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Perindopril

Perindopril Side Effects

Ally Tsai, PharmDAllison Gourley, PharmD
Reviewed by Ally Tsai, PharmD, Allison Gourley, PharmD
Last reviewed on June 26, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Cough (12%)
  • Dizziness (8%)
  • Back pain (6%)

Perindopril serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Angioedema (severe swelling): swelling of the face, arms, legs, lips, tongue, or throat
  • Dangerously low blood pressure: dizziness, lightheadedness, pale skin, feeling faint
  • Serious kidney problems: urinating less often than usual; swelling in your feet, ankles, or hands; unexplained weight gain
  • High blood potassium levels: nausea, muscle weakness, abnormal heartbeat
  • Serious liver problems: swelling of your stomach, yellowing of your skin or the whites of your eyes, confusion, dark or brown urine
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Source: DailyMed

The following Perindopril side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Body aches or pain

chills

cough

difficulty breathing

ear congestion

fever

headache

loss of voice

nasal congestion

runny nose

sneezing

sore throat

unusual tiredness or weakness

Less common

Bladder pain

bloody or cloudy urine

change in hearing

chest pain

cold

congestion

diarrhea

difficult, burning, or painful urination

dryness of the throat

earache or pain in the ear

ear drainage

frequent urge to urinate

general feeling of discomfort or illness

hoarseness

joint pain

loss of appetite

lower back or side pain

nausea

shivering

stomach pain

swelling

tender, swollen glands in the neck

trouble sleeping

trouble with swallowing

voice changes

vomiting

Rare

Blurred vision

confusion

decreased urination

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

dry mouth

irregular heartbeat

muscle cramps or pain

numbness, tingling, pain, or weakness in the hands or feet

rapid breathing

seizures

sunken eyes

sweating

thirst

trembling

weakness and heaviness of the legs

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Back pain

lack or loss of strength

pain or tenderness around the eyes and cheekbones

tightness of the chest

Less common

Belching

bloated feeling

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

diarrhea

difficulty moving

discouragement

excess air or gas in the stomach or intestines

feeling of fullness

feeling sad or empty

hearing loss

injury

irritability

leg pain

loss of interest or pleasure

muscle ache, stiffness, tension, or tightness

neck pain

nervousness

pain, swelling, or redness in the joints

passing of gas

rash

sleepiness or unusual drowsiness

stomach discomfort or upset

swollen joints

trouble concentrating

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Ally Tsai, PharmD
Reviewed by:
Ally Tsai, PharmD
Ally Tsai, PharmD, is a medication therapy management (MTM) pharmacist with 6 years of experience. As an MTM pharmacist, she helps people with complex medication regimens get the best results by conducting comprehensive medication reviews.
Allison Gourley, PharmD, is a kidney and pancreas transplant pharmacist at a teaching hospital in the San Francisco Bay Area. When she’s not educating patients about their immunosuppressants, she's actively involved in transplant research.

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