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Prestalia

perindopril/amlodipine
Used for Hypertension
Used for Hypertension

Prestalia (perindopril / amlodipine) is a combination medication used to treat high blood pressure and helps lower your risk for heart attacks and other heart-related deaths. However, it's much more expensive than other similar medications.

Reviewed by:
Carter Havican, PharmD
reviewer
Allison Gourley, PharmD
Last reviewed on September 20, 2021
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageContraindicationsAlternativesPricesMedicare
basics-icon

What is Prestalia (perindopril / amlodipine)?

What is Prestalia (perindopril / amlodipine) used for?

  • High blood pressure

How Prestalia (perindopril / amlodipine) works

Prestalia (perindopril / amlodipine) is a combination of two blood pressure medications: perindopril and amlodipine.

  • Perindopril is an ACE inhibitor. It works by blocking a chemical that normally tightens your blood vessels. This then lowers your blood pressure by allowing your blood vessels to relax.

  • Amlodipine is a calcium channel blocker (CCB) that also causes your blood vessels to relax and widen, which helps lower your blood pressure.

Are you looking for information on perindopril or amlodipine (Norvasc) for blood pressure instead?

Drug Facts

Common BrandsPrestalia
Drug ClassACE inhibitor / CCB
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
basics-icon

What are the side effects of Prestalia (perindopril / amlodipine)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Swelling in legs or ankles (peripheral edema) (7%)
  • Cough (3%)
  • Headache (3%)
  • Dizziness (3%)

Other Side Effects

  • Rash
  • Nausea
  • Diarrhea

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious allergic reactions: rash, hives, difficulty breathing, swelling in face, mouth, lips, tongue, or throat
  • Very high potassium level: nausea, weakness, chest pain, irregular heartbeat
  • Kidney problems: fatigue, confusion, swelling in your feet or ankles, or little to no urination
  • Liver problems: yellowing of your skin or eyes, nausea, vomiting, pain in upper right side of your stomach

Source: DailyMed

pros-and-cons

Pros and cons of Prestalia (perindopril / amlodipine)

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Pros

Lowers your risk of heart attack and stroke

Has two effective blood pressure lowering drugs in one pill

Can help protect the kidneys in certain people

Once daily dosing

thumbs-down

Cons

Might cause more side effects than simliar drugs since it has two medications

Very expensive compared to each drug alone or other similar drugs for blood pressure

Cannot use if pregnant or breastfeeding

Can cause a dry cough

pharmacist-tips

Pharmacist tips for Prestalia (perindopril / amlodipine)

pharmacist

  • You may feel mild dizziness for the first few days after starting Prestalia (perindopril / amlodipine). This should get better over time as your body adjusts to your lower blood pressure. Tell your healthcare provider if your dizziness doesn't get better after a few days.

    • If you develop a dry cough after starting Prestalia (perindopril / amlodipine) and it doesn't get any better after one week, let your healthcare provider know. This may be a symptom from Prestalia (perindopril / amlodipine) or a cough from a different condition. If it is from this medication, the cough will go away within a month after you stop it.

      • If your healthcare provider recommended a low-salt diet, make sure to avoid salt-substitutes and supplements that contain potassium. Combining potassium with Prestalia (perindopril / amlodipine) may cause your blood potassium to reach dangerous levels.

        faqs

        Frequently asked questions about Prestalia (perindopril / amlodipine)

        Can I take Prestalia (perindopril / amlodipine) if I'm pregnant or planning to become pregnant?
        No. Never take Prestalia (perindopril / amlodipine) if you're pregnant. It can cause birth defects and harm to your unborn baby. If you take Prestalia (perindopril / amlodipine) and find out you're pregnant or think you could be pregnant, stop it right away and tell your healthcare provider.
        Will Prestalia (perindopril / amlodipine) make me urinate more often?
        No. While it's common for some blood pressure medications to include diuretics (water pills), this one does not. Prestalia (perindopril / amlodipine) contains an ACE inhibitor (perindopril) and a calcium channel blocker (amlodipine), which work differently than water pills to lower your blood pressure.
        Can I continue to take ibuprofen (Advil) or naproxen (Aleve) for pain?
        You should avoid regular use of those medications, because they can damage your kidneys and worsen your blood pressure while on Prestalia (perindopril / amlodipine). It's okay to use acetaminophen (Tylenol) for pain since that won't affect your blood pressure. Always make sure to talk with your healthcare provider or pharmacist about which medications are safe to take when using Prestalia (perindopril / amlodipine).
        Does Prestalia (perindopril / amlodipine) cause weight gain?
        Prestalia (perindopril / amlodipine) doesn't cause weight gain. However, Prestalia (perindopril / amlodipine) might cause your body to hold onto water in your legs or ankles, a side effect called edema. Tell your healthcare provider if this happens to you after starting Prestalia (perindopril / amlodipine).
        Can I drink alcohol when using Prestalia (perindopril / amlodipine)?
        Drinking alcohol while taking Prestalia (perindopril / amlodipine) can raise your risk of side effects, especially dangerous changes to your blood pressure. You should avoid alcohol use to prevent serious side effects while taking Prestalia (perindopril / amlodipine).
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        What are the risks and warnings for Prestalia (perindopril / amlodipine)?

        Prestalia (perindopril / amlodipine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

        risk-warning

        Harm to unborn baby

        Prestalia (perindopril / amlodipine) can cause serious injury or death to an unborn baby. If you are pregnant or think you may be pregnant, stop taking Prestalia (perindopril / amlodipine) right away and talk to your healthcare provider.

        risk-warning

        Swelling in face or other body parts

        • Risk factors: Black people | Taking Prestalia (perindopril / amlodipine) with an mTOR inhibitor, like everolimus (Afinitor) or a neprilysin inhibitor, like Entresto (sacubitril/valsartan)

          Angioedema (swelling around the eyes, lips, face, throat, hands, or feet) can happen at any time while you're taking Prestalia (perindopril / amlodipine). Tell your healthcare provider right away if you have any of these symptoms.

          risk-warning

          Low blood pressure

          • Risk factors: Taking other medications that lower blood pressure | Dehydration

            Prestalia (perindopril / amlodipine) lowers your blood pressure and can make you feel lightheaded or dizzy. These symptoms can be especially severe if you're dehydrated, have a low amount of salt in your body, or are taking other blood pressure medications. Be very mindful of this effect when first starting this medication and for 2 weeks after a dose change.

            risk-warning

            High potassium (hyperkalemia)

            • Risk factors: Current kidney problems | Diabetes | Taking other medications that raise your potassium | Use of certain salt substitutes

              Prestalia (perindopril / amlodipine) can raise the amount of potassium in your body. Having high potassium levels can cause issues, including heart problems. Your provider should order routine blood tests to make sure your potassium is within normal range. If you have any signs of muscle weakness, chest pain, irregular heartbeart, or nausea and vomiting, tell your provider right away.

              risk-warning

              Worsening kidney problems

              • Risk factors: History of kidney problems

                In some rare cases, Prestalia (perindopril / amlodipine) can cause kidney failure. You'll need blood tests done to check your kidney function before starting Prestalia (perindopril / amlodipine) and regularly after. Tell your provider if you are not urinating as much as usual or if your urine is dark in color even when you're hydrated.

                risk-warning

                Liver damage

                Although rare, ACE inhibitors like Prestalia (perindopril / amlodipine) can cause liver damage. You'll need blood tests done to check your liver function before starting Prestalia (perindopril / amlodipine) and regularly after. Tell your provider if your skin or eyes turn yellow in color, if you have dark-colored urine, or belly pain and swelling.

                dosage

                Prestalia (perindopril / amlodipine) dosage forms

                tablet
                Tablet
                DosageQuantityPrice as low asPrice per unit
                7mg/5mg30 tablets$183.00$6.10
                14mg/10mg30 tablets$173.26$5.78

                Typical dosing for Prestalia (perindopril / amlodipine)

                The typical starting dose for Prestalia (perindopril / amlodipine) is 3.5 mg/2.5 mg (perindopril/amlodipine) by mouth once daily. If needed, your provider will adjust your dose after a week or two. The maximum dose is 14 mg/10 mg (perindopril/amlodipine) by mouth once daily.

                contraindications-icon

                Prestalia (perindopril / amlodipine) contraindications

                Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Prestalia (perindopril / amlodipine) will not be safe for you to take.

                • Use of aliskiren with Prestalia (perindopril / amlodipine) in people with diabetes

                • Use of a neprilysin inhibitor (like Entresto) with Prestalia (perindopril / amlodipine)

                • Use of Prestalia (perindopril / amlodipine) within 36 hours of using Entresto

                alternatives

                What are alternatives to Prestalia (perindopril / amlodipine)?

                There are a number of medications that your doctor can prescribe in place of Prestalia (perindopril / amlodipine). Compare a few possible alternatives below.
                Prestalia (perindopril / amlodipine)
                Used for:

                • High blood pressure

                $173.26 Lowest GoodRx priceView Prices
                Trandolapril/verapamil
                Used for:

                • High blood pressure

                $129.08 Lowest GoodRx priceView Prices
                Azor (amlodipine / olmesartan)
                Used for:
                $20.58 Lowest GoodRx priceView Prices

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