The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Hot flash (24-46%)
- Headache (17-20%)
- Nausea (11-16%)
- Trouble sleeping (6-9%)
- Missing a menstrual period (4-7%)
- Mood swings (5-6%)
- Depressed mood (3-6%)
Less Common Side Effects
- Anxiety
- Joint pain
- Stomach pain
- Diarrhea
- Constipation
- Weight gain
- Dizziness
- Irritability (crankiness)
- Lower sex drive
Orilissa serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious allergic reaction: rash; swelling of your lips, tongue, or throat; trouble breathing
- Liver damage: yellowing of your skin or whites of your eyes, stomach pain, nausea, vomiting, loss of appetite, dark urine, tiredness
- New or worsening depression, anxiety, or other mood or behavior changes
- Suicidal thoughts or behavior
Source: DailyMed
The following Orilissa side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
- Thoughts of suicide or self-harm, worsening mood, feelings of depression
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Anxiety, nervousness
- Headache
- Hot flashes
- Joint pain
- Nausea
- Trouble sleeping
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