Is Minizide (prazosin / polythiazide) still available?

No, Minizide (prazosin / polythiazide) has been [discontinued](https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=017986) and is no longer available in the United States.

Minizide

Q: What is Minizide (prazosin / polythiazide)?

Minizide (prazosin / polythiazide) is a medication taken by mouth that's used to lower blood pressure. It's a combination of two medications, prazosin and polythiazide. Prazosin is an alpha blocker, which lowers blood pressure by relaxing blood vessels. [Polythiazide](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=abd6ecf0-dc8e-41de-89f2-1e36ed9d6535) is a diuretic (water pill), which lowers blood pressure by lowering the amount of fluid buildup in your body.

Q: Why was Minizide (prazosin / polythiazide) discontinued?

It's not clear why Minizide (prazosin / polythiazide) was discontinued. Prazosin is still available as a single-ingredient medication (also known as the brand [Minipress](https://www.goodrx.com/prazosin/what-is)), which can be used to treat high blood pressure. Polythiazide was available as a single-ingredient medication at one time. But, it has also been [discontinued](https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=012845) and is no longer available in the United States.

prazosin and polythiazide

Used for Hypertension

Minizide (prazosin / polythiazide) is a combination medication used to treat high blood pressure. It has been discontinued and is no longer available in the United States.

Reviewed by:

Sarah Lobello Pearson, PharmD

Kristianne Hannemann, PharmD

Last reviewed on June 2, 2022

What is Minizide (prazosin / polythiazide)?

What is Minizide (prazosin / polythiazide) used for?

High blood pressure (hypertension)

Are you looking for information on prazosin (Minipress) instead?

Drug facts

Common Brands	Minizide(brand no longer available)
Drug Class	Alpha blocker / Diuretic (water pill)
Controlled Substance Classification	Not a controlled medication
Generic Status	No lower-cost generic available
Availability	Discontinued

Common Brands

Minizide(brand no longer available)

Drug Class

Alpha blocker / Diuretic (water pill)

Controlled Substance Classification

Not a controlled medication

Generic Status

No lower-cost generic available

Availability

Discontinued

Common questions about Minizide

Minizide is a medication taken by mouth that's used to lower blood pressure. It's a combination of two medications, prazosin and polythiazide. Prazosin is an alpha blocker, which lowers blood pressure by relaxing blood vessels. Polythiazide is a diuretic (water pill), which lowers blood pressure by lowering the amount of fluid buildup in your body.

No, Minizide has been discontinued and is no longer available in the United States.

It's not clear why Minizide was discontinued. Prazosin is still available as a single-ingredient medication (also known as the brand Minipress), which can be used to treat high blood pressure. Polythiazide was available as a single-ingredient medication at one time. But, it has also been discontinued and is no longer available in the United States.

There are many medications available that can treat high blood pressure. Prazosin (Minipress) alone is available and can be used to treat high blood pressure, among other conditions. And there are diuretics that are similar to polythiazide (e.g., hydrochlorothiazide (Microzide), chlorothiazide (Diuril)) that can also be used for high blood pressure. In addition, there are other combination products that include two different types of blood pressure medications. Some examples include Zestoretic (lisinopril / hydrochlorothiazide) and Diovan HCT (valsartan / hydrochlorothiazide). These medications might not be appropriate for everyone. Talk to your provider about what the best treatment choice is for you.

Minizide (prazosin / polythiazide) dosage

Typical dosage for Minizide (prazosin / polythiazide)

What are alternatives to Minizide (prazosin / polythiazide)?

There are a number of medications that your doctor can prescribe in place of Minizide (prazosin / polythiazide). Compare a few possible alternatives below.

Minizide (prazosin / polythiazide)

Used for:

High blood pressure (hypertension)

View prices

Prazosin (Minipress)

Used for:

High blood pressure (hypertension)

$9.02Lowest GoodRx priceView prices

Hydrochlorothiazide

Used for:

High blood pressure
Swelling in the body from fluid buildup (edema)

$4.00Lowest GoodRx priceView prices

What is Minizide (prazosin / polythiazide)?

What is Minizide (prazosin / polythiazide) used for?

Are you looking for information on prazosin (Minipress) instead?

Drug facts

Common questions about Minizide

What is Minizide?

Is Minizide still available?

Why was Minizide discontinued?

What alternatives can I use instead of Minizide?

Minizide (prazosin / polythiazide) dosage

Typical dosage for Minizide (prazosin / polythiazide)

What are alternatives to Minizide (prazosin / polythiazide)?

Common questions about Minizide

What is Minizide?

Is Minizide still available?

Why was Minizide discontinued?

What alternatives can I use instead of Minizide?