Prestalia (perindopril / amlodipine) is a combination medication used to treat high blood pressure and helps lower your risk for heart attacks and other heart-related deaths. However, it's much more expensive than other similar medications.
High blood pressure
Prestalia (perindopril / amlodipine) is a combination of two blood pressure medications: perindopril and amlodipine.
Perindopril is an ACE inhibitor. It works by blocking a chemical that normally tightens your blood vessels. This then lowers your blood pressure by allowing your blood vessels to relax.
Amlodipine is a calcium channel blocker (CCB) that also causes your blood vessels to relax and widen, which helps lower your blood pressure.
Source:Â DailyMed
Lowers your risk of heart attack and stroke
Has two effective blood pressure lowering drugs in one pill
Can help protect the kidneys in certain people
Once daily dosing
Might cause more side effects than simliar drugs since it has two medications
Very expensive compared to each drug alone or other similar drugs for blood pressure
Cannot use if pregnant or breastfeeding
Can cause a dry cough
You may feel mild dizziness for the first few days after starting Prestalia (perindopril / amlodipine). This should get better over time as your body adjusts to your lower blood pressure. Tell your healthcare provider if your dizziness doesn't get better after a few days.
If you develop a dry cough after starting Prestalia (perindopril / amlodipine) and it doesn't get any better after one week, let your healthcare provider know. This may be a symptom from Prestalia (perindopril / amlodipine) or a cough from a different condition. If it is from this medication, the cough will go away within a month after you stop it.
If your healthcare provider recommended a low-salt diet, make sure to avoid salt-substitutes and supplements that contain potassium. Combining potassium with Prestalia (perindopril / amlodipine) may cause your blood potassium to reach dangerous levels.
Prestalia (perindopril / amlodipine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Prestalia (perindopril / amlodipine) can cause serious injury or death to an unborn baby. If you are pregnant or think you may be pregnant, stop taking Prestalia (perindopril / amlodipine) right away and talk to your healthcare provider.
Risk factors: Black people | Taking Prestalia (perindopril / amlodipine) with an mTOR inhibitor, like everolimus (Afinitor) or a neprilysin inhibitor, like Entresto (sacubitril/valsartan)
Angioedema (swelling around the eyes, lips, face, throat, hands, or feet) can happen at any time while you're taking Prestalia (perindopril / amlodipine). Tell your healthcare provider right away if you have any of these symptoms.
Risk factors: Taking other medications that lower blood pressure | Dehydration
Prestalia (perindopril / amlodipine) lowers your blood pressure and can make you feel lightheaded or dizzy. These symptoms can be especially severe if you're dehydrated, have a low amount of salt in your body, or are taking other blood pressure medications. Be very mindful of this effect when first starting this medication and for 2 weeks after a dose change.
Risk factors: Current kidney problems | Diabetes | Taking other medications that raise your potassium | Use of certain salt substitutes
Prestalia (perindopril / amlodipine) can raise the amount of potassium in your body. Having high potassium levels can cause issues, including heart problems. Your provider should order routine blood tests to make sure your potassium is within normal range. If you have any signs of muscle weakness, chest pain, irregular heartbeart, or nausea and vomiting, tell your provider right away.
Risk factors: History of kidney problems
In some rare cases, Prestalia (perindopril / amlodipine) can cause kidney failure. You'll need blood tests done to check your kidney function before starting Prestalia (perindopril / amlodipine) and regularly after. Tell your provider if you are not urinating as much as usual or if your urine is dark in color even when you're hydrated.
Although rare, ACE inhibitors like Prestalia (perindopril / amlodipine) can cause liver damage. You'll need blood tests done to check your liver function before starting Prestalia (perindopril / amlodipine) and regularly after. Tell your provider if your skin or eyes turn yellow in color, if you have dark-colored urine, or belly pain and swelling.
The typical starting dose for Prestalia (perindopril / amlodipine) is 3.5 mg/2.5 mg (perindopril/amlodipine) by mouth once daily. If needed, your provider will adjust your dose after a week or two. The maximum dose is 14 mg/10 mg (perindopril/amlodipine) by mouth once daily.
Use of aliskiren with Prestalia (perindopril / amlodipine) in people with diabetes
Use of a neprilysin inhibitor (like Entresto) with Prestalia (perindopril / amlodipine)
Use of Prestalia (perindopril / amlodipine) within 36 hours of using Entresto
High blood pressure
High blood pressure in adults
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