TB)

                      • Currently pregnant or planning to become pregnant in the next 3 months

                      alternatives

                      What are alternatives to ProQuad (MMRV vaccine)?

                      There are a number of medications that your doctor can prescribe in place of ProQuad (MMRV vaccine). Compare a few possible alternatives below.
                      ProQuad (MMRV vaccine)
                      Used for:
                      $282.55 Lowest GoodRx priceView Prices
                      Used for:
                      • Prevention of measles, mumps, and rubella (MMR) in adults and children 1 year of age and older

                      $105.99 Lowest GoodRx priceView Prices
                      Used for:
                      $186.95 Lowest GoodRx priceView Prices
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                      References

                      Best studies we found

                      Centers for Disease Control and Prevention. (n.d.). Chickenpox (varicella).

                      Centers for Disease Control and Prevention. (2021). MMR & varicella vaccines or MMRV vaccine: Discussing options with parents.

                      Centers for Disease Control and Prevention. (2021). Q&As about vaccination options for preventing measles, mumps, rubella, and varicella.

                      View All References (14)

                      Centers for Disease Control and Prevention. (2024). Measles, mumps, rubella, varicella (MMRV) vaccine safety.

                      Centers for Disease Control and Prevention. (2024). Recommended adult immunization schedule for ages 19 years or older.

                      Centers for Disease Control and Prevention. (2024). Recommended child and adolescent immunization schedule for ages 18 years or younger.

                      Centers for Disease Control and Prevention. (2024). Timing and spacing of immunobiologics.

                      Centers for Disease Control and Prevention. (2024). Vaccines when your child is sick.

                      Centers for Disease Control and Prevention. (2024). Varicella vaccination for specific groups.

                      Centers for Disease Control and Prevention. (2024). Varicella vaccine recommendations.

                      Centers for Disease Control and Prevention. (2025). MMRV vaccine VIS.

                      Immunize.org. (2023). Varicella (chickenpox): Questions and answers.

                      MedlinePlus. (2023). Platelet count.

                      Merck Sharp & Dohme LLC. (2024). Proquad- measles, mumps, rubella and varicella virus vaccine live injection, powder, lyophilized, for suspension [package insert]. DailyMed.

                      U.S. Department of Health and Human Services. (2022). Vaccine types.

                      U.S. Food and Drug Administration. (2024). Common ingredients in FDA-approved vaccines.

                      World Health Organization. (2020). How do vaccines work?

                      GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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