7 Statin Alternatives You Can Take to Help Lower Your Cholesterol
Statins may not be safe and effective for all people with high cholesterol. Some statin alternatives, like fibrates, may be able to help. Review your options here.
niacin ER
Used for Coronary Artery Disease, High Cholesterol, High Triglycerides
Used for Coronary Artery Disease, High Cholesterol, High Triglycerides
Niacin ER (also known as vitamin B3) is a prescription antilipemic medication for adults. It's used to lower high cholesterol and triglycerides (a common form of fat) levels, but it's not a first-choice option for this condition. Niacin ER is taken by mouth once daily, while niacin (Niacor) is typically taken three times daily. Some side effects of niacin ER include flushing and stomach upset. Please note that niacin is also available over-the-counter to treat vitamin B3 deficiency.
What is Niacin ER?
What is Niacin ER used for?
- High cholesterol and high triglycerides
- Lower risk of repeat heart attack in people with a history of heart attack and high cholesterol
- Slow plaque buildup in the arteries of people with a history of coronary artery disease (CAD) and high cholesterol (as an add-on medication)
- Severely high triglycerides in people who are at risk of pancreatitis (as an add-on medication)
How Niacin ER works
Niacin ER is an antilipemic medication and a naturally occurring vitamin (vitamin B3). It's thought to work by blocking the release of fat from fatty tissue and slow down the production of cholesterol in the liver. It also turns on certain key pathways responsible for removing triglycerides from the body. As a result of these actions, it can help lower "bad" (LDL) cholesterol and triglyceride levels, while raising the "good" (HDL) cholesterol levels.
When does Niacin ER start working?Time passed since treatment started:
Drug facts
| Common Brands | Niacor, Slo-Niacin |
|---|---|
| Drug Class | Antilipemic |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | Lower-cost generic available |
| Availability | Prescription or over-the-counter |
Side effects of Niacin ER
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Flushing (up to 69%)
- Diarrhea (up to 14%)
- Nausea (up to 11%)
Less Common Side Effects
- Vomiting
- Cough
Niacin ER serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Liver damage: severe abdominal pain, yellowing of the skin or whites of your eye, severe nausea, or vomiting
- Muscle pain (rhabdomyolysis): unexplained severe muscle pain, muscle tenderness, or weakness
When do Niacin ER possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Flushing
Risk of liver injury
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.
More on Niacin ER side effects
The following Niacin ER side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Less common
Darkening of urine
light gray-colored stools
loss of appetite
severe stomach pain
yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Abdominal or stomach pain
feeling of warmth
flushing or redness of the skin, especially on the face and neck
headache
nausea or vomiting
rash or itching
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Get your GoodRx coupon
$310.33
GoodRx discount
$30.41
Pros and cons of Niacin ER
Pros
- Can lower “bad” (LDL) cholesterol and raise “good” (HDL) cholesterol in people who have trouble doing so with diet and exercise alone
- Can also lower triglycerides
- An option for people who didn’t have success or had side effects with statins
- Available as a lower-cost generic medication
Cons
- Doesn’t work as well as statin medications in lowering cholesterol and triglycerides
- Can cause flushing, a bothersome side effect
- Need to take immediate-release form multiple times a day
- Not recommended during pregnancy or breastfeeding
Pharmacist tips for Niacin ER
- If you're taking the immediate-release form of niacin, start by taking the medication after your evening meal. If you’re taking the extended-release form of niacin, take the medication at bedtime after you eat a low-fat snack such as fruit, pretzels, or carrots. This lowers your risk of side effects like flushing and stomach upset.
- Swallow the extended-release tablets whole. Don't crush or chew them as too much medication might get released at once, which can cause side effects.
- Don't drink alcohol, hot beverages, or eat spicy food right before you take this medication as it might raise the chance of flushing and itching of the skin.
- Niacin ER might make your skin feel hot and turn red (flushing). Typically, people get used to the medication and flushing can go away after several weeks. If you’re taking the immediate-release form of niacin, your healthcare provider might recommend that you take an aspirin or non-steroidal anti-inflammatory drug (NSAID) before you take niacin ER to lower your risk of flushing.
- Niacin ER might affect your blood sugar levels. If you have a history of diabetes or high blood sugar levels, your healthcare provider might have you monitor your blood sugar levels at home more often. Be sure to tell your provider if you notice any changes in your sugar levels.
- Niacin ER can raise uric acid levels, which can worsen your gout. Talk to your healthcare provider if you're having more gout attacks.
Risks and warnings for Niacin ER
Niacin ER can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Muscle breakdown that can lead to kidney and heart damage (rhabdomyolysis)
- Risk factors: Taking niacin ER with statins | Age 65 years or older | History of diabetes, kidney problems, or low thyroid levels
Although rare, taking niacin ER together with a statin medication can cause a serious condition called rhabdomyolysis. This is when damaged muscle tissue is broken down in your body and releases proteins into the bloodstream, which can cause very serious and sometimes deadly kidney and heart damage. Talk to your healthcare provider if you develop sudden unexplained muscle pain, weakness, and tenderness, especially after you first start taking niacin ER or after your dose is raised.
Liver damage
- Risk factors: Heavy alcohol use | Past or current liver disease | Using sustained-release niacin ER in place of the immediate-release form at equal doses
Niacin ER can cause serious and life-threatening liver damage, especially if you switch from the immediate-release form of niacin ER to the sustained-release form at equal doses. These forms are not the same and you should not switch between them, even at equivalent doses. This can cause you to take a much higher dose than recommended and raise your risk of liver damage. Additionally, if you're a heavy drinker of alcohol or have a history of liver problems you might be at higher risk for liver damage. Don't take niacin ER if you have active liver disease. Your healthcare provider will monitor your liver by doing blood tests while you're taking niacin ER. If you start to notice severe abdominal pain, nausea or vomiting, or yellowing of the skin or whites of the eye, contact your healthcare provider right away.
Niacin ER dosage
The average cost for 90 tablets of 500mg of Niacin ER is $30.41 with a free GoodRx coupon. This is 90.20% off the average retail price of $310.33. 
Tablet
Tablet| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 500mg | 90 tablets | $30.41 | $0.34 |
| 750mg | 90 tablets | $45.57 | $0.51 |
| 1000mg | 90 tablets | $37.75 | $0.42 |
Typical dosage for Niacin ER
Only prescription-strength niacin ER is FDA-approved to treat high cholesterol levels. Also, immediate-release and extended-release forms of niacin aren't the same and can't be substituted, one for the other.
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Niacin immediate-release tablets: The typical starting dose is 250 mg by mouth once a day with dinner. Your provider might raise your dose every few days or weeks until you reach your target cholesterol levels. The typical maintenance dose is 1,000 mg to 2,000 mg two to three times a day. Don't take more than 6,000 mg of niacin immediate-release a day.
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Niacin extended-release tablets: The typical starting dose is 500 mg by mouth at bedtime, after a low-fat snack. After 4 weeks, your provider will raise your dose depending on how you’ve tolerated and responded to the medication. The typical maintenance dose is 1,000 mg to 2,000 mg daily at bedtime. The maximum recommended dose is 2,000 mg daily.
Interactions between Niacin ER and other drugs
Niacin ER may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Niacin ER. Please note that only the generic name of each medication is listed below.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
How much does Niacin ER cost?
To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Niacin ER (generic)
$30.41
Niacin ER contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Niacin ER will not be safe for you to take.
- Active liver disease
- Active peptic ulcer disease
- Unexplained high liver enzymes
- Arterial bleeding
What are alternatives to Niacin ER?
There are a number of medications that your doctor can prescribe in place of Niacin ER. Compare a few possible alternatives below.
News about Niacin ER
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