Miglustat (Zavesca) is an oral medication used to treat adults with mild to moderate type 1 Gaucher disease. It’s only used in people who can’t receive enzyme replacement therapy (ERT). Miglustat (Zavesca) is available as a generic medication so it might be less expensive than other branded medications approved for this condition.
Mild to moderate type 1 Gaucher disease in adults
Miglustat (Zavesca) is a glucosylceramide synthase inhibitor. People with Gaucher disease don't have enough of an enzyme, a specific protein, that breaks down fatty substances (glycosphingolipids) called glucosylceramides. As a result, there are higher levels of glucosylceramide in the body, and it can build up in the spleen, liver, and bones. Miglustat (Zavesca) helps to lower the amount of glucosylceramide in your body by blocking it from being made.
Source: DailyMed
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Black, tarry stools
bleeding gums
blood in the urine or stools
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
pinpoint red spots on the skin
trembling or shaking in the hands
unsteadiness or awkwardness
unusual bleeding or bruising
weakness in the arms, hands, legs, or feet
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Back pain
bloated or full feeling
blurred or loss of vision
difficulty having a bowel movement (stool)
disturbed color perception
dizziness
double vision
excess air or gas in the stomach or intestines
halos around lights
headache
heaviness in the limbs
indigestion
leg cramps
loss of appetite
memory loss
menstrual changes
pain or discomfort in the chest, upper stomach, or throat
passing gas
stomach discomfort, upset or pain
swelling of the abdominal or stomach area
tunnel vision
unsteady walk
vomiting
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Available as a lower-cost generic medication
More convenient than frequent trips to the infusion center for ERT
Is available as an oral medication, so it doesn’t require an IV or port compared to ERT
Doesn't require genetic testing before starting like Cerdelga (eliglustat)
Diarrhea and tremors are very common side effects
Is taken three times a day in most adults
Not for use in children or teenagers with type 1 Gaucher disease
Can only be used if you can’t receive ERT
Take miglustat (Zavesca) by mouth three times a day, or about every 8 hours. It can be taken with or without food. Spacing miglustat (Zavesca) from meals can help with diarrhea, but the opposite effect has also been seen in some people.
Try to take miglustat (Zavesca) around the same times every day. If you miss a dose, skip it and take your next scheduled dose at your usual time.
Miglustat (Zavesca) can cause new or worsening tremors, usually in the hands. Let your provider know if you have bothersome tremors or tremors that don't improve within a few months after starting this medication. In some cases, your provider might need to lower your dose, or you might have to stop taking miglustat (Zavesca) altogether.
Diarrhea is a very common side effect of miglustat (Zavesca). Luckily, it can be improved by changes in your diet. It's recommended to eat fewer foods that contain sugar, dairy, and carbohydrates while taking miglustat (Zavesca). Diarrhea should also improve over time. Let your provider know if you have worsening or bothersome diarrhea.
Miglustat (Zavesca) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Miglustat (Zavesca) can cause nerve problems, or peripheral neuropathy. This can affect your arms, hands, legs, and feet. Your provider will perform a neurologic exam before you start this medication, and about twice a year during treatment. Let your provider know if you experience numbness, burning, a feeling of "pins and needles", tremors, problems with balance, or weakness in your arms or legs. You might need to stop taking miglustat (Zavesca) depending on your symptoms.
Risk factors: History of tremor
Miglustat (Zavesca) can commonly cause new or worsening tremors, typically in the hands. This usually begins within the first month of treatment and goes away after a few more months of taking this medication. Depending on your symptoms, your provider might need to lower your dose or have you stop taking miglustat (Zavesca) altogether.
Miglustat (Zavesca) commonly causes diarrhea and weight loss. Miglustat (Zavesca) affects the way your intestines absorb sugars from your diet. When not enough sugars are absorbed, more water is drawn into the intestines and causes diarrhea. The diarrhea improves over time while taking this medication. Changing your diet (eating fewer foods that contain sugar, dairy, or carbohydrates), taking miglustat (Zavesca) in between meals, or taking anti-diarrheal medications like loperamide (Imodium A-D) can also help prevent diarrhea. Let your provider know if you continue to have diarrhea that doesn't improve with time or changes in your diet.
You might start losing weight while taking miglustat (Zavesca), especially during the first year of treatment. It's unclear whether this weight loss is due to the diarrhea or other stomach issues, eating less food, or a combination of these factors.
Risk factors: History of low platelet counts
Miglustat (Zavesca) can lower your platelet counts. This is generally mild and doesn’t usually result in bleeding. Your provider will regularly check your blood counts to monitor your platelets.
The typical dose is 100 mg by mouth three times daily, or about every 8 hours. Your dose might differ if you have kidney problems.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Type 1 Gaucher disease in adults and children 2 years of age or older
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