oxandrolone
Oxandrolone is an oral tablet belonging to a class called anabolic steroids. It works to help build protein and muscle in adults and children after treatment with long-term steroids. It's also used to relieve osteoporosis-related bone pain. Oxandrolone is a schedule III controlled substance because it carries a risk of misuse, addiction, and dependence. Side effects include acne and swelling from too much fluid.
Note: Oxandrolone is no longer FDA-approved in the United States and therefore isn't available.
What is Oxandrolone?
What is Oxandrolone used for?
Add-on treatment due to protein loss from long-term corticosteroid use
Bone pain from osteoporosis
How Oxandrolone works
Oxandrolone is an anabolic steroid. It's a man-made version of testosterone, a hormone your body makes. By acting like testosterone, oxandrolone helps with weight and muscle growth as well as promote bone strength and health.
Drug Facts
What are the risks and warnings for Oxandrolone?
Oxandrolone can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Liver problems and tumors
Although rare, there have been reports of liver problems caused by blood-filled cysts or sacs (a problem called peliosis hepatis) in people taking anabolic steroids like oxandrolone. It's possible this condition can lead to liver failure or stomach bleeds. Liver tumors have also been seen in people taking this medication.
Depending on how long you're going to be taking oxandrolone, your provider might order blood tests to monitor your liver health regularly during treatment. Tell your provider if you have any signs of liver problems, such as yellowing of the skin, pale stool, and dark urine.
Risk of potential heart problems
Oxandrolone can
raise your "bad" cholesterol (LDL) and lower your "good" cholesterol (HDL). This raises your risk for severe heart problems like coronary artery disease. Your provider might measure your cholesterol levels during treatment with oxandrolone. Make sure to tell your provider if you have a history of high cholesterol or are taking medications for high cholesterol, such as statins or fibrates, before starting oxandrolone.
Swelling in the arms and legs
Risk factors: History of heart, liver, or kidney problems | Taking other medications that cause swelling
Oxandrolone can cause your body to hang on to more fluid, which can cause swelling in the arms and legs. This can be especially serious in people who might be sensitive to changes in water weight, such as those with heart, liver, or kidney problems. Let your provider know if you notice any swelling in your arms and legs or start to gain weight quickly.
Stunted growth in children
Risk factors: Younger age
Children taking oxandrolone might experience stunted growth, where their bones mature faster than they grow, leading to a failure to reach their full growth potential. This causes their adult height to be lower than it would've been had they not taken this medication. The younger the child, the greater the risk. Your child's healthcare provider will check your child's growth progress closely. If they suspect slowed or stunted growth, they might pause or stop your child's oxandrolone treatment.
Prostate problems
Risk factors: Older adults
Older adults using anabolic steroids like oxandrolone are at a higher risk for developing an enlarged prostate (benign prostatic hyperplasia (BPH)) or prostate cancer. Let your provider know if you experience pain in the pelvic area, difficulty urinating, or blood in the urine.
What are the side effects of Oxandrolone?
Common Side Effects
- Acne
- Trouble sleeping
- Swelling of the arms and legs
- Erection problems
- Irritated bladder
- Enlarged clitoris
- Changes to menstrual cycle
- Facial hair growth
- Male pattern baldness
Other Side Effects
- Changes in sex drive
- Depression
- Deepening of the voice
Serious Side Effects
- Liver problems: severe nausea, vomiting, right-sided stomach pain, fatigue, low or no appetite, yellowing of the skin or eyes
Source: DailyMed
The following side effects have also been reported
Tumors of the liver, liver cancer, or peliosis hepatis, a form of liver disease, have occurred during long-term, high-dose therapy with anabolic steroids. Although these effects are rare, they can be very serious and may cause death. Discuss these possible effects with your doctor.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
For both females and males
Less common
Yellow eyes or skin
Rare (with long-term use)
Black, tarry, or light-colored stools
dark-colored urine
purple- or red-colored spots on body or inside the mouth or nose
sore throat and/or fever
vomiting of blood
Check with your doctor as soon as possible if any of the following side effects occur:
For both females and males
Less common
Bone pain
nausea or vomiting
sore tongue
swelling of feet or lower legs
unusual bleeding
unusual weight gain
Rare (with long-term use)
Abdominal or stomach pain
feeling of discomfort (continuing
headache (continuing)
loss of appetite (continuing)
unexplained weight loss
unpleasant breath odor (continuing)
Incidence not known
Lack or slowing of normal bone growth
For females only
For young males (boys) only
Less common
Unexplained darkening of skin
For sexually mature males only
More common
Enlargement of breasts or breast soreness
frequent or continuing erections
frequent urge to urinate
For elderly males only
Less common
>Difficult or frequent urination
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
For both females and males
Less common
Chills
feeling of abdominal or stomach fullness
muscle cramps
trouble in sleeping
unusual decrease or increase in sexual desire
Pros and cons of Oxandrolone
Pros
Dose is personalized for your body's response
Oral tablet taken by mouth
Cons
Risk for misuse, addiction, and dependence
Can cause a serious liver condition that affects different parts of your body
Pharmacist tips for Oxandrolone
Take oxandrolone with or without food.
Mark your appointments in your calendar to see your provider and get any needed blood tests done while taking oxandrolone. Doing this will make sure the medication continues to work for you, and you're not having side effects.
Take oxandrolone exactly as prescribed. Don't change your dose or suddenly stop taking the medication without talking to your provider first.
Let your provider know if you're taking a blood thinner like warfarin (Coumadin) because oxandrolone can raise your risk for bleeding.
Let your provider know if you're taking oral diabetes medications because oxandrolone might prevent them from being broken down in your body, which raises your risk for side effects like low blood sugar.
Since oxandrolone is an anabolic steroid, females might notice changes like more facial hair, acne, or a deeper voice. Let your provider know if you're having any of these symptoms.
Oxandrolone must be avoided in pregnancy due to the potential risk of severe harm to unborn babies. If you're pregnant or thinking of becoming pregnant, talk to your provider.
Frequently asked questions about Oxandrolone
How to save using GoodRx
Oxandrolone dosage forms
Typical dosing for Oxandrolone
Adults: The typical dose is 2.5 mg to 20 mg a day given by mouth, split into 2 to 4 doses throughout the day. The medication is usually taken for 2 to 4 weeks.
Children: The typical dose is up to 0.1 mg/kg of body weight by mouth a day.
Your provider will adjust your dose of the medication based on how well it's helping your condition and if you're having side effects.
Interactions between Oxandrolone and other drugs
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Oxandrolone contraindications
Prostate cancer or male breast cancer
Female breast cancer with high calcium levels
Pregnancy
Nephrosis (a type of kidney disease)
Get savings updates for Oxandrolone
Receive price alerts, news, and other messages from GoodRx about Oxandrolone and other healthcare topics and relevant savings offers.By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx.
References
Best studies we foundGanesan, K., et al. (2023). Anabolic steroids. StatPearls.
Klonteig, S., et al. (2024). Sleep pathology and use of anabolic androgen steroids among male weightlifters in Norway. BioMed Psychiatry.
Mohamad, N. V., et al. (2016). A concise review of testosterone and bone health. Clinical Interventions in Aging.
Par Pharmaceutical, Inc. (2022). Oxandrolone tablet [package insert]. DailyMed.
PubChem. (n.d.). Oxandrolone. National Library of Medicine.
Siddiqi, I. A., et al. (2023). Peliosis hepatis. StatPearls.
Tapia, C., et al. (2023). Nephrotic syndrome. StatPearls.
U.S. Food and Drug Administration. (2023). Gemini Laboratories, LLC, et al.; Withdrawal of approval of one New Drug Application for OXANDRIN (Oxandrolone) tablets and four abbreviated new drug applications for oxandrolone tablets. Federal Register.
You and Your Hormones. (2020). Testosterone.
Zhao, J., et al. (2004). Oxandrolone blocks glucocorticoid signaling in an androgen receptor-dependent manner. Steroids.
Browse medications
View AllResearch prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.