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Nefazodone

Nefazodone Side Effects

Shifali Patel, PharmDKristianne Hannemann, PharmD
Reviewed by Shifali Patel, PharmD, Kristianne Hannemann, PharmD
Last reviewed on May 17, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Headache (36%)
  • Sleepiness (25%)
  • Dry mouth (25%)
  • Nausea (22%)
  • Dizziness (17%)
  • Constipation (14%)
  • Trouble sleeping (11%)
  • Weakness (11%)
  • Lightheadedness (10%)
  • Blurred vision (9%)
  • Indigestion (9%)

Less Common Side Effects

  • Diarrhea
  • Infection
  • Confusion
  • Vision changes
  • Sore throat
  • Larger appetite
  • Memory problems
  • Low blood pressure upon standing
  • Feeling flushed or warm
  • Burning, tingling, or numbing feeling in arms or legs

Nefazodone serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Severe allergic reaction: itchy red rash (hives), shortness of breath, chest tightness, swelling of lips, tongue, face, or eyes
  • Liver problems: yellowing of the skin or eyes (jaundice), stomach pain or swelling, loss of appetite, dark urine, nausea, vomiting, tiredness or weakness, confusion
  • Seizures: uncontrolled jerking movements of arms or legs, stiff body, staring, trouble breathing, confusion, unconsciousness
  • Suicidal thinking and behavior

Source: DailyMed

The following Nefazodone side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

More common

Blurred vision or other changes in vision

clumsiness or unsteadiness

lightheadedness or fainting

ringing in the ears

skin rash or itching

Less common

Bladder pain

bloody or cloudy

cough or hoarseness

diarrhea

excessive muscle tone

eye pain

feeling dizzy

frequent urge to urinate

itching of the vagina or genital area

muscle stiffness

muscle tension or tightness

nausea

pain during sexual intercourse

painful, burning, or difficult urination

shortness of breath, tightness in chest, or wheezing

stomach pain

thick, white vaginal discharge with no odor or with a mild odor

troubled breathing

Rare

Asthma

bleeding from the rectum

bloody or black, tarry stools

change in sexual desire or performance

chest pain

double vision

dryness of eye

ear pain

fainting

fast heartbeat

fever, chills, or sore throat

hallucinations (seeing, hearing, or feeling things that are not there)

hives

increased sense of hearing

increased sensitivity to sun

irritation or soreness of mouth

joint or muscle pain or stiffness

kidney stones

large pupils of eyes

lower back, side, or stomach pain

menstrual changes

mood or mental changes

nerve pain or twitching

pelvic pain

problems in speaking

problems with urination

prolonged, painful, inappropriate penile erection

red or irritated eyes

sensitivity of eyes to light

swelling of face

swollen glands

talking, feeling, and acting with excitement and activity you cannot control

unusual bleeding or bruising

unusual feeling of well-being

unusual tiredness or weakness

vomiting of blood or material that looks like coffee grounds

Incidence not known

Blistering, peeling, or loosening of skin

light-colored stools

confusion

dark urine

decreased urine output

fever

increased thirst

itching

lack of appetite

large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

muscle pain or cramps

muscle spasm or jerking of all extremities

muscle stiffness

pain, warmth, or burning in fingers, toes, and legs

red skin lesions, often with a purple center

sore throat

sudden loss of consciousness

sweating

vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Abnormal dreams

agitation

confusion

constipation

diarrhea

dizziness

drowsiness

dryness of mouth

flushing or feeling of warmth

headache

heartburn

increased appetite

increased cough

memory problems

nausea

swelling of arms or legs

tingling, burning, or prickly sensations

tremor

trouble in sleeping

vomiting

Less common or rare

Breast pain

generalized slowing of mental and physical activity

increased thirst

loss of strength or energy

muscle weakness

Incidence not known

Unexpected or excess milk flow from breasts

swelling of the breasts or breast soreness in males

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Shifali Patel, PharmD, worked as a pharmacist in a hospital setting for 3 years prior to joining GoodRx. As a hospital pharmacist, she reviewed medication orders for safety and accuracy, optimized medication therapy, provided clinical information to healthcare providers, and educated people about their medications.
Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.

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