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Chlorhexidine for Dogs: When to Use This Antiseptic to Treat Skin Infections

Chris Vanderhoof, DVM, MPHGhanasyam Bey, DVM
Written by Chris Vanderhoof, DVM, MPH | Reviewed by Ghanasyam Bey, DVM
Updated on July 2, 2025

Key takeaways:

  • Chlorhexidine is an antiseptic solution used on dogs to kill unwanted bacterial and fungal growth on the skin. This helps treat many types of skin infections.

  • Dogs rarely experience side effects from chlorhexidine. A sensitivity or an allergy that causes redness or irritation on the skin are possible but rare.

  • There are many products containing chlorhexidine for dogs. Always use them as directed.

Chlorhexidine is a disinfectant and antiseptic used on dogs to remove unwanted bacterial or fungal growth from the skin. It can be used for several reasons, from keeping wounds clean to treating skin infections.

Below, we’ll discuss what chlorhexidine is, the types of products it can be found in, how it is used for dogs, and some possible side effects to look out for.

Chlorhexidine for dogs at a glance

Common names

Chlorhexidine

What it treats

Skin infections, hot spots, tick bites, mouth bacteria

How it comes (forms)

Topical solution, shampoo, wipes, mousse, spray, oral rinse

Dosage

2%-4% chlorhexidine for infections, less than 1% chlorhexidine for dental bacteria

Common side effects

Skin irritation, worsening redness or skin irritation

Average cost

$13-$28 for one bottle

What is chlorhexidine for dogs?

Chlorhexidine is a topical antiseptic solution used on a dog’s skin. It works against bacterial and fungal growth that can cause skin infections in dogs. Chlorhexidine gluconate is one of the most common forms.

This medication works by stopping bacteria and fungi from growing on your dog’s skin or in their mouth. As a result, chlorhexidine stops the organisms that lead to infections, helping to protect or treat your pup.

Chlorhexidine may be used alone or with other medications as part of a larger treatment approach. There are also products that combine chlorhexidine with other medications to increase their effectiveness. Chlorhexidine is often combined with miconazole or ketoconazole, for example, to treat fungal infections.

What is chlorhexidine used for on dogs?

There are many times when it may be helpful to use chlorhexidine on your dog. These include the following.

Skin infections

Chlorhexidine can treat skin infections caused by bacteria or fungi. It is especially effective against skin issues caused by the following bacteria:

  • Staphylococcus pseudintermedius

  • Pseudomonas aeruginosa

  • Malassezia

Hot spots

Hot spots occur when your dog repeatedly bites or scratches at the same itchy spot on their skin. This can create a wound that needs treatment to heal effectively. One at-home treatment for hot spots is chlorhexidine, which prevents your dog from developing an infection.

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Tick bite wounds

When you remove a tick from your dog, it’s a good idea to use an antiseptic to clean the wound. Chlorhexidine can treat your dog’s tick wound to help prevent an infection.

Bacteria in the mouth

A chlorhexidine oral rinse for dogs may also help lower bacterial overgrowth in the mouth, a common cause of bad odor and dental disease. These products have a much lower percentage of chlorhexidine, usually less than 1%.

Sterilization before surgery

Chlorhexidine typically appears as a dark-blue solution. This form is most often used in veterinary hospitals to clean and prepare the skin for procedures such as surgery. It’s also used in clinics to clean wounds and infected areas. Chlorhexidine is even used by many veterinarians to clean their own hands before starting a sterile medical procedure.

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What is the dosage of chlorhexidine for dogs, and how is it given?

When included in products, chlorhexidine comes in different concentrations. Most products contain 2% to 4%. At least a 2% concentration is used to treat infections on a dog’s skin. 

Chlorhexidine comes in a number of forms for dogs, including:

Many sprays and wipes are used once or twice a day, especially to treat an infected area. Chlorhexidine shampoos and mousses are used less often, usually a couple of times a week.

You can get many forms of chlorhexidine without a prescription from your veterinarian. Other times, your dog may need a prescription-strength chlorhexidine product. Your dog’s vet will give you instructions on what to buy.

How to give your dog chlorhexidine

How to use chlorhexidine for dogs depends on the product form:

  • Chlorhexidine solution may be sent home by the vet to help clean infected areas on your dog’s skin. Or it may be used as a foot soak for wounds or infections on the feet, toes, and nails.

  • Chlorhexidine wipes are used to clean paws, nail beds, skin hot spots, or other small areas to kill bacteria and fungi. A chlorhexidine spray for dogs may be used in a similar way on smaller areas of concern.

  • Chlorhexidine shampoo for dogs is usually used to reduce bacteria and fungi when multiple areas of the body are affected or when infections affect the hair coat.

  • Chlorhexidine mousse for dogs can be used on larger areas of the skin and the hair coat.

Does chlorhexidine need to be rinsed off?

You don’t need to rinse off most chlorhexidine products. They often work best when they stay in contact with your dog’s skin over time. This is necessary to kill unwanted bacterial or fungal growth.

An exception is chlorhexidine shampoo for dogs, since it has a soapy part. But chlorhexidine shampoo should not be rinsed off right away. It should be left to sit on the

skin for at least 5 to 10 minutes before rinsing.

How often can you use chlorhexidine for dogs?

How often you can use chlorhexidine for dogs depends on what form of product is being used and its purpose. Products that contain chlorhexidine have instructions and guidelines for how often to use them. Your veterinarian will also give you directions on how to use these products.

What are the risks and side effects of chlorhexidine in dogs?

Most dogs tolerate chlorhexidine very well when it is used as directed. But in rare cases, some dogs may develop:

  • Skin irritation

  • Worsening redness or skin irritation

If your dog’s skin irritation or redness worsens, it’s important to tell your veterinarian.

Here are some other tips and precautions for using chlorhexidine on your dog: 

  • Chlorhexidine should not be used in the eyes and must be used very carefully around the eyes and face.

  • Chlorhexidine may be used to clean wounds initially, especially if your dog has an infection. But don’t use chlorhexidine long term on healing wounds, because it can impair and delay healing.

  • Most chlorhexidine solutions and other products for dogs should not be ingested. Chlorhexidine is not especially toxic to dogs, but digestive upset can occur. 

  • To avoid oral or stomach irritation, stop your dog from licking or chewing an area just treated with a chlorhexidine product for at least 20 to 30 minutes.

  • If using for oral and dental health, be sure the chlorhexidine is a low-percentage solution designed for oral use.

  • People can also have a sensitivity to chlorhexidine. If you have a known sensitivity, wear gloves when using chlorhexidine on your dog.

The bottom line

Chlorhexidine is an antiseptic solution widely used to help kill unwanted bacteria and fungal growth on the skin of dogs. Chlorhexidine oral rinse solutions may also be used to lessen bacteria in the mouth.

Chlorhexidine for dogs comes in many forms to help treat conditions at home. It’s safe when used as directed, except in rare cases when a dog may be sensitive to it or allergic. Because there are so many chlorhexidine products for dogs, be sure to follow product instructions and your veterinarian’s recommendations.

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Why trust our experts?

Chris Vanderhoof, DVM, MPH, has been involved with the veterinary field for over 20 years, since working as an assistant at a local veterinary clinic. After earning an associate’s degree in veterinary technology in 2005, Chris transferred to Virginia Tech where he went on to complete his bachelor’s degree, then his doctorate and master’s.
Renée Fabian is the senior pet health editor at GoodRx. She’s worked for nearly 10 years as a journalist and editor across a wide range of health and well-being topics.
Ghanasyam Bey, DVM
Reviewed by:
Ghanasyam Bey, DVM
Ghanasyam Bey, DVM, is from Cleveland, Ohio, and attended Princeton University for undergraduate studies. After a year of biology research at Duke University, he attended Ohio State College of Veterinary Medicine.

References

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.

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