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Minizide

prazosin and polythiazide
Used for Hypertension

Minizide (prazosin / polythiazide) is a combination medication used to treat high blood pressure. It has been discontinued and is no longer available in the United States.

Reviewed by:
reviewerSarah Lobello Pearson, PharmD
reviewerKristianne Hannemann, PharmD
Last reviewed on June 2, 2022
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What is Minizide (prazosin / polythiazide)?

What is Minizide (prazosin / polythiazide) used for?

  • High blood pressure (hypertension)

Drug facts

Common BrandsMinizide(brand no longer available)
Drug ClassAlpha blocker / Diuretic (water pill)
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityDiscontinued
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Common questions about Minizide (prazosin / polythiazide)

Minizide (prazosin / polythiazide) is a medication taken by mouth that's used to lower blood pressure. It's a combination of two medications, prazosin and polythiazide. Prazosin is an alpha blocker, which lowers blood pressure by relaxing blood vessels. Polythiazide is a diuretic (water pill), which lowers blood pressure by lowering the amount of fluid buildup in your body.

No, Minizide (prazosin / polythiazide) has been discontinued and is no longer available in the United States.

It's not clear why Minizide (prazosin / polythiazide) was discontinued. Prazosin is still available as a single-ingredient medication (also known as the brand Minipress), which can be used to treat high blood pressure. Polythiazide was available as a single-ingredient medication at one time. But, it has also been discontinued and is no longer available in the United States.

There are many medications available that can treat high blood pressure. Prazosin (Minipress) alone is available and can be used to treat high blood pressure, among other conditions. And there are diuretics that are similar to polythiazide (e.g., hydrochlorothiazide (Microzide), chlorothiazide (Diuril)) that can also be used for high blood pressure. In addition, there are other combination products that include two different types of blood pressure medications. Some examples include Zestoretic (lisinopril / hydrochlorothiazide) and Diovan HCT (valsartan / hydrochlorothiazide). These medications might not be appropriate for everyone. Talk to your provider about what the best treatment choice is for you.

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Minizide (prazosin / polythiazide) dosage

Typical dosage for Minizide (prazosin / polythiazide)

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What are alternatives to Minizide (prazosin / polythiazide)?

There are a number of medications that your doctor can prescribe in place of Minizide (prazosin / polythiazide). Compare a few possible alternatives below.
Minizide (prazosin / polythiazide)
Used for:
  • High blood pressure (hypertension)
View prices
Used for:
$12.18Lowest GoodRx priceView prices
Used for:
$4.00Lowest GoodRx priceView prices

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