The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Diarrhea (13%)
- Dizziness (10%)
- Cough (5%)
- Vomiting (5%)
- Weakness, lack of energy (5%)
- Swelling in your hands and feet (5%)
Less Common Side Effects
- Bladder infection (UTI)
- Flu
- Passing gas
Nuedexta serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Low platelets: lightheaded, fever, chills, nausea, vomiting, skin that bruises easily, purple or red pinpoint spots on skin, bleeding that's difficult to stop, bleeding in your gums or nose, blood in the urine
- Serotonin syndrome: fast heart rate, dizziness, sweating, flushing, tremor (shakiness), muscle stiffness, muscle twitching or spasms, uncoordinated movement, distress, seizures, distress, hallucinations, coma
- Liver damage: severe stomach pain, yellowing of skin or whites of the eyes, nausea, vomiting, loss of appetite
- Abnormal heart rhythm (QT prolongation): chest pounding, short of breath, chest pain, feeling faint or lightheaded
Source: DailyMed
The following Nuedexta side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Less common
Bladder pain
bloating or swelling of the face, arms, hands, lower legs, or feet
bloody or cloudy urine
chills
difficult, burning, or painful urination
frequent urge to urinate
general feeling of discomfort or illness
headache
joint pain
loss of appetite
lower back or side pain
muscle aches and pains
rapid weight gain
shivering
sweating
tingling of the hands or feet
trouble sleeping
unusual tiredness or weakness
unusual weight gain or loss
vomiting
Get emergency help immediately if any of the following symptoms of overdose occur:
Symptoms of overdose
Aggressive and violent behavior
agitation
blurred vision
change in color vision
change in consciousness
chest pain or discomfort
confusion
confusion as to time, place, or person
continuing ringing or buzzing or other unexplained noise in the ears
decreased awareness or responsiveness
difficulty seeing at night
dizziness or lightheadedness
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
double vision
excitement
fainting
fast, pounding, or irregular heartbeat or pulse
feeling of constant movement of self or surroundings
hallucinations
hearing loss
holding false beliefs that cannot be changed by fact
inability to move the eyes
increased blinking or spasms of the eyelid
increased sensitivity of the eyes to sunlight
irregular or slow heart rate
loss of consciousness
overactive reflexes
poor coordination
restlessness
seeing double
seizures
sensation of spinning
severe sleepiness
shakiness and unsteady walk
shivering
shortness of breath
sticking out of tongue
sweating
talking or acting with excitement you cannot control
trembling or shaking
trouble with breathing, speaking, or swallowing
twitching
uncontrolled eye movements
uncontrolled twisting movements of the neck, trunk, arms, or legs
unsteadiness, trembling, or other problems with muscle control or coordination
unusual excitement, nervousness, or restlessness
unusual facial expressions
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

