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Nuedexta

Nuedexta Side Effects

Robert Chad Hakim, PharmD, BCCCPConnie Zheng, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Connie Zheng, PharmD
Last reviewed on January 22, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Diarrhea (13%)
  • Dizziness (10%)
  • Cough (5%)
  • Vomiting (5%)
  • Weakness, lack of energy (5%)
  • Swelling in your hands and feet (5%)

Less Common Side Effects

  • Bladder infection (UTI)
  • Flu
  • Passing gas

Nuedexta serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Low platelets: lightheaded, fever, chills, nausea, vomiting, skin that bruises easily, purple or red pinpoint spots on skin, bleeding that's difficult to stop, bleeding in your gums or nose, blood in the urine
  • Serotonin syndrome: fast heart rate, dizziness, sweating, flushing, tremor (shakiness), muscle stiffness, muscle twitching or spasms, uncoordinated movement, distress, seizures, distress, hallucinations, coma
  • Liver damage: severe stomach pain, yellowing of skin or whites of the eyes, nausea, vomiting, loss of appetite
  • Abnormal heart rhythm (QT prolongation): chest pounding, short of breath, chest pain, feeling faint or lightheaded

Source: DailyMed

The following Nuedexta side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Bladder pain

bloating or swelling of the face, arms, hands, lower legs, or feet

bloody or cloudy urine

chills

cough

diarrhea

difficult, burning, or painful urination

fever

frequent urge to urinate

general feeling of discomfort or illness

headache

joint pain

loss of appetite

lower back or side pain

muscle aches and pains

nausea

rapid weight gain

runny nose

shivering

sore throat

sweating

tingling of the hands or feet

trouble sleeping

unusual tiredness or weakness

unusual weight gain or loss

vomiting

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Aggressive and violent behavior

agitation

blurred vision

change in color vision

change in consciousness

chest pain or discomfort

confusion

confusion as to time, place, or person

continuing ringing or buzzing or other unexplained noise in the ears

decreased awareness or responsiveness

depression

difficulty seeing at night

dizziness or lightheadedness

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

double vision

excitement

fainting

fast, pounding, or irregular heartbeat or pulse

feeling of constant movement of self or surroundings

hallucinations

hearing loss

holding false beliefs that cannot be changed by fact

inability to move the eyes

increased blinking or spasms of the eyelid

increased sensitivity of the eyes to sunlight

irregular or slow heart rate

loss of consciousness

overactive reflexes

poor coordination

restlessness

seeing double

seizures

sensation of spinning

severe sleepiness

shakiness and unsteady walk

shivering

shortness of breath

sticking out of tongue

sweating

talking or acting with excitement you cannot control

trembling or shaking

trouble with breathing, speaking, or swallowing

twitching

uncontrolled eye movements

uncontrolled twisting movements of the neck, trunk, arms, or legs

unsteadiness, trembling, or other problems with muscle control or coordination

unusual excitement, nervousness, or restlessness

unusual facial expressions

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Bloated

excess air or gas in the stomach or intestines

full feeling

lack or loss of strength

passing gas

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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