The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Headache (26%)
- Dry mouth (17%)
- Nausea (13%)
- Trouble sleeping (11%)
- Constipation (10%)
- Dizziness (7%)
Less Common Side Effects
- Diarrhea
- Stomach pain
- Low appetite
- Anxiety
- Tremor (shaking)
- Nervousness
- Fast heartbeat
- Sweating
- Ringing in the ears
- Muscle pain
- Rash
- Sore throat
- Infection
Note: Side effects are reported from people taking bupropion (Wellbutrin) for depression at the target dose.
Aplenzin serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Suicidal thoughts or behaviors
- Serious allergic reaction or skin reaction: sore throat, fever, fatigue, rash, hives, painful blisters, skin reddening, skin peeling, swollen lymph nodes, swelling of the face, trouble breathing
- Seizures
Source: DailyMed
More on Aplenzin side effects

The following Aplenzin side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
hyperventilation
irregular heartbeats
irritability
restlessness
shaking
trouble sleeping
Rare
Confusion
fainting
false beliefs that cannot be changed by facts
having extreme distrust of people
seeing, hearing, or feeling things that are not there
seizures
trouble concentrating
Incidence not known
Actions that are out of control
anger
assaulting or attacking others
being aggressive or impulsive
chest pain or discomfort
fast or pounding heartbeat
force
inability to sit still
need to keep moving
sweating
talking, feeling, or acting with excitement
Get emergency help immediately if any of the following symptoms of overdose occur:
Symptoms of overdose
Lightheadedness, dizziness, or fainting
loss of consciousness
slow or irregular heartbeat
unusual tiredness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Blurred vision
change in sense of taste
drowsiness
unusual feeling of well-being
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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