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Podofilox

Podofilox Side Effects

Allison Gourley, PharmDKristianne Hannemann, PharmD
Reviewed by Allison Gourley, PharmD, Kristianne Hannemann, PharmD
Last reviewed on May 2, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Gel:

  • Burning (37%)
  • Inflammation (32%)
  • Itching (32%)
  • Sores (27%)
  • Pain (24%)
  • Bleeding (19%)

Solution:

  • Burning (64% in males, 78% in females)
  • Pain (50% in males, 72% in females)
  • Inflammation (71% in males, 63% in females)
  • Sores (67% in males and females)
  • Itching (50% in males, 65% in females)

Less Common Side Effects

  • Stinging
  • Redness
  • Peeling
  • Scabbing
  • Change in skin color
  • Tenderness
  • Dryness
  • Crusting
  • Cracked skin
  • Soreness
  • Ulcer
  • Swelling or edema (excess fluid under the skin)
  • Rash
  • Blisters
  • Tingling
  • Headache
When do Podofilox possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Burning
Pain
Inflammation
Itching

Source: DailyMed

The following Podofilox side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

More common

Bad odor (solution only)

bleeding of treated skin

blistering, crusting, or scabbing of treated skin

bloody urine (solution only)

burning feeling of treated skin

dizziness (solution only)

headache (gel only)

itching of treated skin

pain during sexual intercourse (solution only)

pain of treated skin

problems with foreskin of penis (solution only)

redness or swelling of treated skin

scarring of treated skin (solution only)

skin ulcers of treated skin

vomiting (solution only)

Symptoms of overdose

in order of occurrence

Nausea

vomiting

diarrhea

chills

fever

sore throat

unusual bleeding or bruising

oral ulcers

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Dryness of treated skin

peeling of treated skin

soreness or tenderness of treated skin

stinging or tingling of treated skin

trouble in sleeping (solution only)

Less common

Changes in color of treated skin (gel only)

skin rash (gel only)

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Allison Gourley, PharmD, is a kidney and pancreas transplant pharmacist at a teaching hospital in the San Francisco Bay Area. When she’s not educating patients about their immunosuppressants, she's actively involved in transplant research.
Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.

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