ProQuad

• Risk factors: Severe allergy to eggs or egg products

Let the healthcare professional (HCP) know if your child has a severe allergy to eggs. ProQuad (MMRV vaccine) contains egg protein. People with a severe allergy to eggs or egg products might be at higher risk of an allergic reaction to this vaccine. The HCP will weigh the risks and benefits for your child to get ProQuad (MMRV vaccine).

Call 911 right away if you notice symptoms of a severe allergic reaction, like feeling faint, swelling of the face, closing of the throat, difficulty breathing, hives or rash, dizziness, shaking, nausea, or chest pain.

• Risk factors: Personal or family history of febrile seizure | Children age 1 to 2 years old who haven't been vaccinated against MMRV or who haven't had these infections

Although rare, children age 1 to 2 years old might be at risk for fever with or without seizures (febrile seizures) within the first 2 weeks after they've gotten the first dose of ProQuad (MMRV vaccine). Let your child's pediatrician, primary care provider, or HCP know if your child has ever had a febrile seizure before they get vaccinated with ProQuad (MMRV vaccine). If so, the HCP might recommend that your child get the MMR vaccine and Varivax (varicella vaccine) as separate vaccines to lower the risk of fever with or without seizures.

• Risk factors: Weakened immune system from medical conditions or medications

Let the HCP know if your child has a weakened immune system, like from a genetic condition or from human immunodeficiency virus (HIV). In general, the CDC's immunization guidelines don't recommend ProQuad (MMRV vaccine) for these immunocompromised people. People with a weakened immune system might get seriously sick from the weakened viruses in the vaccine. Talk with your child's pediatrician or primary care provider if you're not sure whether your child can get vaccinated with ProQuad (MMRV vaccine).

Although rare, it's possible for your child to spread MMRV (particularly varicella, the chickenpox virus) to other people after they get vaccinated with ProQuad (MMRV vaccine). This typically isn't a concerning problem for most people. But some people, like pregnant people who've never had chickenpox, premature newborns, and people with a weak immune system, might be at higher risk for infection. If this happens, though, most cases are mild without any complications.

To be safe, children who get ProQuad (MMRV vaccine) should try to avoid close contact with high-risk people for up to 6 weeks after vaccination. Talk with your child's healthcare team about your options if avoiding close contact with high-risk people isn't possible.

• Risk factors: History of having a low platelet count | Previously had a drop in platelet levels after receiving a dose of a measles, mumps, and rubella-containing vaccine

Some people have had low platelet counts within 4 to 6 weeks after they've gotten a measles, mumps, and rubella vaccine. Typically, this drop in platelet count is temporary.

For most people, the brief drop in platelet count won't cause problems. But let the HCP if your child has a medical condition that causes them to have a low platelet count. The healthcare professional can weigh the risks and benefits of using ProQuad (MMRV vaccine) for your child's vaccination.

Call your child's pediatrician or primary care provider if you notice that your child has bleeding that's difficult to stop, bruises that don't go away, dizziness, or confusion. These can be symptoms of a low platelet count.

Let the HCP know whether your child has gotten a blood transfusion or received other blood products like immune globulins recently. These products can affect your child's immune response to ProQuad (MMRV vaccine). The HCP will follow specific guidelines on when it's safe for your child to get ProQuad (MMRV vaccine) before or after immune globulin therapy or a blood transfusion.