Naftifine cream is a topical antifungal medication that's used to treat athlete's foot, jock itch, and ringworm. The 1% and 2% strengths are approved for adults. Depending on the type of fungal infection, children of certain ages can also use the 2% strength of the cream. This medication is applied directly onto the affected areas of skin once per day for up to a few weeks. Side effects aren't common but can include itchiness, burning or stinging on the skin, and dry skin.
Jock itch - 1% and 2% strengths
Ringworm - 1% and 2% strengths
Athlete's foot - 1% strength only
Athlete's foot between the toes - 2% strength only
Naftifine cream is an allylamine antifungal. It isn't clear how the medication exactly works. But it's thought to work by blocking the fungus causing the infection from making important proteins needed for survival.
Source:Â DailyMed
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Less common
Burning, stinging, itching, redness, or irritation of the skin
Incidence not known
Blistering or crusting of the skin
softening of the skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Dizziness
headache
Less common
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Can treat a few different fungal skin infections (athlete's foot, jock itch, or ringworm)
Applied once per day
Has few side effects
Available by prescription only
Need to use for 2 to 4 weeks
Can cause mild skin irritation
Use the naftifine cream for the full amount of time that your prescriber recommended (up to 4 weeks for the 1% strength or 2 weeks for the 2% strength). Don't stop using it early, even if your symptoms get better. Stopping treatment too soon can raise the risk that the skin infection can come back.
Apply a thin layer of the naftifine cream to the affected areas on your skin. For treating athlete's foot with the 2% strength of the cream, also apply the medication to the skin in between the toes.
Make sure to wash your hands with soap and water before you use the naftifine cream. This prevents more germs from getting into the infected areas of skin.
Also wash your hands with soap and water after you've applied the naftifine cream, unless you're treating your hands. This lowers the chance that you accidentally get medication in your eyes or other sensitive areas of the body. If the medication gets in your eyes, rinse them well with water.
Don't put any naftifine cream in the eyes, mouth, or vagina because it can cause burning and irritation. Be careful if you're applying the medication to the skin around or near those areas. If you accidentally get the naftifine cream in those spots, wash it well with water.
Some people can have skin reactions, such as burning, stinging, itching, or irritation, after they apply the naftifine cream. Contact your prescriber if these side effects get worse over time or if you see any blistering, swelling, or oozing. These might be signs of a different, more serious skin condition.
Don't cover the areas where you apply the naftifine cream with tight bandages or dressings unless your prescriber tells you to. Usually, you want the area to "breathe" and stay dry so it can heal.
If you're pregnant or breastfeeding, talk to a healthcare professional about treatment options for fungal skin infections. There isn't enough information about whether the naftifine cream is safe to use on the skin while pregnant or breastfeeding.
Store the naftifine cream at room temperature in a cool and dry spot away from pets and children. Contact your local Poison Center right away at 1-800-222-1222 if a child or animal swallows any of the medication.
Naftifine cream can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Only apply naftifine cream to the surface of your skin. Don't put the medication into the eyes, nose, or vagina. Applying naftifine cream to these sensitive areas can cause pain and irritation. Let your prescriber know if your skin becomes very irritated or sensitive as you use this medication. You might have to switch to a different medication.
Age 18 years and older: Apply a thin layer to the affected area(s) once per day for up to 4 weeks. Also apply a thin layer of medication to the surrounding areas of the affected skin.
Age 12 years and older (for jock itch or athlete's foot between the toes): Apply a thin layer to the affected area(s) once per day for 2 weeks. Be sure to also apply the medication to about a half-inch of healthy skin surrounding the affected area(s).
Age 2 years and older (for ringworm): Apply a thin layer to the areas of ringworm once per day for 2 weeks. Also apply the cream to about a half-inch of skin just surrounding the areas of ringworm.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Jock itch - 1% and 2% strengths
Ringworm - 1% and 2% strengths
Athlete's foot - 1% strength only
Athlete's foot between the toes - 2% strength only
Jock itch
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Å veikauskaitÄ—, I., et al. (2020). Potential of naftifine application for transungual delivery. Molecules.
Taro Pharmaceuticals U.S.A., Inc. (2018). Naftifine hydrochloride cream [package insert]. DailyMed.
Xiromed, LLC. (2021). Naftifine hydrochloride cream [package insert]. DailyMed.
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